Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review
Doxorubicin (DOX) is one of the most widely used anthracycline anticancer drugs due to its high efficacy and evident antitumoral activity on several cancer types. However, its effective utilization is hindered by the adverse side effects associated with its administration, the detriment to the patie...
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2022
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| Online Access: | http://hdl.handle.net/11073/21609 |
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| _version_ | 1864513433288835072 |
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| author | Ibrahim, Mihad |
| author2 | Abuwatfa, Waad Hussein Awad, Nahid S. Sabouni, Rana Husseini, Ghaleb |
| author2_role | author author author author |
| author_facet | Ibrahim, Mihad Abuwatfa, Waad Hussein Awad, Nahid S. Sabouni, Rana Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Ibrahim, Mihad Abuwatfa, Waad Hussein Awad, Nahid S. Sabouni, Rana Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2022-01-27T04:38:29Z 2022-01-27T04:38:29Z 2022 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Ibrahim, M.; Abuwatfa, W.H.; Awad, N.S.; Sabouni, R.; Husseini, G.A. Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review. Pharmaceutics 2022, 14, 254. https://doi.org/10.3390/ pharmaceutics14020254 1999-4923 http://hdl.handle.net/11073/21609 10.3390/pharmaceutics14020254 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/pharmaceutics14020254 |
| dc.subject.none.fl_str_mv | Doxorubicin Liposomes Micelles Metal-organic frameworks (MOFs) |
| dc.title.none.fl_str_mv | Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Doxorubicin (DOX) is one of the most widely used anthracycline anticancer drugs due to its high efficacy and evident antitumoral activity on several cancer types. However, its effective utilization is hindered by the adverse side effects associated with its administration, the detriment to the patients’ quality of life, and general toxicity to healthy fast-dividing cells. Thus, delivering DOX to the tumor site encapsulated inside nanocarrier-based systems is an area of research that has garnered colossal interest in targeted medicine. Nanoparticles can be used as vehicles for the localized delivery and release of DOX, decreasing the effects on neighboring healthy cells and providing more control over the drug’s release and distribution. This review presents an overview of DOX-based nanocarrier delivery systems, covering loading methods, release rate, and the cytotoxicity of liposomal, micellar, and metal organic frameworks (MOFs) platforms. |
| format | article |
| id | aus_f4d2b60a2612dcdb8add8e17fcae6212 |
| identifier_str_mv | Ibrahim, M.; Abuwatfa, W.H.; Awad, N.S.; Sabouni, R.; Husseini, G.A. Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review. Pharmaceutics 2022, 14, 254. https://doi.org/10.3390/ pharmaceutics14020254 1999-4923 10.3390/pharmaceutics14020254 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21609 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
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| spelling | Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A ReviewIbrahim, MihadAbuwatfa, Waad HusseinAwad, Nahid S.Sabouni, RanaHusseini, GhalebDoxorubicinLiposomesMicellesMetal-organic frameworks (MOFs)Doxorubicin (DOX) is one of the most widely used anthracycline anticancer drugs due to its high efficacy and evident antitumoral activity on several cancer types. However, its effective utilization is hindered by the adverse side effects associated with its administration, the detriment to the patients’ quality of life, and general toxicity to healthy fast-dividing cells. Thus, delivering DOX to the tumor site encapsulated inside nanocarrier-based systems is an area of research that has garnered colossal interest in targeted medicine. Nanoparticles can be used as vehicles for the localized delivery and release of DOX, decreasing the effects on neighboring healthy cells and providing more control over the drug’s release and distribution. This review presents an overview of DOX-based nanocarrier delivery systems, covering loading methods, release rate, and the cytotoxicity of liposomal, micellar, and metal organic frameworks (MOFs) platforms.Dana Gas Endowed Chair for Chemical EngineeringAmerican University of SharjahSheikh Hamdan Award for Medical SciencesMDPI2022-01-27T04:38:29Z2022-01-27T04:38:29Z2022Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfIbrahim, M.; Abuwatfa, W.H.; Awad, N.S.; Sabouni, R.; Husseini, G.A. Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review. Pharmaceutics 2022, 14, 254. https://doi.org/10.3390/ pharmaceutics140202541999-4923http://hdl.handle.net/11073/2160910.3390/pharmaceutics14020254en_UShttps://doi.org/10.3390/pharmaceutics14020254oai:repository.aus.edu:11073/216092024-08-22T12:05:00Z |
| spellingShingle | Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review Ibrahim, Mihad Doxorubicin Liposomes Micelles Metal-organic frameworks (MOFs) |
| status_str | publishedVersion |
| title | Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review |
| title_full | Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review |
| title_fullStr | Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review |
| title_full_unstemmed | Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review |
| title_short | Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review |
| title_sort | Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review |
| topic | Doxorubicin Liposomes Micelles Metal-organic frameworks (MOFs) |
| url | http://hdl.handle.net/11073/21609 |