The role of cavitation in acoustically activated drug delivery
Pluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from these polymeric carriers. In this study, an ultrasonic exposure chamber with flu...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , |
| التنسيق: | article |
| منشور في: |
2005
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21270 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513434136084480 |
|---|---|
| author | Husseini, Ghaleb |
| author2 | Diaz de la Rosa, Mario A. Richardson, Eric S. Christensen, Douglas A. Pitt, William G. |
| author2_role | author author author author |
| author_facet | Husseini, Ghaleb Diaz de la Rosa, Mario A. Richardson, Eric S. Christensen, Douglas A. Pitt, William G. |
| author_role | author |
| dc.creator.none.fl_str_mv | Husseini, Ghaleb Diaz de la Rosa, Mario A. Richardson, Eric S. Christensen, Douglas A. Pitt, William G. |
| dc.date.none.fl_str_mv | 2005 2021-01-14T06:37:15Z 2021-01-14T06:37:15Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Ghaleb A. Husseini, Mario A. Diaz de la Rosa, Eric S. Richardson, Douglas A. Christensen, William G. Pitt, The role of cavitation in acoustically activated drug delivery, Journal of Controlled Release, Volume 107, Issue 2, 2005, Pages 253-261, ISSN 0168-3659, https://doi.org/10.1016/j.jconrel.2005.06.015. 0168-3659 http://hdl.handle.net/11073/21270 10.1016/j.jconrel.2005.06.015 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Elsevier Science Direct |
| dc.relation.none.fl_str_mv | https://doi.org/10.1016/j.jconrel.2005.06.015 |
| dc.subject.none.fl_str_mv | Doxorubicin Pluronic micelles Fluorescence measurements Cavitation events Acoustic spectroscopy |
| dc.title.none.fl_str_mv | The role of cavitation in acoustically activated drug delivery |
| dc.type.none.fl_str_mv | Peer-Reviewed Postprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Pluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from these polymeric carriers. In this study, an ultrasonic exposure chamber with fluorescence detection was used to examine the mechanism of doxorubicin release from P105 micelles. Acoustic spectra were collected and analyzed, at the same spatial position as fluorescence data, to probe the role of cavitation in drug release. Our study showed a strong correlation between percent drug release and subharmonic acoustic emissions, and we attribute the drug release to collapse cavitation that perturbs the structure of the micelle and releases drug. |
| format | article |
| id | aus_fd195ae0087ef6ffede1d1896ea0c803 |
| identifier_str_mv | Ghaleb A. Husseini, Mario A. Diaz de la Rosa, Eric S. Richardson, Douglas A. Christensen, William G. Pitt, The role of cavitation in acoustically activated drug delivery, Journal of Controlled Release, Volume 107, Issue 2, 2005, Pages 253-261, ISSN 0168-3659, https://doi.org/10.1016/j.jconrel.2005.06.015. 0168-3659 10.1016/j.jconrel.2005.06.015 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21270 |
| publishDate | 2005 |
| publisher.none.fl_str_mv | Elsevier Science Direct |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | The role of cavitation in acoustically activated drug deliveryHusseini, GhalebDiaz de la Rosa, Mario A.Richardson, Eric S.Christensen, Douglas A.Pitt, William G.DoxorubicinPluronic micellesFluorescence measurementsCavitation eventsAcoustic spectroscopyPluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from these polymeric carriers. In this study, an ultrasonic exposure chamber with fluorescence detection was used to examine the mechanism of doxorubicin release from P105 micelles. Acoustic spectra were collected and analyzed, at the same spatial position as fluorescence data, to probe the role of cavitation in drug release. Our study showed a strong correlation between percent drug release and subharmonic acoustic emissions, and we attribute the drug release to collapse cavitation that perturbs the structure of the micelle and releases drug.Elsevier Science Direct2021-01-14T06:37:15Z2021-01-14T06:37:15Z2005Peer-ReviewedPostprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfGhaleb A. Husseini, Mario A. Diaz de la Rosa, Eric S. Richardson, Douglas A. Christensen, William G. Pitt, The role of cavitation in acoustically activated drug delivery, Journal of Controlled Release, Volume 107, Issue 2, 2005, Pages 253-261, ISSN 0168-3659, https://doi.org/10.1016/j.jconrel.2005.06.015.0168-3659http://hdl.handle.net/11073/2127010.1016/j.jconrel.2005.06.015en_UShttps://doi.org/10.1016/j.jconrel.2005.06.015oai:repository.aus.edu:11073/212702024-08-22T12:05:41Z |
| spellingShingle | The role of cavitation in acoustically activated drug delivery Husseini, Ghaleb Doxorubicin Pluronic micelles Fluorescence measurements Cavitation events Acoustic spectroscopy |
| status_str | publishedVersion |
| title | The role of cavitation in acoustically activated drug delivery |
| title_full | The role of cavitation in acoustically activated drug delivery |
| title_fullStr | The role of cavitation in acoustically activated drug delivery |
| title_full_unstemmed | The role of cavitation in acoustically activated drug delivery |
| title_short | The role of cavitation in acoustically activated drug delivery |
| title_sort | The role of cavitation in acoustically activated drug delivery |
| topic | Doxorubicin Pluronic micelles Fluorescence measurements Cavitation events Acoustic spectroscopy |
| url | http://hdl.handle.net/11073/21270 |