Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling
Aortic valve diseases are among the most common cardiovascular defects. Since a non-functioning valve results in disturbed blood flow conditions, the diagnosis of such defects is based on identification of stenosis via echocardiography. Calculation of disease parameters such as valve orifice area or...
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2017
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| Online Access: | http://dx.doi.org/10.1016/j.imu.2017.09.001 http://www.sciencedirect.com/science/article/pii/S2352914817300369 http://hdl.handle.net/10576/5724 |
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| _version_ | 1857415086766817280 |
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| author | Amindari, Armin |
| author2 | Saltik, Levent Kirkkopru, Kadir Yacoub, Magdi Yalcin, Huseyin C. |
| author2_role | author author author author |
| author_facet | Amindari, Armin Saltik, Levent Kirkkopru, Kadir Yacoub, Magdi Yalcin, Huseyin C. |
| author_role | author |
| dc.creator.none.fl_str_mv | Amindari, Armin Saltik, Levent Kirkkopru, Kadir Yacoub, Magdi Yalcin, Huseyin C. |
| dc.date.none.fl_str_mv | 2017-11-01T07:01:58Z 2017 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.imu.2017.09.001 Armin Amindari, Levent Saltik, Kadir Kirkkopru, Magdi Yacoub, Huseyin C. Yalcin, "Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling", Informatics in Medicine Unlocked, Volume 9, 2017, Pages 191-199 23529148 http://www.sciencedirect.com/science/article/pii/S2352914817300369 http://hdl.handle.net/10576/5724 191-199 9 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Aortic valve Calcification Computational fluid dynamics Fluid-structure interaction ANSYS FLUENT MECHANICAL APDL Stenosis Echocardiography |
| dc.title.none.fl_str_mv | Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Aortic valve diseases are among the most common cardiovascular defects. Since a non-functioning valve results in disturbed blood flow conditions, the diagnosis of such defects is based on identification of stenosis via echocardiography. Calculation of disease parameters such as valve orifice area or transvalvular pressure gradient using echocardiography is associated with substantial errors. Computational fluid dynamics (CFD) modeling has emerged as an alternative approach for accurate assessment of aortic valve hemodynamics. Fluid-structure interaction (FSI) modeling is adapted in these models to account for counter-interacting forces of flowing blood and deforming leaflets for most accurate results. However, implementation of this approach is difficult using custom built codes and algorithms. In this paper, we present an FSI modeling methodology for aortic valve hemodynamics using a commercial modeling software, ANSYS. We simulated the problem using fluid flow solver FLUENT and structural solver MECHANICAL APDL under ANSYS and coupled the solutions using System Coupling Module to enable FSI. This approach minimized adaptation problems that would raise if separate solvers were used. As an example case, we investigated influence of leaflet calcification on hemodynamic stresses and flow patterns. Model geometries were generated using b-mode echocardiography images of an aortic valve. A Doppler velocity measurement was used as velocity inlet boundary condition in the models. Simulation results were validated by comparing leaflet movements in the simulations with b-mode echo recordings. Wall shear stress levels, pressure levels and flow patterns agree well with previous studies demonstrating the accuracy of our results. Our modeling methodology can be easily adopted by researchers that are familiar with ANSYS and other similar CFD software to investigate similar biomedical problems. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_117697985ba108ec5465217b60b42f07 |
| identifier_str_mv | Armin Amindari, Levent Saltik, Kadir Kirkkopru, Magdi Yacoub, Huseyin C. Yalcin, "Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling", Informatics in Medicine Unlocked, Volume 9, 2017, Pages 191-199 23529148 191-199 9 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/5724 |
| publishDate | 2017 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| spelling | Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modelingAmindari, ArminSaltik, LeventKirkkopru, KadirYacoub, MagdiYalcin, Huseyin C.Aortic valveCalcificationComputational fluid dynamicsFluid-structure interactionANSYSFLUENTMECHANICAL APDLStenosisEchocardiographyAortic valve diseases are among the most common cardiovascular defects. Since a non-functioning valve results in disturbed blood flow conditions, the diagnosis of such defects is based on identification of stenosis via echocardiography. Calculation of disease parameters such as valve orifice area or transvalvular pressure gradient using echocardiography is associated with substantial errors. Computational fluid dynamics (CFD) modeling has emerged as an alternative approach for accurate assessment of aortic valve hemodynamics. Fluid-structure interaction (FSI) modeling is adapted in these models to account for counter-interacting forces of flowing blood and deforming leaflets for most accurate results. However, implementation of this approach is difficult using custom built codes and algorithms. In this paper, we present an FSI modeling methodology for aortic valve hemodynamics using a commercial modeling software, ANSYS. We simulated the problem using fluid flow solver FLUENT and structural solver MECHANICAL APDL under ANSYS and coupled the solutions using System Coupling Module to enable FSI. This approach minimized adaptation problems that would raise if separate solvers were used. As an example case, we investigated influence of leaflet calcification on hemodynamic stresses and flow patterns. Model geometries were generated using b-mode echocardiography images of an aortic valve. A Doppler velocity measurement was used as velocity inlet boundary condition in the models. Simulation results were validated by comparing leaflet movements in the simulations with b-mode echo recordings. Wall shear stress levels, pressure levels and flow patterns agree well with previous studies demonstrating the accuracy of our results. Our modeling methodology can be easily adopted by researchers that are familiar with ANSYS and other similar CFD software to investigate similar biomedical problems.This research was supported by a Marie Curie International Reintegration Grant within the Seventh European Community Framework Programme (IRG276987 to HCY) and by The Scientific and Technological Research Council of Turkey, Tubitak (112M148 to HCY and 112M895 to HCY).Elsevier2017-11-01T07:01:58Z2017Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.imu.2017.09.001Armin Amindari, Levent Saltik, Kadir Kirkkopru, Magdi Yacoub, Huseyin C. Yalcin, "Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling", Informatics in Medicine Unlocked, Volume 9, 2017, Pages 191-19923529148http://www.sciencedirect.com/science/article/pii/S2352914817300369http://hdl.handle.net/10576/5724191-1999enhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/57242024-07-23T15:54:20Z |
| spellingShingle | Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling Amindari, Armin Aortic valve Calcification Computational fluid dynamics Fluid-structure interaction ANSYS FLUENT MECHANICAL APDL Stenosis Echocardiography |
| status_str | publishedVersion |
| title | Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling |
| title_full | Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling |
| title_fullStr | Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling |
| title_full_unstemmed | Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling |
| title_short | Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling |
| title_sort | Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling |
| topic | Aortic valve Calcification Computational fluid dynamics Fluid-structure interaction ANSYS FLUENT MECHANICAL APDL Stenosis Echocardiography |
| url | http://dx.doi.org/10.1016/j.imu.2017.09.001 http://www.sciencedirect.com/science/article/pii/S2352914817300369 http://hdl.handle.net/10576/5724 |