A Comprehensive Review of Smart Thermosensitive Nanocarriers for Precision Cancer Therapy
By 2030, millions of new cancer cases will be diagnosed, as well as millions of cancer-related deaths. Traditional drug delivery methods have limitations, so developing smart drug delivery systems (SDDs) has emerged as a promising avenue for more effective and precise cancer treatment. Nanotechnolog...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2025
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://hdl.handle.net/11073/33242 |
| الوسوم: |
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| _version_ | 1864513431815585792 |
|---|---|
| author | Yaramiri, Atena |
| author2 | Abo Asalh, Rand Abo Asalh, Majd AlSawaftah, Nour Abuwatfa, Waad H. Husseini, Ghaleb |
| author2_role | author author author author author |
| author_facet | Yaramiri, Atena Abo Asalh, Rand Abo Asalh, Majd AlSawaftah, Nour Abuwatfa, Waad H. Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Yaramiri, Atena Abo Asalh, Rand Abo Asalh, Majd AlSawaftah, Nour Abuwatfa, Waad H. Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2025 2026-03-10T08:20:30Z 2026-03-10T08:20:30Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Yaramiri, A.; Asalh, R.A.; Asalh, M.A.; AlSawaftah, N.; Abuwatfa,W.H.; Husseini, G.A. A Comprehensive Review of Smart Thermosensitive Nanocarriers for Precision Cancer Therapy. Int. J. Mol. Sci. 2025, 26, 7322. https://doi.org/ 10.3390/ijms26157322 1422-0067 https://hdl.handle.net/11073/33242 10.3390/ijms26157322 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/ijms26157322 |
| dc.subject.none.fl_str_mv | Thermosensitive nanocarriers Drug delivery Nanotechnology Hyperthermia Cancer treatment Smart drug delivery systems |
| dc.title.none.fl_str_mv | A Comprehensive Review of Smart Thermosensitive Nanocarriers for Precision Cancer Therapy |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | By 2030, millions of new cancer cases will be diagnosed, as well as millions of cancer-related deaths. Traditional drug delivery methods have limitations, so developing smart drug delivery systems (SDDs) has emerged as a promising avenue for more effective and precise cancer treatment. Nanotechnology, particularly nanomedicine, provides innovative approaches to enhance drug delivery, including the use of nanoparticles. One such type of SDD is thermosensitive nanoparticles, which respond to internal and external stimuli, such as temperature changes, to release drugs precisely at tumor sites and minimize off-target effects. On the other hand, hyperthermia is a cancer treatment mode that goes back centuries and has become popular because it can target cancer cells while sparing healthy tissue. This paper presents a comprehensive review of smart thermosensitive nanoparticles for cancer treatment, with a primary focus on organic nanoparticles. The integration of hyperthermia with temperature-sensitive nanocarriers, such as micelles, hydrogels, dendrimers, liposomes, and solid lipid nanoparticles, offers a promising approach to improving the precision and efficacy of cancer therapy. By leveraging temperature as a controlled drug release mechanism, this review highlights the potential of these innovative systems to enhance treatment outcomes while minimizing adverse side effects. |
| format | article |
| id | aus_fd1ac998085155f26b7418ffd16140b9 |
| identifier_str_mv | Yaramiri, A.; Asalh, R.A.; Asalh, M.A.; AlSawaftah, N.; Abuwatfa,W.H.; Husseini, G.A. A Comprehensive Review of Smart Thermosensitive Nanocarriers for Precision Cancer Therapy. Int. J. Mol. Sci. 2025, 26, 7322. https://doi.org/ 10.3390/ijms26157322 1422-0067 10.3390/ijms26157322 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/33242 |
| publishDate | 2025 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | A Comprehensive Review of Smart Thermosensitive Nanocarriers for Precision Cancer TherapyYaramiri, AtenaAbo Asalh, RandAbo Asalh, MajdAlSawaftah, NourAbuwatfa, Waad H.Husseini, GhalebThermosensitive nanocarriersDrug deliveryNanotechnologyHyperthermiaCancer treatmentSmart drug delivery systemsBy 2030, millions of new cancer cases will be diagnosed, as well as millions of cancer-related deaths. Traditional drug delivery methods have limitations, so developing smart drug delivery systems (SDDs) has emerged as a promising avenue for more effective and precise cancer treatment. Nanotechnology, particularly nanomedicine, provides innovative approaches to enhance drug delivery, including the use of nanoparticles. One such type of SDD is thermosensitive nanoparticles, which respond to internal and external stimuli, such as temperature changes, to release drugs precisely at tumor sites and minimize off-target effects. On the other hand, hyperthermia is a cancer treatment mode that goes back centuries and has become popular because it can target cancer cells while sparing healthy tissue. This paper presents a comprehensive review of smart thermosensitive nanoparticles for cancer treatment, with a primary focus on organic nanoparticles. The integration of hyperthermia with temperature-sensitive nanocarriers, such as micelles, hydrogels, dendrimers, liposomes, and solid lipid nanoparticles, offers a promising approach to improving the precision and efficacy of cancer therapy. By leveraging temperature as a controlled drug release mechanism, this review highlights the potential of these innovative systems to enhance treatment outcomes while minimizing adverse side effects.Dana Gas Endowed Chair for Chemical EngineeringAmerican University of SharjahSheikh Hamdan Award for Medical SciencesFriends of Cancer Patients (FoCP)MDPI2026-03-10T08:20:30Z2026-03-10T08:20:30Z2025Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfYaramiri, A.; Asalh, R.A.; Asalh, M.A.; AlSawaftah, N.; Abuwatfa,W.H.; Husseini, G.A. A Comprehensive Review of Smart Thermosensitive Nanocarriers for Precision Cancer Therapy. Int. J. Mol. Sci. 2025, 26, 7322. https://doi.org/ 10.3390/ijms261573221422-0067https://hdl.handle.net/11073/3324210.3390/ijms26157322en_UShttps://doi.org/10.3390/ijms26157322oai:repository.aus.edu:11073/332422026-03-11T05:24:06Z |
| spellingShingle | A Comprehensive Review of Smart Thermosensitive Nanocarriers for Precision Cancer Therapy Yaramiri, Atena Thermosensitive nanocarriers Drug delivery Nanotechnology Hyperthermia Cancer treatment Smart drug delivery systems |
| status_str | publishedVersion |
| title | A Comprehensive Review of Smart Thermosensitive Nanocarriers for Precision Cancer Therapy |
| title_full | A Comprehensive Review of Smart Thermosensitive Nanocarriers for Precision Cancer Therapy |
| title_fullStr | A Comprehensive Review of Smart Thermosensitive Nanocarriers for Precision Cancer Therapy |
| title_full_unstemmed | A Comprehensive Review of Smart Thermosensitive Nanocarriers for Precision Cancer Therapy |
| title_short | A Comprehensive Review of Smart Thermosensitive Nanocarriers for Precision Cancer Therapy |
| title_sort | A Comprehensive Review of Smart Thermosensitive Nanocarriers for Precision Cancer Therapy |
| topic | Thermosensitive nanocarriers Drug delivery Nanotechnology Hyperthermia Cancer treatment Smart drug delivery systems |
| url | https://hdl.handle.net/11073/33242 |