Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway
Compelling evidence has demonstrated that tumor bulk comprises distinctive subset of cells generally referred as cancer stem cells (CSCs) that has been proposed as a strong sustainer and promoter of tumorigenesis and therapeutic resistance. These distinguished properties of CSCs have raised interest...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , |
| التنسيق: | article |
| منشور في: |
2020
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.semcancer.2020.08.014 https://www.sciencedirect.com/science/article/pii/S1044579X2030184X?v=s5 http://hdl.handle.net/10576/16859 |
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| _version_ | 1857415086760525824 |
|---|---|
| author | Sabah, Akhtar |
| author2 | Hourani, Shireen Therachiyil, Lubna Al-Dhfyan, Abdullah Agouni, Abdelali Zeidan, Asad Uddin, Shahab Korashy, Hesham M. |
| author2_role | author author author author author author author |
| author_facet | Sabah, Akhtar Hourani, Shireen Therachiyil, Lubna Al-Dhfyan, Abdullah Agouni, Abdelali Zeidan, Asad Uddin, Shahab Korashy, Hesham M. |
| author_role | author |
| dc.creator.none.fl_str_mv | Sabah, Akhtar Hourani, Shireen Therachiyil, Lubna Al-Dhfyan, Abdullah Agouni, Abdelali Zeidan, Asad Uddin, Shahab Korashy, Hesham M. |
| dc.date.none.fl_str_mv | 2020-11-04T05:18:18Z 2020-08-30 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.semcancer.2020.08.014 Akhtar S, Hourani S, Therachiyil L, Al-Dhfyan A, Agouni A, Zeidan A, Uddin S, Korashy HM. Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway. Semin Cancer Biol. 2020 Aug 30:S1044-579X(20)30184-X. doi: 10.1016/j.semcancer.2020.08.014. Epub ahead of print. PMID: 32877761. 1044579X https://www.sciencedirect.com/science/article/pii/S1044579X2030184X?v=s5 http://hdl.handle.net/10576/16859 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cancer stem cells aryl hydrocarbon receptor epigenesis histone modification DNA methylation microRNAs molecular mechanisms CYP1A1 CYP1B1 |
| dc.title.none.fl_str_mv | Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Compelling evidence has demonstrated that tumor bulk comprises distinctive subset of cells generally referred as cancer stem cells (CSCs) that has been proposed as a strong sustainer and promoter of tumorigenesis and therapeutic resistance. These distinguished properties of CSCs have raised interest in understanding the molecular mechanisms that govern the maintenance of these cells. Numerous experimental and epidemiological studies have demonstrated that exposure to environmental toxins such as the polycyclic aromatic hydrocarbons (PAHs) is strongly involved in cancer initiation and progression. The PAH-induced carcinogenesis is shown to be mediated through the activation of a cytosolic receptor, aryl hydrocarbon receptor (AhR)/Cytochrome P4501A pathway, suggesting a possible direct link between AhR and CSCs. Several recent studies have investigated the role of AhR in CSCs self-renewal and maintenance, however the molecular mechanisms and particularly the epigenetic regulations of CSCs by AhR have not been reviewed before. In this review, we first summarize the crosstalk between AhR and cancer genetics, with particular emphasis on mechanisms relevant to CSCs such as Wnt/β-catenin pathway, Notch pathway, NF-κB pathway, PTEN-PI3K/Akt pathway and Drug Resistance-mediating pathways. The second part of this review discusses the recent advances and studies highlighting the epigenetic mechanisms mediated by the AhR pathway that control CSC gene expression, self-renewal, and chemoresistance in various human cancers. Furthermore, the review also sheds light on the importance of targeting the epigenetic pathways as a novel therapeutic approach against CSCs. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_40c4624527d4b9b47c2da2f7387cc366 |
| identifier_str_mv | Akhtar S, Hourani S, Therachiyil L, Al-Dhfyan A, Agouni A, Zeidan A, Uddin S, Korashy HM. Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway. Semin Cancer Biol. 2020 Aug 30:S1044-579X(20)30184-X. doi: 10.1016/j.semcancer.2020.08.014. Epub ahead of print. PMID: 32877761. 1044579X |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/16859 |
| publishDate | 2020 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor PathwaySabah, AkhtarHourani, ShireenTherachiyil, LubnaAl-Dhfyan, AbdullahAgouni, AbdelaliZeidan, AsadUddin, ShahabKorashy, Hesham M.Cancer stem cellsaryl hydrocarbon receptorepigenesishistone modificationDNA methylationmicroRNAsmolecular mechanismsCYP1A1CYP1B1Compelling evidence has demonstrated that tumor bulk comprises distinctive subset of cells generally referred as cancer stem cells (CSCs) that has been proposed as a strong sustainer and promoter of tumorigenesis and therapeutic resistance. These distinguished properties of CSCs have raised interest in understanding the molecular mechanisms that govern the maintenance of these cells. Numerous experimental and epidemiological studies have demonstrated that exposure to environmental toxins such as the polycyclic aromatic hydrocarbons (PAHs) is strongly involved in cancer initiation and progression. The PAH-induced carcinogenesis is shown to be mediated through the activation of a cytosolic receptor, aryl hydrocarbon receptor (AhR)/Cytochrome P4501A pathway, suggesting a possible direct link between AhR and CSCs. Several recent studies have investigated the role of AhR in CSCs self-renewal and maintenance, however the molecular mechanisms and particularly the epigenetic regulations of CSCs by AhR have not been reviewed before. In this review, we first summarize the crosstalk between AhR and cancer genetics, with particular emphasis on mechanisms relevant to CSCs such as Wnt/β-catenin pathway, Notch pathway, NF-κB pathway, PTEN-PI3K/Akt pathway and Drug Resistance-mediating pathways. The second part of this review discusses the recent advances and studies highlighting the epigenetic mechanisms mediated by the AhR pathway that control CSC gene expression, self-renewal, and chemoresistance in various human cancers. Furthermore, the review also sheds light on the importance of targeting the epigenetic pathways as a novel therapeutic approach against CSCs.Elsevier2020-11-04T05:18:18Z2020-08-30Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.semcancer.2020.08.014Akhtar S, Hourani S, Therachiyil L, Al-Dhfyan A, Agouni A, Zeidan A, Uddin S, Korashy HM. Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway. Semin Cancer Biol. 2020 Aug 30:S1044-579X(20)30184-X. doi: 10.1016/j.semcancer.2020.08.014. Epub ahead of print. PMID: 32877761.1044579Xhttps://www.sciencedirect.com/science/article/pii/S1044579X2030184X?v=s5http://hdl.handle.net/10576/16859enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/168592024-07-23T11:23:07Z |
| spellingShingle | Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway Sabah, Akhtar Cancer stem cells aryl hydrocarbon receptor epigenesis histone modification DNA methylation microRNAs molecular mechanisms CYP1A1 CYP1B1 |
| status_str | publishedVersion |
| title | Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway |
| title_full | Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway |
| title_fullStr | Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway |
| title_full_unstemmed | Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway |
| title_short | Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway |
| title_sort | Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway |
| topic | Cancer stem cells aryl hydrocarbon receptor epigenesis histone modification DNA methylation microRNAs molecular mechanisms CYP1A1 CYP1B1 |
| url | http://dx.doi.org/10.1016/j.semcancer.2020.08.014 https://www.sciencedirect.com/science/article/pii/S1044579X2030184X?v=s5 http://hdl.handle.net/10576/16859 |