Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy
Cancer therapies have advanced tremendously throughout the last decade, yet multiple factors still hinder the success of the different cancer therapeutics. The traditional therapeutic approach has been proven insufficient and lacking in the suppression of tumor growth. The simultaneous delivery of m...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
2022
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/24066 |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513432483528704 |
|---|---|
| author | Al Bostami, Rouba D. |
| author2 | Abuwatfa, Waad Hussein Husseini, Ghaleb |
| author2_role | author author |
| author_facet | Al Bostami, Rouba D. Abuwatfa, Waad Hussein Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Al Bostami, Rouba D. Abuwatfa, Waad Hussein Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2022-08-04T11:19:49Z 2022-08-04T11:19:49Z 2022-08 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Al Bostami, R.D.; Abuwatfa, W.H.; Husseini, G.A. Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy. Nanomaterials 2022, 12, 2672. https://doi.org/10.3390/nano12152672 2079-4991 http://hdl.handle.net/11073/24066 10.3390/nano12152672 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/nano12152672 |
| dc.subject.none.fl_str_mv | Co-delivery Multi-drug resistance Nanocarriers Gene delivery |
| dc.title.none.fl_str_mv | Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Cancer therapies have advanced tremendously throughout the last decade, yet multiple factors still hinder the success of the different cancer therapeutics. The traditional therapeutic approach has been proven insufficient and lacking in the suppression of tumor growth. The simultaneous delivery of multiple small-molecule chemotherapeutic drugs and genes improves the effectiveness of each treatment, thus optimizing efficacy and improving synergistic effects. Nanomedicines integrating inorganic, lipid, and polymeric-based nanoparticles have been designed to regulate the spatiotemporal release of the encapsulated drugs. Multidrug-loaded nanocarriers are a potential strategy to fight cancer and the incorporation of co-delivery systems as a feasible treatment method has projected synergistic benefits and limited undesirable effects. Moreover, the development of codelivery systems for maximum therapeutic impact necessitates better knowledge of the appropriate therapeutic agent ratio as well as the inherent heterogeneity of the cancer cells. Co-delivery systems can simplify clinical processes and increase patient quality of life, even though such systems are more difficult to prepare than single drug delivery systems. This review highlights the progress attained in the development and design of nano carrier-based co-delivery systems and discusses the limitations, challenges, and future perspectives in the design and fabrication of co-delivery systems. |
| format | article |
| id | aus_e07fe39c57e7aba4e10acacfbe471e35 |
| identifier_str_mv | Al Bostami, R.D.; Abuwatfa, W.H.; Husseini, G.A. Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy. Nanomaterials 2022, 12, 2672. https://doi.org/10.3390/nano12152672 2079-4991 10.3390/nano12152672 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/24066 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer TherapyAl Bostami, Rouba D.Abuwatfa, Waad HusseinHusseini, GhalebCo-deliveryMulti-drug resistanceNanocarriersGene deliveryCancer therapies have advanced tremendously throughout the last decade, yet multiple factors still hinder the success of the different cancer therapeutics. The traditional therapeutic approach has been proven insufficient and lacking in the suppression of tumor growth. The simultaneous delivery of multiple small-molecule chemotherapeutic drugs and genes improves the effectiveness of each treatment, thus optimizing efficacy and improving synergistic effects. Nanomedicines integrating inorganic, lipid, and polymeric-based nanoparticles have been designed to regulate the spatiotemporal release of the encapsulated drugs. Multidrug-loaded nanocarriers are a potential strategy to fight cancer and the incorporation of co-delivery systems as a feasible treatment method has projected synergistic benefits and limited undesirable effects. Moreover, the development of codelivery systems for maximum therapeutic impact necessitates better knowledge of the appropriate therapeutic agent ratio as well as the inherent heterogeneity of the cancer cells. Co-delivery systems can simplify clinical processes and increase patient quality of life, even though such systems are more difficult to prepare than single drug delivery systems. This review highlights the progress attained in the development and design of nano carrier-based co-delivery systems and discusses the limitations, challenges, and future perspectives in the design and fabrication of co-delivery systems.Dana Gas Endowed Chair for Chemical EngineeringAmerican University of SharjahSheikh Hamdan Award for Medical SciencesFriends of Cancer Patients (FoCP)MDPI2022-08-04T11:19:49Z2022-08-04T11:19:49Z2022-08Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAl Bostami, R.D.; Abuwatfa, W.H.; Husseini, G.A. Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy. Nanomaterials 2022, 12, 2672. https://doi.org/10.3390/nano121526722079-4991http://hdl.handle.net/11073/2406610.3390/nano12152672en_UShttps://doi.org/10.3390/nano12152672oai:repository.aus.edu:11073/240662024-08-22T12:04:29Z |
| spellingShingle | Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy Al Bostami, Rouba D. Co-delivery Multi-drug resistance Nanocarriers Gene delivery |
| status_str | publishedVersion |
| title | Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy |
| title_full | Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy |
| title_fullStr | Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy |
| title_full_unstemmed | Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy |
| title_short | Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy |
| title_sort | Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy |
| topic | Co-delivery Multi-drug resistance Nanocarriers Gene delivery |
| url | http://hdl.handle.net/11073/24066 |