Topical treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials

Topical treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials

BackgroundAtopic dermatitis (AD) is a common skin condition with multiple topical treatment options, but uncertain comparative effects. ObjectiveWe sought to systematically synthesize the benefits and harms of AD prescription topical treatments. MethodsFor the 2023 American Academy of Allergy, Asthm...

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Main Author: Derek K., Chu (author)
Other Authors: Chu, Alexandro W.L. (author), Rayner, Daniel G. (author), Guyatt, Gordon H. (author), Yepes-Nuñez, Juan José (author), Gomez-Escobar, Luis (author), Pérez-Herrera, Lucia C. (author), Díaz Martinez, Juan Pablo (author), Brignardello-Petersen, Romina (author), Sadeghirad, Behnam (author), Wong, Melanie M. (author), Ceccacci, Renata (author), Zhao, Irene X. (author), Basmaji, John (author), MacDonald, Margaret (author), Chu, Xiajing (author), Islam, Nazmul (author), Gao, Ya (author), Izcovich, Ariel (author), Asiniwasis, Rachel N. (author), Boguniewicz, Mark (author), De Benedetto, Anna (author), Capozza, Korey (author), Chen, Lina (author), Ellison, Kathy (author), Frazier, Winfred T. (author), Greenhawt, Matthew (author), Huynh, Joey (author), LeBovidge, Jennifer (author), Lio, Peter A. (author), Martin, Stephen A. (author), O’Brien, Monica (author), Ong, Peck Y. (author), Silverberg, Jonathan I. (author), Spergel, Jonathan M. (author), Smith Begolka, Wendy (author), Wang, Julie (author), Wheeler, Kathryn E. (author), Gardner, Donna D. (author), Schneider, Lynda (author)
Format: article
Published: 2023
Subjects:
Atopic dermatitis (eczema)
topical treatments (therapy)
topical corticosteroids (steroids)
topical calcineurin inhibitors (pimecrolimus, tacrolimus)
topical phosphodiesterase-4 (PDE-4) inhibitors (crisaborole, difamilast, lotamilast, roflumilast)
topical Janus kinase (JAK) inhibitors (ruxolitinib, delgocitinib)
patient-important outcomes (eczema severity, intensity, itch, sleep, quality of life, flares or flare-ups or exacerbations)
disease severity
network meta-analysis (comparative effects)
induction of remission and maintenance of remission (reactive or proactive therapy)
Online Access:http://dx.doi.org/10.1016/j.jaci.2023.08.030
https://www.sciencedirect.com/science/article/pii/S0091674923011132
http://hdl.handle.net/10576/50632
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