Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression
Signaling involving chemokine receptor CXCR4 and its ligand SDF-1/CXL12 has been investigated for many years for its possible role in cancer progression and pathogenesis. Evidence emerging from clinical studies in recent years has further established diagnostic as well as prognostic importance of CX...
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| مؤلفون آخرون: | , , , , , , , |
| التنسيق: | article |
| منشور في: |
2022
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.semcancer.2022.03.019 https://www.sciencedirect.com/science/article/pii/S1044579X2200075X http://hdl.handle.net/10576/48859 |
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| _version_ | 1857415090283741184 |
|---|---|
| author | Reem Khaled M.E., Alsayed |
| author2 | Khan, Abdul Q. Ahmad, Fareed Ansari, Abdul Wahid Alam, Majid Ali Buddenkotte, Jorg Steinhoff, Martin Uddin, Shahab Ahmad, Aamir |
| author2_role | author author author author author author author author |
| author_facet | Reem Khaled M.E., Alsayed Khan, Abdul Q. Ahmad, Fareed Ansari, Abdul Wahid Alam, Majid Ali Buddenkotte, Jorg Steinhoff, Martin Uddin, Shahab Ahmad, Aamir |
| author_role | author |
| dc.creator.none.fl_str_mv | Reem Khaled M.E., Alsayed Khan, Abdul Q. Ahmad, Fareed Ansari, Abdul Wahid Alam, Majid Ali Buddenkotte, Jorg Steinhoff, Martin Uddin, Shahab Ahmad, Aamir |
| dc.date.none.fl_str_mv | 2022-11-30 2023-10-30T05:25:57Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.semcancer.2022.03.019 1044579X https://www.sciencedirect.com/science/article/pii/S1044579X2200075X http://hdl.handle.net/10576/48859 697-708 2 86 1096-3650 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | CXCR SDF-1/CXCL12 Epigenetic Non-coding RNA Methylation/acetylation |
| dc.title.none.fl_str_mv | Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Signaling involving chemokine receptor CXCR4 and its ligand SDF-1/CXL12 has been investigated for many years for its possible role in cancer progression and pathogenesis. Evidence emerging from clinical studies in recent years has further established diagnostic as well as prognostic importance of CXCR4 signaling. CXCR4 and SDF-1 are routinely reported to be elevated in tumors, distant metastases, which correlates with poor survival of patients. These findings have kindled interest in the mechanisms that regulate CXCR4/SDF-1 expression. Of note, there is a particular interest in the epigenetic regulation of CXCR4 signaling that may be responsible for upregulated CXCR4 in primary as well as metastatic cancers. This review first lists the clinical evidence supporting CXCR4 signaling as putative cancer diagnostic and/or prognostic biomarker, followed by a discussion on reported epigenetic mechanisms that affect CXCR4 expression. These mechanisms include regulation by non-coding RNAs, such as, microRNAs, long non-coding RNAs and circular RNAs. Additionally, we also discuss the regulation of CXCR4 expression through methylation and acetylation. Better understanding and appreciation of epigenetic regulation of CXCR4 signaling can invariably lead to identification of novel therapeutic targets as well as therapies to regulate this oncogenic signaling. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_082c2e605d134d0c4487dea01fbf4401 |
| identifier_str_mv | 1044579X 697-708 2 86 1096-3650 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/48859 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progressionReem Khaled M.E., AlsayedKhan, Abdul Q.Ahmad, FareedAnsari, Abdul WahidAlam, Majid AliBuddenkotte, JorgSteinhoff, MartinUddin, ShahabAhmad, AamirCXCRSDF-1/CXCL12EpigeneticNon-coding RNAMethylation/acetylationSignaling involving chemokine receptor CXCR4 and its ligand SDF-1/CXL12 has been investigated for many years for its possible role in cancer progression and pathogenesis. Evidence emerging from clinical studies in recent years has further established diagnostic as well as prognostic importance of CXCR4 signaling. CXCR4 and SDF-1 are routinely reported to be elevated in tumors, distant metastases, which correlates with poor survival of patients. These findings have kindled interest in the mechanisms that regulate CXCR4/SDF-1 expression. Of note, there is a particular interest in the epigenetic regulation of CXCR4 signaling that may be responsible for upregulated CXCR4 in primary as well as metastatic cancers. This review first lists the clinical evidence supporting CXCR4 signaling as putative cancer diagnostic and/or prognostic biomarker, followed by a discussion on reported epigenetic mechanisms that affect CXCR4 expression. These mechanisms include regulation by non-coding RNAs, such as, microRNAs, long non-coding RNAs and circular RNAs. Additionally, we also discuss the regulation of CXCR4 expression through methylation and acetylation. Better understanding and appreciation of epigenetic regulation of CXCR4 signaling can invariably lead to identification of novel therapeutic targets as well as therapies to regulate this oncogenic signaling.Open Access funding for this article has been provided by the Qatar National Library.Elsevier2023-10-30T05:25:57Z2022-11-30Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.semcancer.2022.03.0191044579Xhttps://www.sciencedirect.com/science/article/pii/S1044579X2200075Xhttp://hdl.handle.net/10576/48859697-7082861096-3650enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/488592024-07-23T15:51:48Z |
| spellingShingle | Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression Reem Khaled M.E., Alsayed CXCR SDF-1/CXCL12 Epigenetic Non-coding RNA Methylation/acetylation |
| status_str | publishedVersion |
| title | Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression |
| title_full | Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression |
| title_fullStr | Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression |
| title_full_unstemmed | Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression |
| title_short | Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression |
| title_sort | Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression |
| topic | CXCR SDF-1/CXCL12 Epigenetic Non-coding RNA Methylation/acetylation |
| url | http://dx.doi.org/10.1016/j.semcancer.2022.03.019 https://www.sciencedirect.com/science/article/pii/S1044579X2200075X http://hdl.handle.net/10576/48859 |