The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound
Site-specific delivery of chemotherapeutics using actively targeted-stimuli-responsive liposomes is a promising approach to enhance the therapeutic efficiency of anti-cancer drugs while reducing the associated undesirable side effects. Recently, the co-functionalization of liposomes has shown intere...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
2022
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/24777 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513443344678912 |
|---|---|
| author | AlSawaftah, Nour Majdi |
| author2 | Husseini, Ghaleb Pitt, William G. |
| author2_role | author author |
| author_facet | AlSawaftah, Nour Majdi Husseini, Ghaleb Pitt, William G. |
| author_role | author |
| dc.creator.none.fl_str_mv | AlSawaftah, Nour Majdi Husseini, Ghaleb Pitt, William G. |
| dc.date.none.fl_str_mv | 2022-10-10T07:05:34Z 2022-10-10T07:05:34Z 2022 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | AlSawaftah, N.; Husseini, G.; Pitt, W.; The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound. Journal of Biomedical Nanotechnology, 2022, Vol. 18, 1–12. https://doi.org/10.1166/jbn.2022.3392. 1550-7041 http://hdl.handle.net/11073/24777 10.1166/jbn.2022.3392 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | American Scientific Publishers |
| dc.relation.none.fl_str_mv | https://doi.org/10.1166/jbn.2022.3392 |
| dc.subject.none.fl_str_mv | Ultrasound Drug Release Targeted Nanocarriers Herceptin Estrone |
| dc.title.none.fl_str_mv | The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound |
| dc.type.none.fl_str_mv | Peer-Reviewed Postprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Site-specific delivery of chemotherapeutics using actively targeted-stimuli-responsive liposomes is a promising approach to enhance the therapeutic efficiency of anti-cancer drugs while reducing the associated undesirable side effects. Recently, the co-functionalization of liposomes has shown interesting results in enhancing cellular uptake; however, such systems suffer from stability issues. This study proposes mixing calcein-loaded liposomes decorated with different ligands, namely estrone and Herceptin, to treat breast cancer. We investigated the low-frequency ultrasound-mediated release of calcein from the synthesized liposomes (control, estrone-modified, Herceptin-modified, and mixed estrone and Herceptin liposomes at different volume fractions). The results showed that the release increased as the power density increased and that estrone-conjugated liposomes achieved the highest release under all test conditions. |
| format | article |
| id | aus_dc1f984c1dc7144218d46d68d36c4724 |
| identifier_str_mv | AlSawaftah, N.; Husseini, G.; Pitt, W.; The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound. Journal of Biomedical Nanotechnology, 2022, Vol. 18, 1–12. https://doi.org/10.1166/jbn.2022.3392. 1550-7041 10.1166/jbn.2022.3392 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/24777 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | American Scientific Publishers |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | The Kinetics of Calcein Release from Mixed Targeted Liposomes Using UltrasoundAlSawaftah, Nour MajdiHusseini, GhalebPitt, William G.UltrasoundDrug ReleaseTargeted NanocarriersHerceptinEstroneSite-specific delivery of chemotherapeutics using actively targeted-stimuli-responsive liposomes is a promising approach to enhance the therapeutic efficiency of anti-cancer drugs while reducing the associated undesirable side effects. Recently, the co-functionalization of liposomes has shown interesting results in enhancing cellular uptake; however, such systems suffer from stability issues. This study proposes mixing calcein-loaded liposomes decorated with different ligands, namely estrone and Herceptin, to treat breast cancer. We investigated the low-frequency ultrasound-mediated release of calcein from the synthesized liposomes (control, estrone-modified, Herceptin-modified, and mixed estrone and Herceptin liposomes at different volume fractions). The results showed that the release increased as the power density increased and that estrone-conjugated liposomes achieved the highest release under all test conditions.American University of SharjahAlJalila FoundationAl Qasimi FoundationPatient’s Friends CommitteeBiosciences and Bioengineering Research InstituteGCC Co-Fund ProgramTakamulTechnology Innovation Pioneer-Healthcare (TIP) ProgramSheikh Hamdan Award for Medical SciencesFriends of Cancer Patients (FoCP)Dana Gas Endowed Chair for Chemical EngineeringAmerican Scientific Publishers2022-10-10T07:05:34Z2022-10-10T07:05:34Z2022Peer-ReviewedPostprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAlSawaftah, N.; Husseini, G.; Pitt, W.; The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound. Journal of Biomedical Nanotechnology, 2022, Vol. 18, 1–12. https://doi.org/10.1166/jbn.2022.3392.1550-7041http://hdl.handle.net/11073/2477710.1166/jbn.2022.3392en_UShttps://doi.org/10.1166/jbn.2022.3392oai:repository.aus.edu:11073/247772024-08-22T12:05:50Z |
| spellingShingle | The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound AlSawaftah, Nour Majdi Ultrasound Drug Release Targeted Nanocarriers Herceptin Estrone |
| status_str | publishedVersion |
| title | The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound |
| title_full | The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound |
| title_fullStr | The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound |
| title_full_unstemmed | The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound |
| title_short | The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound |
| title_sort | The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound |
| topic | Ultrasound Drug Release Targeted Nanocarriers Herceptin Estrone |
| url | http://hdl.handle.net/11073/24777 |