Factors affecting acoustically triggered release of drugs from polymeric micelles
A custom ultrasonic exposure chamber with real-time fluorescence detection was used to measure acoustically-triggered drug release from Pluronic P-105 micelles under continuous wave (CW) or pulsed ultrasound in the frequency range of 20 to 90 kHz. The measurements were based on the decrease in fluor...
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| مؤلفون آخرون: | , , , |
| التنسيق: | article |
| منشور في: |
2000
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/19828 |
| الوسوم: |
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| _version_ | 1864513437536616448 |
|---|---|
| author | Husseini, Ghaleb |
| author2 | Myrup, Gregg D. Pitt, William G. Christensen, Douglas A. Rapoport, Natalya Y. |
| author2_role | author author author author |
| author_facet | Husseini, Ghaleb Myrup, Gregg D. Pitt, William G. Christensen, Douglas A. Rapoport, Natalya Y. |
| author_role | author |
| dc.creator.none.fl_str_mv | Husseini, Ghaleb Myrup, Gregg D. Pitt, William G. Christensen, Douglas A. Rapoport, Natalya Y. |
| dc.date.none.fl_str_mv | 2000 2020-12-17T06:03:53Z 2020-12-17T06:03:53Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Husseini, G. A., Myrup, G. D., Pitt, W. G., Christensen, D. A., & Rapoport, N. Y. (2000). Factors affecting acoustically triggered release of drugs from polymeric micelles. Journal of Controlled Release, 69(1), 43–52. https://doi.org/10.1016/s0168-3659(00)00278-9 0168-3659 http://hdl.handle.net/11073/19828 10.1016/S0168-3659(00)00278-9 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.relation.none.fl_str_mv | https://doi.org/10.1016/S0168-3659(00)00278-9 |
| dc.subject.none.fl_str_mv | Polymeric micelles Triggered release Ultrasound Pluronic Micellization Drug delivery Doxorubicin Ruboxyl |
| dc.title.none.fl_str_mv | Factors affecting acoustically triggered release of drugs from polymeric micelles |
| dc.type.none.fl_str_mv | Peer-Reviewed Postprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | A custom ultrasonic exposure chamber with real-time fluorescence detection was used to measure acoustically-triggered drug release from Pluronic P-105 micelles under continuous wave (CW) or pulsed ultrasound in the frequency range of 20 to 90 kHz. The measurements were based on the decrease in fluorescence intensity when drug was transferred from the micelle core to the aqueous environment. Two fluorescent drugs were used: doxorubicin (DOX) and its paramagnetic analogue, ruboxyl (Rb). Pluronic P-105 at various concentrations in aqueous solutions was used as a micelle-forming polymer. Drug release was most efficient at 20-kHz ultrasound and dropped with increasing ultrasonic frequency despite much higher power densities. These data suggest an important role of transient cavitation in drug release. The release of DOX was higher than that of Rb due to stronger interaction and deeper insertion of Rb into the core of the micelles. Drug release was higher at lower Pluronic concentrations, which presumably resulted from higher local drug concentrations in the core of Pluronic micelles when the number of micelles was low. At constant frequency, drug release increased with increasing power density. At constant power density and for pulse duration longer than 0.1 s, peak release under pulsed ultrasound was the same as stationary release under CW ultrasound. Released drug was quickly re-encapsulated between the pulses of ultrasound, which suggests that upon leaving the sonicated volume, the non-extravasated and non-internalized drug would circulate in the encapsulated form, thus preventing unwanted drug interactions with normal tissues. |
| format | article |
| id | aus_f3512f8f397ce9a9b942316bf09fe4e6 |
| identifier_str_mv | Husseini, G. A., Myrup, G. D., Pitt, W. G., Christensen, D. A., & Rapoport, N. Y. (2000). Factors affecting acoustically triggered release of drugs from polymeric micelles. Journal of Controlled Release, 69(1), 43–52. https://doi.org/10.1016/s0168-3659(00)00278-9 0168-3659 10.1016/S0168-3659(00)00278-9 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/19828 |
| publishDate | 2000 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Factors affecting acoustically triggered release of drugs from polymeric micellesHusseini, GhalebMyrup, Gregg D.Pitt, William G.Christensen, Douglas A.Rapoport, Natalya Y.Polymeric micellesTriggered releaseUltrasoundPluronicMicellizationDrug deliveryDoxorubicinRuboxylA custom ultrasonic exposure chamber with real-time fluorescence detection was used to measure acoustically-triggered drug release from Pluronic P-105 micelles under continuous wave (CW) or pulsed ultrasound in the frequency range of 20 to 90 kHz. The measurements were based on the decrease in fluorescence intensity when drug was transferred from the micelle core to the aqueous environment. Two fluorescent drugs were used: doxorubicin (DOX) and its paramagnetic analogue, ruboxyl (Rb). Pluronic P-105 at various concentrations in aqueous solutions was used as a micelle-forming polymer. Drug release was most efficient at 20-kHz ultrasound and dropped with increasing ultrasonic frequency despite much higher power densities. These data suggest an important role of transient cavitation in drug release. The release of DOX was higher than that of Rb due to stronger interaction and deeper insertion of Rb into the core of the micelles. Drug release was higher at lower Pluronic concentrations, which presumably resulted from higher local drug concentrations in the core of Pluronic micelles when the number of micelles was low. At constant frequency, drug release increased with increasing power density. At constant power density and for pulse duration longer than 0.1 s, peak release under pulsed ultrasound was the same as stationary release under CW ultrasound. Released drug was quickly re-encapsulated between the pulses of ultrasound, which suggests that upon leaving the sonicated volume, the non-extravasated and non-internalized drug would circulate in the encapsulated form, thus preventing unwanted drug interactions with normal tissues.Elsevier2020-12-17T06:03:53Z2020-12-17T06:03:53Z2000Peer-ReviewedPostprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfHusseini, G. A., Myrup, G. D., Pitt, W. G., Christensen, D. A., & Rapoport, N. Y. (2000). Factors affecting acoustically triggered release of drugs from polymeric micelles. Journal of Controlled Release, 69(1), 43–52. https://doi.org/10.1016/s0168-3659(00)00278-90168-3659http://hdl.handle.net/11073/1982810.1016/S0168-3659(00)00278-9en_UShttps://doi.org/10.1016/S0168-3659(00)00278-9oai:repository.aus.edu:11073/198282024-08-22T12:05:24Z |
| spellingShingle | Factors affecting acoustically triggered release of drugs from polymeric micelles Husseini, Ghaleb Polymeric micelles Triggered release Ultrasound Pluronic Micellization Drug delivery Doxorubicin Ruboxyl |
| status_str | publishedVersion |
| title | Factors affecting acoustically triggered release of drugs from polymeric micelles |
| title_full | Factors affecting acoustically triggered release of drugs from polymeric micelles |
| title_fullStr | Factors affecting acoustically triggered release of drugs from polymeric micelles |
| title_full_unstemmed | Factors affecting acoustically triggered release of drugs from polymeric micelles |
| title_short | Factors affecting acoustically triggered release of drugs from polymeric micelles |
| title_sort | Factors affecting acoustically triggered release of drugs from polymeric micelles |
| topic | Polymeric micelles Triggered release Ultrasound Pluronic Micellization Drug delivery Doxorubicin Ruboxyl |
| url | http://hdl.handle.net/11073/19828 |