Genome-wide association study identifies several loci for HEV seropositivity
Hepatitis E viral (HEV) infection imposes a heavy global health burden. The variability in the prevalence of serological markers of HEV infection between different ethnic groups proposes a host genetic influence. Here, we report genetic polymorphisms associated with anti-HEV antibody positivity and...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2023
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.isci.2023.107586 https://www.sciencedirect.com/science/article/pii/S2589004223016632 http://hdl.handle.net/10576/50062 |
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| _version_ | 1857415087560589312 |
|---|---|
| author | Maria K., Smatti |
| author2 | Al-Sarraj, Yasser A. Albagha, Omar Yassine, Hadi M. |
| author2_role | author author author |
| author_facet | Maria K., Smatti Al-Sarraj, Yasser A. Albagha, Omar Yassine, Hadi M. |
| author_role | author |
| dc.creator.none.fl_str_mv | Maria K., Smatti Al-Sarraj, Yasser A. Albagha, Omar Yassine, Hadi M. |
| dc.date.none.fl_str_mv | 2023-12-04T06:28:58Z 2023-09-15 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.isci.2023.107586 25890042 https://www.sciencedirect.com/science/article/pii/S2589004223016632 http://hdl.handle.net/10576/50062 9 26 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Association analysis Immune response Quantitative genetics Virology |
| dc.title.none.fl_str_mv | Genome-wide association study identifies several loci for HEV seropositivity |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Hepatitis E viral (HEV) infection imposes a heavy global health burden. The variability in the prevalence of serological markers of HEV infection between different ethnic groups proposes a host genetic influence. Here, we report genetic polymorphisms associated with anti-HEV antibody positivity and level using binary- and quantitative-trait genome-wide association studies (GWAS) on a population from Qatar (n = 5829). We identified a region in 12p11.1 (lead SNP: rs559856097, allele: A, p = 2.3 × 10−10) significantly associated with anti-HEV antibodies level. This intergenic variant is located near SNORD112, a small nucleolar RNA (snoRNA). Additional gene-set and pathway enrichment analyses highlighted a strong correlation with anti-viral response-related pathways, including IFNs (alpha/beta) and interleukin-21 (IL-21) signaling. This is the first GWAS on the response to HEV infection. Further replication and functional experimentation are warranted to validate these findings. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_2c4648ca983b944648140c5cc5a74e92 |
| identifier_str_mv | 25890042 9 26 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/50062 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Genome-wide association study identifies several loci for HEV seropositivityMaria K., SmattiAl-Sarraj, Yasser A.Albagha, OmarYassine, Hadi M.Association analysisImmune responseQuantitative geneticsVirologyHepatitis E viral (HEV) infection imposes a heavy global health burden. The variability in the prevalence of serological markers of HEV infection between different ethnic groups proposes a host genetic influence. Here, we report genetic polymorphisms associated with anti-HEV antibody positivity and level using binary- and quantitative-trait genome-wide association studies (GWAS) on a population from Qatar (n = 5829). We identified a region in 12p11.1 (lead SNP: rs559856097, allele: A, p = 2.3 × 10−10) significantly associated with anti-HEV antibodies level. This intergenic variant is located near SNORD112, a small nucleolar RNA (snoRNA). Additional gene-set and pathway enrichment analyses highlighted a strong correlation with anti-viral response-related pathways, including IFNs (alpha/beta) and interleukin-21 (IL-21) signaling. This is the first GWAS on the response to HEV infection. Further replication and functional experimentation are warranted to validate these findings.This study was funded by Qatar University High Impact Grant (Grant number: QUHI-BRC-20_21-1). The work makes use of data generated by the Qatar Genome Program (QGP) and Qatar Biobank (QBB), which are funded by Qatar foundation for Education, Science and Community.Elsevier2023-12-04T06:28:58Z2023-09-15Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.isci.2023.10758625890042https://www.sciencedirect.com/science/article/pii/S2589004223016632http://hdl.handle.net/10576/50062926enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/500622024-07-23T15:52:11Z |
| spellingShingle | Genome-wide association study identifies several loci for HEV seropositivity Maria K., Smatti Association analysis Immune response Quantitative genetics Virology |
| status_str | publishedVersion |
| title | Genome-wide association study identifies several loci for HEV seropositivity |
| title_full | Genome-wide association study identifies several loci for HEV seropositivity |
| title_fullStr | Genome-wide association study identifies several loci for HEV seropositivity |
| title_full_unstemmed | Genome-wide association study identifies several loci for HEV seropositivity |
| title_short | Genome-wide association study identifies several loci for HEV seropositivity |
| title_sort | Genome-wide association study identifies several loci for HEV seropositivity |
| topic | Association analysis Immune response Quantitative genetics Virology |
| url | http://dx.doi.org/10.1016/j.isci.2023.107586 https://www.sciencedirect.com/science/article/pii/S2589004223016632 http://hdl.handle.net/10576/50062 |