Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women
Vitamin D deficiency has been linked to increased adiposity and decreased bone density. It is not known if vitamin D is linked to adiposity measures and bone mass in postmenopausal Qatar women. We investigated an association between serum vitamin D [25-hydroxyvitmain D (25(OH)D)] and adiposity measu...
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2021
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| Online Access: | http://dx.doi.org/10.1016/j.jsbmb.2021.105923 https://www.sciencedirect.com/science/article/pii/S0960076021001163 http://hdl.handle.net/10576/20594 |
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| _version_ | 1857415084351946752 |
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| author | Vijay, Ganji |
| author2 | Shi, Zumin Alshami, Hanadi Ajina, Sarah Albakri, Shayma Jasim, Zahra |
| author2_role | author author author author author |
| author_facet | Vijay, Ganji Shi, Zumin Alshami, Hanadi Ajina, Sarah Albakri, Shayma Jasim, Zahra |
| author_role | author |
| dc.creator.none.fl_str_mv | Vijay, Ganji Shi, Zumin Alshami, Hanadi Ajina, Sarah Albakri, Shayma Jasim, Zahra |
| dc.date.none.fl_str_mv | 2021-06-10T11:00:05Z 2021-09-30 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.jsbmb.2021.105923 Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women AU - Ganji, Vijay AU - Shi, Zumin AU - Alshami, Hanadi AU - Ajina, Sarah AU - Albakri, Shayma AU - Jasim, Zahra JO - The Journal of Steroid Biochemistry and Molecular Biology VL - 212 SP - 105923 PY - 2021 DA - 2021/09/01/ SN - 0960-0760 DO - https://doi.org/10.1016/j.jsbmb.2021.105923 UR - https://www.sciencedirect.com/science/article/pii/S0960076021001163 KW 09600760 https://www.sciencedirect.com/science/article/pii/S0960076021001163 http://hdl.handle.net/10576/20594 212 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | 25-hydroxyvitamin D Adiposity BMI Bone mass Post-menopausal women Qatar Biobank Vitamin D Waist conference |
| dc.title.none.fl_str_mv | Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Vitamin D deficiency has been linked to increased adiposity and decreased bone density. It is not known if vitamin D is linked to adiposity measures and bone mass in postmenopausal Qatar women. We investigated an association between serum vitamin D [25-hydroxyvitmain D (25(OH)D)] and adiposity measurements in postmenopausal women using Qatar Biobank data (n = 935). The post-menopausal status was self-reported by participants. Multivariate adjusted regression was applied to determine the association between serum 25(OH)D and body adiposity markers and bone mass. Serum 25(OH)D was significantly, inversely associated with body mass index (p < 0.0005), waist circumference (0.044), fat mass (p < 0.003), gynoid fat (p < 0.001), and android fat (p < 0.009). Serum 25(OH)D appeared to have an inverse ‘U’ association with several adiposity measures. Overall, body adiposity markers were the lowest in the 4th quartile serum 25(OH)D and significantly lower compared to the 1st quartile serum 25(OH)D. In multivariable adjusted analysis, no association was found between serum 25(OH)D concentration and bone mass when serum 25(OH)D was categorized. In a continuous variable analysis, the association between 25(OH)D and bone mass was significant, non-linear, inverse ‘U’. In conclusion, serum 25-hydroxyvitamin D was inversely associated with adiposity measures and non-linearly associated to bone mass in postmenopausal Qatari women. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_3eaac17c046b0b1cf9375ad7d0f38e43 |
| identifier_str_mv | Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women AU - Ganji, Vijay AU - Shi, Zumin AU - Alshami, Hanadi AU - Ajina, Sarah AU - Albakri, Shayma AU - Jasim, Zahra JO - The Journal of Steroid Biochemistry and Molecular Biology VL - 212 SP - 105923 PY - 2021 DA - 2021/09/01/ SN - 0960-0760 DO - https://doi.org/10.1016/j.jsbmb.2021.105923 UR - https://www.sciencedirect.com/science/article/pii/S0960076021001163 KW 09600760 212 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/20594 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal womenVijay, GanjiShi, ZuminAlshami, HanadiAjina, SarahAlbakri, ShaymaJasim, Zahra25-hydroxyvitamin DAdiposityBMIBone massPost-menopausal womenQatar BiobankVitamin DWaist conferenceVitamin D deficiency has been linked to increased adiposity and decreased bone density. It is not known if vitamin D is linked to adiposity measures and bone mass in postmenopausal Qatar women. We investigated an association between serum vitamin D [25-hydroxyvitmain D (25(OH)D)] and adiposity measurements in postmenopausal women using Qatar Biobank data (n = 935). The post-menopausal status was self-reported by participants. Multivariate adjusted regression was applied to determine the association between serum 25(OH)D and body adiposity markers and bone mass. Serum 25(OH)D was significantly, inversely associated with body mass index (p < 0.0005), waist circumference (0.044), fat mass (p < 0.003), gynoid fat (p < 0.001), and android fat (p < 0.009). Serum 25(OH)D appeared to have an inverse ‘U’ association with several adiposity measures. Overall, body adiposity markers were the lowest in the 4th quartile serum 25(OH)D and significantly lower compared to the 1st quartile serum 25(OH)D. In multivariable adjusted analysis, no association was found between serum 25(OH)D concentration and bone mass when serum 25(OH)D was categorized. In a continuous variable analysis, the association between 25(OH)D and bone mass was significant, non-linear, inverse ‘U’. In conclusion, serum 25-hydroxyvitamin D was inversely associated with adiposity measures and non-linearly associated to bone mass in postmenopausal Qatari women.Elsevier2021-06-10T11:00:05Z2021-09-30Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.jsbmb.2021.105923Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women AU - Ganji, Vijay AU - Shi, Zumin AU - Alshami, Hanadi AU - Ajina, Sarah AU - Albakri, Shayma AU - Jasim, Zahra JO - The Journal of Steroid Biochemistry and Molecular Biology VL - 212 SP - 105923 PY - 2021 DA - 2021/09/01/ SN - 0960-0760 DO - https://doi.org/10.1016/j.jsbmb.2021.105923 UR - https://www.sciencedirect.com/science/article/pii/S0960076021001163 KW09600760https://www.sciencedirect.com/science/article/pii/S0960076021001163http://hdl.handle.net/10576/20594212enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/205942024-07-23T11:23:42Z |
| spellingShingle | Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women Vijay, Ganji 25-hydroxyvitamin D Adiposity BMI Bone mass Post-menopausal women Qatar Biobank Vitamin D Waist conference |
| status_str | publishedVersion |
| title | Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women |
| title_full | Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women |
| title_fullStr | Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women |
| title_full_unstemmed | Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women |
| title_short | Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women |
| title_sort | Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women |
| topic | 25-hydroxyvitamin D Adiposity BMI Bone mass Post-menopausal women Qatar Biobank Vitamin D Waist conference |
| url | http://dx.doi.org/10.1016/j.jsbmb.2021.105923 https://www.sciencedirect.com/science/article/pii/S0960076021001163 http://hdl.handle.net/10576/20594 |