AEO‑7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos
Background: Fatty alcohol polyoxyethylene ether-7 (AEO-7), a non-ionic surfactant, has recently been receiving extensive attention from the ocean pipeline industry for its ability to inhibit corrosion. However, the present lack of information concerning the potential environmental toxicity of AEO-7,...
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| مؤلفون آخرون: | , , , , , , , , |
| التنسيق: | article |
| منشور في: |
2020
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21445 |
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إضافة وسم
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| _version_ | 1864513438009524224 |
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| author | Al‑Asmakh, Maha |
| author2 | Majdalawieh, Amin Abdullah, Aboubakr M. Younes, Nadin Da’as, Sahar I. Radwan, A. Bahgat Sliem, Mostafa H. Ech‑Cherif, Houria Pintus, Gianfranco Nasrallah, Gheyath K. |
| author2_role | author author author author author author author author author |
| author_facet | Al‑Asmakh, Maha Majdalawieh, Amin Abdullah, Aboubakr M. Younes, Nadin Da’as, Sahar I. Radwan, A. Bahgat Sliem, Mostafa H. Ech‑Cherif, Houria Pintus, Gianfranco Nasrallah, Gheyath K. |
| author_role | author |
| dc.creator.none.fl_str_mv | Al‑Asmakh, Maha Majdalawieh, Amin Abdullah, Aboubakr M. Younes, Nadin Da’as, Sahar I. Radwan, A. Bahgat Sliem, Mostafa H. Ech‑Cherif, Houria Pintus, Gianfranco Nasrallah, Gheyath K. |
| dc.date.none.fl_str_mv | 2020 2021-04-26T09:19:08Z 2021-04-26T09:19:08Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Al-Asmakh, M., Majdalawieh, A.F., Abdullah, A.M. et al. AEO-7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos. Environ Sci Eur 32, 149 (2020). https://doi.org/10.1186/s12302-020-00429-z 2190-4715 http://hdl.handle.net/11073/21445 10.1186/s12302-020-00429-z |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Springer Open |
| dc.relation.none.fl_str_mv | https://doi.org/10.1186/s12302-020-00429-z |
| dc.subject.none.fl_str_mv | AEO-7 surfactant Cardiotoxicity Neurotoxicity Hepatotoxicity Zebrafish embryos |
| dc.title.none.fl_str_mv | AEO‑7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background: Fatty alcohol polyoxyethylene ether-7 (AEO-7), a non-ionic surfactant, has recently been receiving extensive attention from the ocean pipeline industry for its ability to inhibit corrosion. However, the present lack of information concerning the potential environmental toxicity of AEO-7, especially towards aquatic organisms, is a major impediment to its wider application. Here, we assess potential adverse effects of AEO-7 on zebrafish embryos employing a variety of assays, including (i) a mortality/survival assay which allowed the median lethal concentration (LC₅₀) to be calculated; (ii) a teratogenicity assay on the basis of which the no observed effect concentration (NOEC) was determined; and (iii) specific assays of cardiotoxicity, neurotoxicity (based on locomotion), hematopoietic toxicity (the level of hemoglobin as revealed by o-dianisidine staining) and hepatotoxicity (liver steatosis and yolk retention examined by staining with Oil Red O). Results: AEO-7 caused mortality with a calculated LC₅₀ of 15.35 μg/L, which, according to the U.S. Fish and Wildlife Service (USFWS) Acute Toxicity Rating scale, should be considered “super toxic”. Although at its NOEC (0.8 μg/L), there were no signs of significant teratogenicity, cardiotoxicity, or hemopoiesis toxicity, 3.2 µg/L AEO-7 exerted dramatic detrimental effects on organ development. Conclusion: On the basis of these findings, we recommend that the industrial usage and environmental impact of AEO-7 be re-evaluated and strictly monitored by environmental and public health organizations. |
| format | article |
| id | aus_e31bcbb0f08de22e33b85ae8cb048204 |
| identifier_str_mv | Al-Asmakh, M., Majdalawieh, A.F., Abdullah, A.M. et al. AEO-7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos. Environ Sci Eur 32, 149 (2020). https://doi.org/10.1186/s12302-020-00429-z 2190-4715 10.1186/s12302-020-00429-z |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21445 |
| publishDate | 2020 |
| publisher.none.fl_str_mv | Springer Open |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | AEO‑7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryosAl‑Asmakh, MahaMajdalawieh, AminAbdullah, Aboubakr M.Younes, NadinDa’as, Sahar I.Radwan, A. BahgatSliem, Mostafa H.Ech‑Cherif, HouriaPintus, GianfrancoNasrallah, Gheyath K.AEO-7 surfactantCardiotoxicityNeurotoxicityHepatotoxicityZebrafish embryosBackground: Fatty alcohol polyoxyethylene ether-7 (AEO-7), a non-ionic surfactant, has recently been receiving extensive attention from the ocean pipeline industry for its ability to inhibit corrosion. However, the present lack of information concerning the potential environmental toxicity of AEO-7, especially towards aquatic organisms, is a major impediment to its wider application. Here, we assess potential adverse effects of AEO-7 on zebrafish embryos employing a variety of assays, including (i) a mortality/survival assay which allowed the median lethal concentration (LC₅₀) to be calculated; (ii) a teratogenicity assay on the basis of which the no observed effect concentration (NOEC) was determined; and (iii) specific assays of cardiotoxicity, neurotoxicity (based on locomotion), hematopoietic toxicity (the level of hemoglobin as revealed by o-dianisidine staining) and hepatotoxicity (liver steatosis and yolk retention examined by staining with Oil Red O). Results: AEO-7 caused mortality with a calculated LC₅₀ of 15.35 μg/L, which, according to the U.S. Fish and Wildlife Service (USFWS) Acute Toxicity Rating scale, should be considered “super toxic”. Although at its NOEC (0.8 μg/L), there were no signs of significant teratogenicity, cardiotoxicity, or hemopoiesis toxicity, 3.2 µg/L AEO-7 exerted dramatic detrimental effects on organ development. Conclusion: On the basis of these findings, we recommend that the industrial usage and environmental impact of AEO-7 be re-evaluated and strictly monitored by environmental and public health organizations.Qatar UniversityQatar National Research FundSpringer Open2021-04-26T09:19:08Z2021-04-26T09:19:08Z2020Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAl-Asmakh, M., Majdalawieh, A.F., Abdullah, A.M. et al. AEO-7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos. Environ Sci Eur 32, 149 (2020). https://doi.org/10.1186/s12302-020-00429-z2190-4715http://hdl.handle.net/11073/2144510.1186/s12302-020-00429-zen_UShttps://doi.org/10.1186/s12302-020-00429-zoai:repository.aus.edu:11073/214452024-08-22T11:59:56Z |
| spellingShingle | AEO‑7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos Al‑Asmakh, Maha AEO-7 surfactant Cardiotoxicity Neurotoxicity Hepatotoxicity Zebrafish embryos |
| status_str | publishedVersion |
| title | AEO‑7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos |
| title_full | AEO‑7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos |
| title_fullStr | AEO‑7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos |
| title_full_unstemmed | AEO‑7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos |
| title_short | AEO‑7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos |
| title_sort | AEO‑7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos |
| topic | AEO-7 surfactant Cardiotoxicity Neurotoxicity Hepatotoxicity Zebrafish embryos |
| url | http://hdl.handle.net/11073/21445 |