Degradation kinetics of stabilized Pluronic micelles under the action of ultrasound
The majority of research in the area of acoustically-activated drug delivery from stabilized micelles has been focused on the rapid release of chemotherapy drugs from the core of such nano-carriers. Previous publications have shown that low-frequency ultrasound is able to release approximately 2% of...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2009
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21281 |
| الوسوم: |
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| _version_ | 1864513441628160000 |
|---|---|
| author | Husseini, Ghaleb |
| author2 | Pitt, William G. Christensen, Douglas A. Dickinson, David J. |
| author2_role | author author author |
| author_facet | Husseini, Ghaleb Pitt, William G. Christensen, Douglas A. Dickinson, David J. |
| author_role | author |
| dc.creator.none.fl_str_mv | Husseini, Ghaleb Pitt, William G. Christensen, Douglas A. Dickinson, David J. |
| dc.date.none.fl_str_mv | 2009 2021-01-26T07:49:36Z 2021-01-26T07:49:36Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Ghaleb A. Husseini, William G. Pitt, Douglas A. Christensen, David J. Dickinson, Degradation kinetics of stabilized Pluronic micelles under the action of ultrasound, Journal of Controlled Release, Volume 138, Issue 1, 2009, Pages 45-48, ISSN 0168-3659, https://doi.org/10.1016/j.jconrel.2009.04.018. 0168-3659 http://hdl.handle.net/11073/21281 10.1016/j.jconrel.2009.04.018 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.relation.none.fl_str_mv | https://doi.org/10.1016/j.jconrel.2009.04.018 |
| dc.subject.none.fl_str_mv | Ultrasound Fluorescence detection Stabilized micelles Drug release Degradation kinetics |
| dc.title.none.fl_str_mv | Degradation kinetics of stabilized Pluronic micelles under the action of ultrasound |
| dc.type.none.fl_str_mv | Peer-Reviewed Postprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The majority of research in the area of acoustically-activated drug delivery from stabilized micelles has been focused on the rapid release of chemotherapy drugs from the core of such nano-carriers. Previous publications have shown that low-frequency ultrasound is able to release approximately 2% of Doxorubicin (Dox) from the core of Pluronic P105 micelles stabilized using a cross-linked network of N,N-diethylacrylamide (NanoDeliv™) within 2 s of applying 70-kHz ultrasound. Here we use a custom-made ultrasound exposure chamber with fluorescence detection to measure the long-term fluorescence emissions of Dox from the NanoDeliv™ after 2 h of exposure to two ultrasound frequencies, 70 and 476 kHz, at a mechanical index of 0.9. Fluorescence measurements are then used to deduce the degradation kinetics of stabilized Pluronic micelles during 24 h following exposure to ultrasound. Results show that ultrasound does disrupt the covalent network of the stabilized micelles, but the time constant of network degradation is very long compared to the time constant pertaining to drug release from micelles. Experiments also show no significant difference in degradation rates when employing the two frequencies in question at the same mechanical index. |
| format | article |
| id | aus_efabbd449d3cb37d20fb0c4ebb92dc43 |
| identifier_str_mv | Ghaleb A. Husseini, William G. Pitt, Douglas A. Christensen, David J. Dickinson, Degradation kinetics of stabilized Pluronic micelles under the action of ultrasound, Journal of Controlled Release, Volume 138, Issue 1, 2009, Pages 45-48, ISSN 0168-3659, https://doi.org/10.1016/j.jconrel.2009.04.018. 0168-3659 10.1016/j.jconrel.2009.04.018 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21281 |
| publishDate | 2009 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Degradation kinetics of stabilized Pluronic micelles under the action of ultrasoundHusseini, GhalebPitt, William G.Christensen, Douglas A.Dickinson, David J.UltrasoundFluorescence detectionStabilized micellesDrug releaseDegradation kineticsThe majority of research in the area of acoustically-activated drug delivery from stabilized micelles has been focused on the rapid release of chemotherapy drugs from the core of such nano-carriers. Previous publications have shown that low-frequency ultrasound is able to release approximately 2% of Doxorubicin (Dox) from the core of Pluronic P105 micelles stabilized using a cross-linked network of N,N-diethylacrylamide (NanoDeliv™) within 2 s of applying 70-kHz ultrasound. Here we use a custom-made ultrasound exposure chamber with fluorescence detection to measure the long-term fluorescence emissions of Dox from the NanoDeliv™ after 2 h of exposure to two ultrasound frequencies, 70 and 476 kHz, at a mechanical index of 0.9. Fluorescence measurements are then used to deduce the degradation kinetics of stabilized Pluronic micelles during 24 h following exposure to ultrasound. Results show that ultrasound does disrupt the covalent network of the stabilized micelles, but the time constant of network degradation is very long compared to the time constant pertaining to drug release from micelles. Experiments also show no significant difference in degradation rates when employing the two frequencies in question at the same mechanical index.Elsevier2021-01-26T07:49:36Z2021-01-26T07:49:36Z2009Peer-ReviewedPostprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfGhaleb A. Husseini, William G. Pitt, Douglas A. Christensen, David J. Dickinson, Degradation kinetics of stabilized Pluronic micelles under the action of ultrasound, Journal of Controlled Release, Volume 138, Issue 1, 2009, Pages 45-48, ISSN 0168-3659, https://doi.org/10.1016/j.jconrel.2009.04.018.0168-3659http://hdl.handle.net/11073/2128110.1016/j.jconrel.2009.04.018en_UShttps://doi.org/10.1016/j.jconrel.2009.04.018oai:repository.aus.edu:11073/212812024-08-22T12:05:03Z |
| spellingShingle | Degradation kinetics of stabilized Pluronic micelles under the action of ultrasound Husseini, Ghaleb Ultrasound Fluorescence detection Stabilized micelles Drug release Degradation kinetics |
| status_str | publishedVersion |
| title | Degradation kinetics of stabilized Pluronic micelles under the action of ultrasound |
| title_full | Degradation kinetics of stabilized Pluronic micelles under the action of ultrasound |
| title_fullStr | Degradation kinetics of stabilized Pluronic micelles under the action of ultrasound |
| title_full_unstemmed | Degradation kinetics of stabilized Pluronic micelles under the action of ultrasound |
| title_short | Degradation kinetics of stabilized Pluronic micelles under the action of ultrasound |
| title_sort | Degradation kinetics of stabilized Pluronic micelles under the action of ultrasound |
| topic | Ultrasound Fluorescence detection Stabilized micelles Drug release Degradation kinetics |
| url | http://hdl.handle.net/11073/21281 |