Harnessing piperine for enhanced antimicrobial activity of carbon dot‑modified cellulose fibers
Microbial infections are a global health challenge often treated with antibiotics, but their overuse can lead to antibiotic resistance. To address this, there is a need for more efficient personal protective equipment (PPE) with novel antimicrobial techniques. One such technique involves using carbo...
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2024
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| Online Access: | https://hdl.handle.net/11073/25583 |
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| _version_ | 1864513438877745152 |
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| author | Ravindran, Sreeshna |
| author2 | Khan, Danyah Khodja, Abdelhamid Terro, Tala Radha, Remya Diab, Rasha Ialyshev, Vadim Al‑Sayah, Mohammad H. |
| author2_role | author author author author author author author |
| author_facet | Ravindran, Sreeshna Khan, Danyah Khodja, Abdelhamid Terro, Tala Radha, Remya Diab, Rasha Ialyshev, Vadim Al‑Sayah, Mohammad H. |
| author_role | author |
| dc.creator.none.fl_str_mv | Ravindran, Sreeshna Khan, Danyah Khodja, Abdelhamid Terro, Tala Radha, Remya Diab, Rasha Ialyshev, Vadim Al‑Sayah, Mohammad H. |
| dc.date.none.fl_str_mv | 2024-09-16T07:01:34Z 2024-09-16T07:01:34Z 2024 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Ravindran, S., Khan, D., Khodja, A. et al. Harnessing piperine for enhanced antimicrobial activity of carbon dot-modified cellulose fibers. Discov Appl Sci 6, 490 (2024). https://doi.org/10.1007/s42452-024-06187-4 3004-9261 https://hdl.handle.net/11073/25583 10.1007/s42452-024-06187-4 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Springer |
| dc.relation.none.fl_str_mv | https://doi.org/10.1007/s42452-024-06187-4 |
| dc.subject.none.fl_str_mv | Carbon dots Cellulose Piperine Boronic acid Antimicrobial fibers Staphylococcus epidermidis Escherichia coli Serratia marcescens MTT Cell viability Self-disinfecting fabrics |
| dc.title.none.fl_str_mv | Harnessing piperine for enhanced antimicrobial activity of carbon dot‑modified cellulose fibers |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Microbial infections are a global health challenge often treated with antibiotics, but their overuse can lead to antibiotic resistance. To address this, there is a need for more efficient personal protective equipment (PPE) with novel antimicrobial techniques. One such technique involves using carbon dots (CDs) to create self-disinfecting fabrics. This study focused on synthesizing phenylboronic-acid-functionalized piperine-based carbon dots (PBA-PPCDs) and boronic acid carbon dots (BACDs) as potential antimicrobial agents. The materials were successfully synthesized using a hydrothermal method and characterized using various techniques to confirm the size, charge, fluorescence properties, and inner morphology of the CDs. The CDs showed bactericidal activity against gram-positive and gram-negative bacteria, with potent inhibition in growth especially in the presence of simulated sunlight. The antibacterial properties of the CDs were tested on cellulose discs, demonstrating strong adherence and significant inhibition of bacterial cells. The cytotoxicity studies showed that these CDs, at concentrations up to 0.1 mg/mL, and the CD-modified fibers are benign to mammalian cells, emphasizing their safety for human use. Overall, the study concluded that PBA-PPCDs and BACDs are promising candidates for modifying fibers and inducing antimicrobial activity in fabrics made of cellulose fibers. |
| format | article |
| id | aus_dd5d448961c8969a11af2cd549fc67a8 |
| identifier_str_mv | Ravindran, S., Khan, D., Khodja, A. et al. Harnessing piperine for enhanced antimicrobial activity of carbon dot-modified cellulose fibers. Discov Appl Sci 6, 490 (2024). https://doi.org/10.1007/s42452-024-06187-4 3004-9261 10.1007/s42452-024-06187-4 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25583 |
| publishDate | 2024 |
| publisher.none.fl_str_mv | Springer |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Harnessing piperine for enhanced antimicrobial activity of carbon dot‑modified cellulose fibersRavindran, SreeshnaKhan, DanyahKhodja, AbdelhamidTerro, TalaRadha, RemyaDiab, RashaIalyshev, VadimAl‑Sayah, Mohammad H.Carbon dotsCellulosePiperineBoronic acidAntimicrobial fibersStaphylococcus epidermidisEscherichia coliSerratia marcescensMTTCell viabilitySelf-disinfecting fabricsMicrobial infections are a global health challenge often treated with antibiotics, but their overuse can lead to antibiotic resistance. To address this, there is a need for more efficient personal protective equipment (PPE) with novel antimicrobial techniques. One such technique involves using carbon dots (CDs) to create self-disinfecting fabrics. This study focused on synthesizing phenylboronic-acid-functionalized piperine-based carbon dots (PBA-PPCDs) and boronic acid carbon dots (BACDs) as potential antimicrobial agents. The materials were successfully synthesized using a hydrothermal method and characterized using various techniques to confirm the size, charge, fluorescence properties, and inner morphology of the CDs. The CDs showed bactericidal activity against gram-positive and gram-negative bacteria, with potent inhibition in growth especially in the presence of simulated sunlight. The antibacterial properties of the CDs were tested on cellulose discs, demonstrating strong adherence and significant inhibition of bacterial cells. The cytotoxicity studies showed that these CDs, at concentrations up to 0.1 mg/mL, and the CD-modified fibers are benign to mammalian cells, emphasizing their safety for human use. Overall, the study concluded that PBA-PPCDs and BACDs are promising candidates for modifying fibers and inducing antimicrobial activity in fabrics made of cellulose fibers.American University of SharjahAbu Dhabi National Oil Company (ADNOC)Emirates NBDSharjah Electricity Water & Gas Authority (SEWA)Technology Innovation Institute (TII)GSKSpringer2024-09-16T07:01:34Z2024-09-16T07:01:34Z2024Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfRavindran, S., Khan, D., Khodja, A. et al. Harnessing piperine for enhanced antimicrobial activity of carbon dot-modified cellulose fibers. Discov Appl Sci 6, 490 (2024). https://doi.org/10.1007/s42452-024-06187-43004-9261https://hdl.handle.net/11073/2558310.1007/s42452-024-06187-4en_UShttps://doi.org/10.1007/s42452-024-06187-4oai:repository.aus.edu:11073/255832024-09-16T15:44:29Z |
| spellingShingle | Harnessing piperine for enhanced antimicrobial activity of carbon dot‑modified cellulose fibers Ravindran, Sreeshna Carbon dots Cellulose Piperine Boronic acid Antimicrobial fibers Staphylococcus epidermidis Escherichia coli Serratia marcescens MTT Cell viability Self-disinfecting fabrics |
| status_str | publishedVersion |
| title | Harnessing piperine for enhanced antimicrobial activity of carbon dot‑modified cellulose fibers |
| title_full | Harnessing piperine for enhanced antimicrobial activity of carbon dot‑modified cellulose fibers |
| title_fullStr | Harnessing piperine for enhanced antimicrobial activity of carbon dot‑modified cellulose fibers |
| title_full_unstemmed | Harnessing piperine for enhanced antimicrobial activity of carbon dot‑modified cellulose fibers |
| title_short | Harnessing piperine for enhanced antimicrobial activity of carbon dot‑modified cellulose fibers |
| title_sort | Harnessing piperine for enhanced antimicrobial activity of carbon dot‑modified cellulose fibers |
| topic | Carbon dots Cellulose Piperine Boronic acid Antimicrobial fibers Staphylococcus epidermidis Escherichia coli Serratia marcescens MTT Cell viability Self-disinfecting fabrics |
| url | https://hdl.handle.net/11073/25583 |