Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide.
The global burden of overweight and obesity has increased by threefold since the 1970s, which led to increased incidences of cardiovascular disease and type 2 diabetes. This review aimed to explore the metabolic impacts of semaglutide, including its effects on hunger and satiety, weight loss mainten...
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| مؤلفون آخرون: | |
| التنسيق: | article |
| منشور في: |
2025
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.clnesp.2025.03.010 https://www.sciencedirect.com/science/article/pii/S2405457725001019?v=s5 http://hdl.handle.net/10576/64004 |
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| _version_ | 1857415087552200704 |
|---|---|
| author | Sara, Sokary |
| author2 | Bawadi, Hiba |
| author2_role | author |
| author_facet | Sara, Sokary Bawadi, Hiba |
| author_role | author |
| dc.creator.none.fl_str_mv | Sara, Sokary Bawadi, Hiba |
| dc.date.none.fl_str_mv | 2025-03-27T06:47:46Z 2025-03-17 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.clnesp.2025.03.010 Sokary S, Bawadi H, Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide., Clinical Nutrition ESPEN, https://doi.org/10.1016/j.clnesp.2025.03.010. 24054577 https://www.sciencedirect.com/science/article/pii/S2405457725001019?v=s5 http://hdl.handle.net/10576/64004 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Body Composition Glucagon-Like Peptide-1 Receptor Agonist Glycemic Control Hunger and Satiety Lipid Profile Semaglutide Weight Maintenance |
| dc.title.none.fl_str_mv | Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide. |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The global burden of overweight and obesity has increased by threefold since the 1970s, which led to increased incidences of cardiovascular disease and type 2 diabetes. This review aimed to explore the metabolic impacts of semaglutide, including its effects on hunger and satiety, weight loss maintenance and regain, body composition, lipid profile, and glycemic control. Studies have shown that semaglutide reduced fat mass, particularly visceral fat, while preserving lean muscle mass, as the proportion relative to total body mass decreased by 3.5% and 2.0% for total and visceral fat mass, respectively, while it increased by 3.0% for lean body mass. Also, it enhanced glycemic control, as evidenced by significant reductions in hemoglobin A1C (HbA1c) with the 0.5 mg and 1.0 mg doses. From a baseline range of 8.1–8.7%, 0.5mg dose lowered HbA1c by 1.2–1.5%, while the 1.0 mg dose reduced it by 1.4–1.8%. Furthermore, semaglutide was the only effective Glucagon Like Peptide-1 Receptor Agonist in reducing Low-Density Lipoprotein and total cholesterol levels, with mean differences of -0.16 mmol/L and -0.48 mmol/L, respectively. Evidence shows that withdrawing semaglutide led to weight regain, while continued treatment resulted in further weight loss. Semaglutide also slowed weight regain and promoted weight loss after failed bariatric surgery. It also significantly reduced ad libitum energy intake, decreased hunger, and increased satiety in multiple trials. Overall, these findings underscore the potential of semaglutide as a comprehensive treatment for obesity and type 2 diabetes. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_30c360e15462399d7afda1091aa9c342 |
| identifier_str_mv | Sokary S, Bawadi H, Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide., Clinical Nutrition ESPEN, https://doi.org/10.1016/j.clnesp.2025.03.010. 24054577 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/64004 |
| publishDate | 2025 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide.Sara, SokaryBawadi, HibaBody CompositionGlucagon-Like Peptide-1 Receptor AgonistGlycemic ControlHunger and SatietyLipid ProfileSemaglutideWeight MaintenanceThe global burden of overweight and obesity has increased by threefold since the 1970s, which led to increased incidences of cardiovascular disease and type 2 diabetes. This review aimed to explore the metabolic impacts of semaglutide, including its effects on hunger and satiety, weight loss maintenance and regain, body composition, lipid profile, and glycemic control. Studies have shown that semaglutide reduced fat mass, particularly visceral fat, while preserving lean muscle mass, as the proportion relative to total body mass decreased by 3.5% and 2.0% for total and visceral fat mass, respectively, while it increased by 3.0% for lean body mass. Also, it enhanced glycemic control, as evidenced by significant reductions in hemoglobin A1C (HbA1c) with the 0.5 mg and 1.0 mg doses. From a baseline range of 8.1–8.7%, 0.5mg dose lowered HbA1c by 1.2–1.5%, while the 1.0 mg dose reduced it by 1.4–1.8%. Furthermore, semaglutide was the only effective Glucagon Like Peptide-1 Receptor Agonist in reducing Low-Density Lipoprotein and total cholesterol levels, with mean differences of -0.16 mmol/L and -0.48 mmol/L, respectively. Evidence shows that withdrawing semaglutide led to weight regain, while continued treatment resulted in further weight loss. Semaglutide also slowed weight regain and promoted weight loss after failed bariatric surgery. It also significantly reduced ad libitum energy intake, decreased hunger, and increased satiety in multiple trials. Overall, these findings underscore the potential of semaglutide as a comprehensive treatment for obesity and type 2 diabetes.Elsevier2025-03-27T06:47:46Z2025-03-17Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.clnesp.2025.03.010Sokary S, Bawadi H, Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide., Clinical Nutrition ESPEN, https://doi.org/10.1016/j.clnesp.2025.03.010.24054577https://www.sciencedirect.com/science/article/pii/S2405457725001019?v=s5http://hdl.handle.net/10576/64004enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/640042025-03-27T19:06:58Z |
| spellingShingle | Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide. Sara, Sokary Body Composition Glucagon-Like Peptide-1 Receptor Agonist Glycemic Control Hunger and Satiety Lipid Profile Semaglutide Weight Maintenance |
| status_str | publishedVersion |
| title | Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide. |
| title_full | Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide. |
| title_fullStr | Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide. |
| title_full_unstemmed | Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide. |
| title_short | Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide. |
| title_sort | Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide. |
| topic | Body Composition Glucagon-Like Peptide-1 Receptor Agonist Glycemic Control Hunger and Satiety Lipid Profile Semaglutide Weight Maintenance |
| url | http://dx.doi.org/10.1016/j.clnesp.2025.03.010 https://www.sciencedirect.com/science/article/pii/S2405457725001019?v=s5 http://hdl.handle.net/10576/64004 |