Epidemiology of herpes simplex virus type 1 in the United States: Systematic review, meta-analyses, and meta-regressions
This study aimed to analytically describe the epidemiology of herpes simplex virus type 1 (HSV-1) infection in the United States through a systematic review and meta-analytics. We reviewed 159 publications, identifying 190 seroprevalence measures and 43 proportions of HSV-1 detection in genital herp...
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2024
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| Online Access: | http://dx.doi.org/10.1016/j.isci.2024.110652 https://www.sciencedirect.com/science/article/pii/S2589004224018777 http://hdl.handle.net/10576/61320 |
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| _version_ | 1857415085225410560 |
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| author | Rwedah A., Ageeb |
| author2 | Harfouche, Manale Chemaitelly, Hiam Abu-Raddad, Laith J. |
| author2_role | author author author |
| author_facet | Rwedah A., Ageeb Harfouche, Manale Chemaitelly, Hiam Abu-Raddad, Laith J. |
| author_role | author |
| dc.creator.none.fl_str_mv | Rwedah A., Ageeb Harfouche, Manale Chemaitelly, Hiam Abu-Raddad, Laith J. |
| dc.date.none.fl_str_mv | 2024-11-19T11:15:49Z 2024-09-20 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.isci.2024.110652 Ageeb, R. A., Harfouche, M., Chemaitelly, H., & Abu-Raddad, L. J. (2024). Epidemiology of herpes simplex virus type 1 in the United States: Systematic review, meta-analyses, and meta-regressions. Iscience, 27(9). https://www.sciencedirect.com/science/article/pii/S2589004224018777 http://hdl.handle.net/10576/61320 9 27 2589-0042 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Health sciences Disease |
| dc.title.none.fl_str_mv | Epidemiology of herpes simplex virus type 1 in the United States: Systematic review, meta-analyses, and meta-regressions |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | This study aimed to analytically describe the epidemiology of herpes simplex virus type 1 (HSV-1) infection in the United States through a systematic review and meta-analytics. We reviewed 159 publications, identifying 190 seroprevalence measures and 43 proportions of HSV-1 detection in genital herpes. The pooled mean HSV-1 seroprevalence was 38.0% (95% CI: 30.9–45.4) among general-population children and 63.5% (95% CI: 61.3–65.7) among general-population adults. Age explained 43% of the seroprevalence variation, with rates increasing progressively with age. Seroprevalence declined by 0.99-fold (95% CI: 0.99–0.99) per year. The pooled mean proportion of HSV-1 detection in genital herpes was 15.4% (95% CI: 10.8–20.6), increasing by 1.02-fold (95% CI: 1.00–1.04) per year. Recurrent genital herpes had a 0.17-fold (95% CI: 0.09–0.32) lower proportion of HSV-1 detection compared to first-episode cases. The epidemiology of HSV-1 is shifting, marked by a decline in oral acquisition during childhood and an increase in genital acquisition during adulthood. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_39a89d41746033c4a5e49c9ceb8b52c0 |
| identifier_str_mv | Ageeb, R. A., Harfouche, M., Chemaitelly, H., & Abu-Raddad, L. J. (2024). Epidemiology of herpes simplex virus type 1 in the United States: Systematic review, meta-analyses, and meta-regressions. Iscience, 27(9). 9 27 2589-0042 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/61320 |
| publishDate | 2024 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Epidemiology of herpes simplex virus type 1 in the United States: Systematic review, meta-analyses, and meta-regressionsRwedah A., AgeebHarfouche, ManaleChemaitelly, HiamAbu-Raddad, Laith J.Health sciencesDiseaseThis study aimed to analytically describe the epidemiology of herpes simplex virus type 1 (HSV-1) infection in the United States through a systematic review and meta-analytics. We reviewed 159 publications, identifying 190 seroprevalence measures and 43 proportions of HSV-1 detection in genital herpes. The pooled mean HSV-1 seroprevalence was 38.0% (95% CI: 30.9–45.4) among general-population children and 63.5% (95% CI: 61.3–65.7) among general-population adults. Age explained 43% of the seroprevalence variation, with rates increasing progressively with age. Seroprevalence declined by 0.99-fold (95% CI: 0.99–0.99) per year. The pooled mean proportion of HSV-1 detection in genital herpes was 15.4% (95% CI: 10.8–20.6), increasing by 1.02-fold (95% CI: 1.00–1.04) per year. Recurrent genital herpes had a 0.17-fold (95% CI: 0.09–0.32) lower proportion of HSV-1 detection compared to first-episode cases. The epidemiology of HSV-1 is shifting, marked by a decline in oral acquisition during childhood and an increase in genital acquisition during adulthood.- Qatar Research, Development, and Innovation Council (NPRP 9-040-3-008). - University of Washington (ARG01-0524-230321). - Qatar National Research Fund - QNRF.Elsevier2024-11-19T11:15:49Z2024-09-20Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.isci.2024.110652Ageeb, R. A., Harfouche, M., Chemaitelly, H., & Abu-Raddad, L. J. (2024). Epidemiology of herpes simplex virus type 1 in the United States: Systematic review, meta-analyses, and meta-regressions. Iscience, 27(9).https://www.sciencedirect.com/science/article/pii/S2589004224018777http://hdl.handle.net/10576/613209272589-0042enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/613202024-11-19T19:07:31Z |
| spellingShingle | Epidemiology of herpes simplex virus type 1 in the United States: Systematic review, meta-analyses, and meta-regressions Rwedah A., Ageeb Health sciences Disease |
| status_str | publishedVersion |
| title | Epidemiology of herpes simplex virus type 1 in the United States: Systematic review, meta-analyses, and meta-regressions |
| title_full | Epidemiology of herpes simplex virus type 1 in the United States: Systematic review, meta-analyses, and meta-regressions |
| title_fullStr | Epidemiology of herpes simplex virus type 1 in the United States: Systematic review, meta-analyses, and meta-regressions |
| title_full_unstemmed | Epidemiology of herpes simplex virus type 1 in the United States: Systematic review, meta-analyses, and meta-regressions |
| title_short | Epidemiology of herpes simplex virus type 1 in the United States: Systematic review, meta-analyses, and meta-regressions |
| title_sort | Epidemiology of herpes simplex virus type 1 in the United States: Systematic review, meta-analyses, and meta-regressions |
| topic | Health sciences Disease |
| url | http://dx.doi.org/10.1016/j.isci.2024.110652 https://www.sciencedirect.com/science/article/pii/S2589004224018777 http://hdl.handle.net/10576/61320 |