Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review
Efficient conventional chemotherapy is limited by its nonspecific nature, which causes severe systemic toxicity that can lead to patient discomfort and low therapeutic efficacy. The emergence of smart drug delivery systems (SDDSs) utilizing nanoparticles as drug nanocarriers has shown great potentia...
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2022
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| Online Access: | http://hdl.handle.net/11073/24083 |
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| _version_ | 1864513432939659264 |
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| author | Bahutair, Wafa N. |
| author2 | Abuwatfa, Waad Hussein Husseini, Ghaleb |
| author2_role | author author |
| author_facet | Bahutair, Wafa N. Abuwatfa, Waad Hussein Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Bahutair, Wafa N. Abuwatfa, Waad Hussein Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2022-09-05T05:46:46Z 2022-09-05T05:46:46Z 2022 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Bahutair, W.N.; Abuwatfa, W.H.; Husseini, G.A. Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review. Nanomaterials 2022, 12, 3051. https:// doi.org/10.3390/nano12173051. [Comment: This article belongs to the Special Issue Supramolecular Nanomaterials for Biomedical Application] 2079-4991 http://hdl.handle.net/11073/24083 10.3390/nano12173051 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https:// doi.org/10.3390/nano12173051 |
| dc.subject.none.fl_str_mv | Liposomes Passive targeting Active targeting Receptor-mediated endocytosis Ultrasound Triggered release |
| dc.title.none.fl_str_mv | Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Efficient conventional chemotherapy is limited by its nonspecific nature, which causes severe systemic toxicity that can lead to patient discomfort and low therapeutic efficacy. The emergence of smart drug delivery systems (SDDSs) utilizing nanoparticles as drug nanocarriers has shown great potential in enhancing the targetability of anticancer agents and limiting their side effects. Liposomes are among the most investigated nanoplatforms due to their promising capabilities of encapsulating hydrophilic, lipophilic, and amphiphilic drugs, biocompatibility, physicochemical and biophysical properties. Liposomal nanodrug systems have demonstrated the ability to alter drugs’ biodistribution by sufficiently delivering the entrapped chemotherapeutics at the targeted diseased sites, sparing normal cells from undesired cytotoxic effects. Combining liposomal treatments with ultrasound, as an external drug release triggering modality, has been proven effective in spatially and temporally controlling and stimulating drug release. Therefore, this paper reviews recent literature pertaining to the therapeutic synergy of triggering nanodrugs from liposomes using ultrasound. It also highlights the effects of multiple physical and chemical factors on liposomes’ sonosensetivity, several ultrasound-induced drug release mechanisms, and the efficacy of ultrasound-responsive liposomal systems in cancer therapy. Overall, liposomal nanodrug systems triggered by ultrasound are promising cancer therapy platforms that can potentially alleviate the detriments of conventional cancer treatments. |
| format | article |
| id | aus_f0a1a42b3d704dcb8d2de03a568fb42e |
| identifier_str_mv | Bahutair, W.N.; Abuwatfa, W.H.; Husseini, G.A. Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review. Nanomaterials 2022, 12, 3051. https:// doi.org/10.3390/nano12173051. [Comment: This article belongs to the Special Issue Supramolecular Nanomaterials for Biomedical Application] 2079-4991 10.3390/nano12173051 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/24083 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A ReviewBahutair, Wafa N.Abuwatfa, Waad HusseinHusseini, GhalebLiposomesPassive targetingActive targetingReceptor-mediated endocytosisUltrasoundTriggered releaseEfficient conventional chemotherapy is limited by its nonspecific nature, which causes severe systemic toxicity that can lead to patient discomfort and low therapeutic efficacy. The emergence of smart drug delivery systems (SDDSs) utilizing nanoparticles as drug nanocarriers has shown great potential in enhancing the targetability of anticancer agents and limiting their side effects. Liposomes are among the most investigated nanoplatforms due to their promising capabilities of encapsulating hydrophilic, lipophilic, and amphiphilic drugs, biocompatibility, physicochemical and biophysical properties. Liposomal nanodrug systems have demonstrated the ability to alter drugs’ biodistribution by sufficiently delivering the entrapped chemotherapeutics at the targeted diseased sites, sparing normal cells from undesired cytotoxic effects. Combining liposomal treatments with ultrasound, as an external drug release triggering modality, has been proven effective in spatially and temporally controlling and stimulating drug release. Therefore, this paper reviews recent literature pertaining to the therapeutic synergy of triggering nanodrugs from liposomes using ultrasound. It also highlights the effects of multiple physical and chemical factors on liposomes’ sonosensetivity, several ultrasound-induced drug release mechanisms, and the efficacy of ultrasound-responsive liposomal systems in cancer therapy. Overall, liposomal nanodrug systems triggered by ultrasound are promising cancer therapy platforms that can potentially alleviate the detriments of conventional cancer treatments.Dana Gas Endowed Chair for Chemical EngineeringAmerican University of SharjahSheikh Hamdan Award for Medical SciencesFriends of Cancer PatientsMDPI2022-09-05T05:46:46Z2022-09-05T05:46:46Z2022Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfBahutair, W.N.; Abuwatfa, W.H.; Husseini, G.A. Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review. Nanomaterials 2022, 12, 3051. https:// doi.org/10.3390/nano12173051. [Comment: This article belongs to the Special Issue Supramolecular Nanomaterials for Biomedical Application]2079-4991http://hdl.handle.net/11073/2408310.3390/nano12173051en_UShttps:// doi.org/10.3390/nano12173051oai:repository.aus.edu:11073/240832024-08-22T12:04:51Z |
| spellingShingle | Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review Bahutair, Wafa N. Liposomes Passive targeting Active targeting Receptor-mediated endocytosis Ultrasound Triggered release |
| status_str | publishedVersion |
| title | Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review |
| title_full | Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review |
| title_fullStr | Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review |
| title_full_unstemmed | Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review |
| title_short | Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review |
| title_sort | Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review |
| topic | Liposomes Passive targeting Active targeting Receptor-mediated endocytosis Ultrasound Triggered release |
| url | http://hdl.handle.net/11073/24083 |