Demographic characteristics and clinical and laboratory features of patients with Clostridiodes difficile infection: A retrospective study in Qatar
ObjectivesClostridioides difficile infection (CDI) is one of the most common causes of diarrhea in healthcare facilities, imposing a significant burden on health-related budgets and resources worldwide. We aimed to study the demographic features, laboratory findings, and outcomes of CDI in Qatar. Me...
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| مؤلفون آخرون: | , , , , , , , , , , |
| التنسيق: | article |
| منشور في: |
2025
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.ijregi.2025.100592 https://www.sciencedirect.com/science/article/pii/S277270762500027X http://hdl.handle.net/10576/64023 |
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| _version_ | 1857415083834998784 |
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| author | Vamanjore A., Naushad |
| author2 | Purayil, Nishan K. Varikkodan, Irfan Badi, Ahmed M. Baghi, Mohamed A. Chandra, Prem Alarbi, Khaled M.S. Althani, Maryam K. Aboughalia, Ahmed T. Farooqi, Amer Kartha, Anand B. Elzouki, Abdelnaser |
| author2_role | author author author author author author author author author author author |
| author_facet | Vamanjore A., Naushad Purayil, Nishan K. Varikkodan, Irfan Badi, Ahmed M. Baghi, Mohamed A. Chandra, Prem Alarbi, Khaled M.S. Althani, Maryam K. Aboughalia, Ahmed T. Farooqi, Amer Kartha, Anand B. Elzouki, Abdelnaser |
| author_role | author |
| dc.creator.none.fl_str_mv | Vamanjore A., Naushad Purayil, Nishan K. Varikkodan, Irfan Badi, Ahmed M. Baghi, Mohamed A. Chandra, Prem Alarbi, Khaled M.S. Althani, Maryam K. Aboughalia, Ahmed T. Farooqi, Amer Kartha, Anand B. Elzouki, Abdelnaser |
| dc.date.none.fl_str_mv | 2025-03-27T10:18:50Z 2025-03-31 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.ijregi.2025.100592 27727076 https://www.sciencedirect.com/science/article/pii/S277270762500027X http://hdl.handle.net/10576/64023 14 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Clostridium Clostridiodes difficile C. diff CDI Antibiotics PPI |
| dc.title.none.fl_str_mv | Demographic characteristics and clinical and laboratory features of patients with Clostridiodes difficile infection: A retrospective study in Qatar |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | ObjectivesClostridioides difficile infection (CDI) is one of the most common causes of diarrhea in healthcare facilities, imposing a significant burden on health-related budgets and resources worldwide. We aimed to study the demographic features, laboratory findings, and outcomes of CDI in Qatar. MethodsA retrospective study involving adult patients with a confirmed diagnosis of CDI was conducted. ResultsOf the 595 patients, 308 (51.8%) were men with a mean age of 58 ± 19.9 years. The median duration of symptoms was 2 days, with an interquartile range values of 2-4 days. The most common symptoms reported were diarrhea (90.6%) and abdominal pain (41.5%). A total of 426 (71.6%) and 422 (70.9%) patients had a history of exposure to antibiotics and proton pump inhibitors, respectively, while 461 (77.7%) patients had a history of contact with a healthcare facility in the prior 3 months. Respiratory tract infections (33.9%) and urinary tract infections (22.4%) were the most common indications for antibiotic use in the study population. Increased C-reactive protein levels were the most frequently observed laboratory findings. Sepsis was identified as the most common complication (10.4 %). Reinfection was observed in 75 (12.6%) patients. Vancomycin monotherapy was the most commonly prescribed treatment. ConclusionsIn Qatar, CDI remains a significant health concern, primarily affecting elderly men, especially those who have had hospital admissions or used proton pump inhibitors or antibiotics. Preventive measures and increased knowledge of contact precautions and hand hygiene, particularly among healthcare workers, will help to reduce transmission. Raising physician awareness regarding the prudent use of antibiotics and antibiotic stewardship will serve as an adjunct to reduce the incidence of CDIs. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_21a5e2682c75457d9323e5dbd0440ac3 |
| identifier_str_mv | 27727076 14 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/64023 |
| publishDate | 2025 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| spelling | Demographic characteristics and clinical and laboratory features of patients with Clostridiodes difficile infection: A retrospective study in QatarVamanjore A., NaushadPurayil, Nishan K.Varikkodan, IrfanBadi, Ahmed M.Baghi, Mohamed A.Chandra, PremAlarbi, Khaled M.S.Althani, Maryam K.Aboughalia, Ahmed T.Farooqi, AmerKartha, Anand B.Elzouki, AbdelnaserClostridiumClostridiodes difficileC. diffCDIAntibioticsPPIObjectivesClostridioides difficile infection (CDI) is one of the most common causes of diarrhea in healthcare facilities, imposing a significant burden on health-related budgets and resources worldwide. We aimed to study the demographic features, laboratory findings, and outcomes of CDI in Qatar. MethodsA retrospective study involving adult patients with a confirmed diagnosis of CDI was conducted. ResultsOf the 595 patients, 308 (51.8%) were men with a mean age of 58 ± 19.9 years. The median duration of symptoms was 2 days, with an interquartile range values of 2-4 days. The most common symptoms reported were diarrhea (90.6%) and abdominal pain (41.5%). A total of 426 (71.6%) and 422 (70.9%) patients had a history of exposure to antibiotics and proton pump inhibitors, respectively, while 461 (77.7%) patients had a history of contact with a healthcare facility in the prior 3 months. Respiratory tract infections (33.9%) and urinary tract infections (22.4%) were the most common indications for antibiotic use in the study population. Increased C-reactive protein levels were the most frequently observed laboratory findings. Sepsis was identified as the most common complication (10.4 %). Reinfection was observed in 75 (12.6%) patients. Vancomycin monotherapy was the most commonly prescribed treatment. ConclusionsIn Qatar, CDI remains a significant health concern, primarily affecting elderly men, especially those who have had hospital admissions or used proton pump inhibitors or antibiotics. Preventive measures and increased knowledge of contact precautions and hand hygiene, particularly among healthcare workers, will help to reduce transmission. Raising physician awareness regarding the prudent use of antibiotics and antibiotic stewardship will serve as an adjunct to reduce the incidence of CDIs.Elsevier2025-03-27T10:18:50Z2025-03-31Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.ijregi.2025.10059227727076https://www.sciencedirect.com/science/article/pii/S277270762500027Xhttp://hdl.handle.net/10576/6402314enhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/640232025-03-27T19:07:22Z |
| spellingShingle | Demographic characteristics and clinical and laboratory features of patients with Clostridiodes difficile infection: A retrospective study in Qatar Vamanjore A., Naushad Clostridium Clostridiodes difficile C. diff CDI Antibiotics PPI |
| status_str | publishedVersion |
| title | Demographic characteristics and clinical and laboratory features of patients with Clostridiodes difficile infection: A retrospective study in Qatar |
| title_full | Demographic characteristics and clinical and laboratory features of patients with Clostridiodes difficile infection: A retrospective study in Qatar |
| title_fullStr | Demographic characteristics and clinical and laboratory features of patients with Clostridiodes difficile infection: A retrospective study in Qatar |
| title_full_unstemmed | Demographic characteristics and clinical and laboratory features of patients with Clostridiodes difficile infection: A retrospective study in Qatar |
| title_short | Demographic characteristics and clinical and laboratory features of patients with Clostridiodes difficile infection: A retrospective study in Qatar |
| title_sort | Demographic characteristics and clinical and laboratory features of patients with Clostridiodes difficile infection: A retrospective study in Qatar |
| topic | Clostridium Clostridiodes difficile C. diff CDI Antibiotics PPI |
| url | http://dx.doi.org/10.1016/j.ijregi.2025.100592 https://www.sciencedirect.com/science/article/pii/S277270762500027X http://hdl.handle.net/10576/64023 |