2D magnesium phosphate resorbable coating to enhance cell adhesion on titanium surfaces
Titanium and its alloys are essential metals for orthopedic implant manufacturing due to their exceptional mechanical properties and biocompatibility, used extensively for treating various orthopedic conditions. However, Titanium (Ti) implants have a disadvantage due to lack of bioactivity, potentia...
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2024
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| Online Access: | http://dx.doi.org/10.1016/j.matchemphys.2024.129114 https://www.sciencedirect.com/science/article/pii/S0254058424002396 http://hdl.handle.net/10576/55239 |
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| _version_ | 1857415086587510784 |
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| author | Amir, Elhadad |
| author2 | Mezour, Mohamed A. Abu Nada, Lina Shurbaji, Samar Mansour, Alaa Smith, Sophia Moussa, Hanan lee, Lisa Pérez-Soriano, Eva M. Murshed, Monzur Chromik, Richard Tamimi, Faleh |
| author2_role | author author author author author author author author author author author |
| author_facet | Amir, Elhadad Mezour, Mohamed A. Abu Nada, Lina Shurbaji, Samar Mansour, Alaa Smith, Sophia Moussa, Hanan lee, Lisa Pérez-Soriano, Eva M. Murshed, Monzur Chromik, Richard Tamimi, Faleh |
| author_role | author |
| dc.creator.none.fl_str_mv | Amir, Elhadad Mezour, Mohamed A. Abu Nada, Lina Shurbaji, Samar Mansour, Alaa Smith, Sophia Moussa, Hanan lee, Lisa Pérez-Soriano, Eva M. Murshed, Monzur Chromik, Richard Tamimi, Faleh |
| dc.date.none.fl_str_mv | 2024-05-21T10:18:17Z 2024-02-27 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.matchemphys.2024.129114 0254-0584 https://www.sciencedirect.com/science/article/pii/S0254058424002396 http://hdl.handle.net/10576/55239 316 1879-3312 |
| dc.language.none.fl_str_mv | en |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Titanium Bioactivity Magnesium phosphate Coatings Protein adsorption |
| dc.title.none.fl_str_mv | 2D magnesium phosphate resorbable coating to enhance cell adhesion on titanium surfaces |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Titanium and its alloys are essential metals for orthopedic implant manufacturing due to their exceptional mechanical properties and biocompatibility, used extensively for treating various orthopedic conditions. However, Titanium (Ti) implants have a disadvantage due to lack of bioactivity, potentially affecting osseointegration and osteoconductive capabilities, and may take several months to integrate with bone tissue. In this work, we prepared a layer of 2D magnesium phosphate (MgPi) coating on the surface of titanium surfaces via the spin-coating technique. Various techniques were used to study the phase composition of the coatings, including FTIR, Raman spectroscopy, NMR, and XRD analysis. Morphology and chemical analysis were performed using Atomic force microscopy and SEM/EDX. Nano-scratch test and water contact angle measurements were used to measure adhesion strength and wettability. In addition, in vitro cell assays were used to assess cell adhesion and viability to determine how the MC3T3-E1 osteoblast-like cells reacted to the different treated Ti substrates. AFM results showed that the surface roughness became lower after coatings. MgPi-coated samples showed higher hydrophilicity, protein adsorption, and cell viability than uncoated samples. The nano-scratch test showed that the MgPi coating showed better adherence to chemically and thermally treated samples compared to untreated samples. The deposited MgPi coating has good adhesion to the Ti-substrates. Most significantly, compared to uncoated control (Ti) (p < 0.005) and chemically treated coated samples CT-MgPi (p < 0.005), MC3T3-E1 cell proliferation was significantly increased on thermochemical coated surfaces. These findings point to resorbable two-dimensional MgPi coatings as a potential candidate for promoting Ti implant osseointegration. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_42833272aafd86cf598024f7884dd522 |
| identifier_str_mv | 0254-0584 316 1879-3312 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/55239 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | 2D magnesium phosphate resorbable coating to enhance cell adhesion on titanium surfacesAmir, ElhadadMezour, Mohamed A.Abu Nada, LinaShurbaji, SamarMansour, AlaaSmith, SophiaMoussa, Hananlee, LisaPérez-Soriano, Eva M.Murshed, MonzurChromik, RichardTamimi, FalehTitaniumBioactivityMagnesium phosphateCoatingsProtein adsorptionTitanium and its alloys are essential metals for orthopedic implant manufacturing due to their exceptional mechanical properties and biocompatibility, used extensively for treating various orthopedic conditions. However, Titanium (Ti) implants have a disadvantage due to lack of bioactivity, potentially affecting osseointegration and osteoconductive capabilities, and may take several months to integrate with bone tissue. In this work, we prepared a layer of 2D magnesium phosphate (MgPi) coating on the surface of titanium surfaces via the spin-coating technique. Various techniques were used to study the phase composition of the coatings, including FTIR, Raman spectroscopy, NMR, and XRD analysis. Morphology and chemical analysis were performed using Atomic force microscopy and SEM/EDX. Nano-scratch test and water contact angle measurements were used to measure adhesion strength and wettability. In addition, in vitro cell assays were used to assess cell adhesion and viability to determine how the MC3T3-E1 osteoblast-like cells reacted to the different treated Ti substrates. AFM results showed that the surface roughness became lower after coatings. MgPi-coated samples showed higher hydrophilicity, protein adsorption, and cell viability than uncoated samples. The nano-scratch test showed that the MgPi coating showed better adherence to chemically and thermally treated samples compared to untreated samples. The deposited MgPi coating has good adhesion to the Ti-substrates. Most significantly, compared to uncoated control (Ti) (p < 0.005) and chemically treated coated samples CT-MgPi (p < 0.005), MC3T3-E1 cell proliferation was significantly increased on thermochemical coated surfaces. These findings point to resorbable two-dimensional MgPi coatings as a potential candidate for promoting Ti implant osseointegration.The authors would like to acknowledge Le Réseau de recherche en santé buccodentaire et osseuse (RSBO) , Canada Research Chairs (CRC) , the Natural Sciences and Engineering Research Council of Canada (NSERC) for their financial support, Qatar University , and the Libyan ministry of education and scientific research .2024-05-21T10:18:17Z2024-02-27Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.matchemphys.2024.1291140254-0584https://www.sciencedirect.com/science/article/pii/S0254058424002396http://hdl.handle.net/10576/552393161879-3312enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/552392024-07-23T10:58:45Z |
| spellingShingle | 2D magnesium phosphate resorbable coating to enhance cell adhesion on titanium surfaces Amir, Elhadad Titanium Bioactivity Magnesium phosphate Coatings Protein adsorption |
| status_str | publishedVersion |
| title | 2D magnesium phosphate resorbable coating to enhance cell adhesion on titanium surfaces |
| title_full | 2D magnesium phosphate resorbable coating to enhance cell adhesion on titanium surfaces |
| title_fullStr | 2D magnesium phosphate resorbable coating to enhance cell adhesion on titanium surfaces |
| title_full_unstemmed | 2D magnesium phosphate resorbable coating to enhance cell adhesion on titanium surfaces |
| title_short | 2D magnesium phosphate resorbable coating to enhance cell adhesion on titanium surfaces |
| title_sort | 2D magnesium phosphate resorbable coating to enhance cell adhesion on titanium surfaces |
| topic | Titanium Bioactivity Magnesium phosphate Coatings Protein adsorption |
| url | http://dx.doi.org/10.1016/j.matchemphys.2024.129114 https://www.sciencedirect.com/science/article/pii/S0254058424002396 http://hdl.handle.net/10576/55239 |