Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region
Acute gastroenteritis is the cause of considerable mortality and morbidity worldwide, particularly among children under five years in underdeveloped countries. Most acute gastroenteritis (AGE) cases are attributed to viral etiologies, including rotavirus, norovirus, adenovirus, astrovirus, and sapov...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2022
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.jiph.2022.09.001 https://www.sciencedirect.com/science/article/pii/S1876034122002374 http://hdl.handle.net/10576/44634 |
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| _version_ | 1857415084378161152 |
|---|---|
| author | Israa, Elbashir |
| author2 | Aldoos, Noor F. Mathew, Shilu Al Thani, Asmaa A. Emara, Mohamed M. Yassine, Hadi M. |
| author2_role | author author author author author |
| author_facet | Israa, Elbashir Aldoos, Noor F. Mathew, Shilu Al Thani, Asmaa A. Emara, Mohamed M. Yassine, Hadi M. |
| author_role | author |
| dc.creator.none.fl_str_mv | Israa, Elbashir Aldoos, Noor F. Mathew, Shilu Al Thani, Asmaa A. Emara, Mohamed M. Yassine, Hadi M. |
| dc.date.none.fl_str_mv | 2022-11-30 2023-06-21T05:44:03Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.jiph.2022.09.001 18760341 https://www.sciencedirect.com/science/article/pii/S1876034122002374 http://hdl.handle.net/10576/44634 1193-1211 11 15 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Acute gastroenteritis Rotavirus Norovirus Adenovirus Astrovirus Sapovirus Phylogenetic analysis Rotavirus vaccine Middle East And North Africa |
| dc.title.none.fl_str_mv | Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Acute gastroenteritis is the cause of considerable mortality and morbidity worldwide, particularly among children under five years in underdeveloped countries. Most acute gastroenteritis (AGE) cases are attributed to viral etiologies, including rotavirus, norovirus, adenovirus, astrovirus, and sapovirus. This paper aimed to determine the prevalence rate of different viral etiologies of AGE in the Middle East and North Africa (MENA) region. Moreover, this paper explored rotavirus phylogenetic relatedness, compared VP7 and VP4 antigenic regions of rotavirus with vaccine strains, and explored the availability of vaccines in the MENA region. The literature search identified 160 studies from 18 countries from 1980 to 2019. The overall prevalence of rotavirus, norovirus, adenovirus, astrovirus, and sapovirus were 29.8 %, 13.9 %, 6.3 %, 3.5 %, and 3.2 % of tested samples, respectively. The most common rotavirus genotype combinations in the MENA region were G1P[8], G9P[9], and G2P[4], whereas GII.4 was the predominant norovirus genotype all of which were reported in almost all the studies with genotyping data. The comparison of VP7 and VP4 between circulating rotavirus in the MENA region and vaccine strains has revealed discrete divergent regions, including the neutralizing epitopes. Rotavirus vaccine was introduced to most of the countries of the MENA region; however, only a few studies have assessed the effectiveness of vaccine introduction. This paper provides a comprehensive update on the prevalence of the different viral agents of AGE in the MENA region. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_41b25a85a78c6a67f93f31a1ee3b805c |
| identifier_str_mv | 18760341 1193-1211 11 15 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/44634 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) regionIsraa, ElbashirAldoos, Noor F.Mathew, ShiluAl Thani, Asmaa A.Emara, Mohamed M.Yassine, Hadi M.Acute gastroenteritisRotavirusNorovirusAdenovirusAstrovirusSapovirusPhylogenetic analysisRotavirus vaccineMiddle EastAnd North AfricaAcute gastroenteritis is the cause of considerable mortality and morbidity worldwide, particularly among children under five years in underdeveloped countries. Most acute gastroenteritis (AGE) cases are attributed to viral etiologies, including rotavirus, norovirus, adenovirus, astrovirus, and sapovirus. This paper aimed to determine the prevalence rate of different viral etiologies of AGE in the Middle East and North Africa (MENA) region. Moreover, this paper explored rotavirus phylogenetic relatedness, compared VP7 and VP4 antigenic regions of rotavirus with vaccine strains, and explored the availability of vaccines in the MENA region. The literature search identified 160 studies from 18 countries from 1980 to 2019. The overall prevalence of rotavirus, norovirus, adenovirus, astrovirus, and sapovirus were 29.8 %, 13.9 %, 6.3 %, 3.5 %, and 3.2 % of tested samples, respectively. The most common rotavirus genotype combinations in the MENA region were G1P[8], G9P[9], and G2P[4], whereas GII.4 was the predominant norovirus genotype all of which were reported in almost all the studies with genotyping data. The comparison of VP7 and VP4 between circulating rotavirus in the MENA region and vaccine strains has revealed discrete divergent regions, including the neutralizing epitopes. Rotavirus vaccine was introduced to most of the countries of the MENA region; however, only a few studies have assessed the effectiveness of vaccine introduction. This paper provides a comprehensive update on the prevalence of the different viral agents of AGE in the MENA region.Open Access funding provided by the Qatar National Library (QNL).Elsevier2023-06-21T05:44:03Z2022-11-30Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.jiph.2022.09.00118760341https://www.sciencedirect.com/science/article/pii/S1876034122002374http://hdl.handle.net/10576/446341193-12111115enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/446342024-07-23T13:53:40Z |
| spellingShingle | Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region Israa, Elbashir Acute gastroenteritis Rotavirus Norovirus Adenovirus Astrovirus Sapovirus Phylogenetic analysis Rotavirus vaccine Middle East And North Africa |
| status_str | publishedVersion |
| title | Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region |
| title_full | Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region |
| title_fullStr | Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region |
| title_full_unstemmed | Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region |
| title_short | Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region |
| title_sort | Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region |
| topic | Acute gastroenteritis Rotavirus Norovirus Adenovirus Astrovirus Sapovirus Phylogenetic analysis Rotavirus vaccine Middle East And North Africa |
| url | http://dx.doi.org/10.1016/j.jiph.2022.09.001 https://www.sciencedirect.com/science/article/pii/S1876034122002374 http://hdl.handle.net/10576/44634 |