Assessment of the possible synergetic effect of micro-osteoperforations and injectable platelet-rich fibrin on the rate of maxillary canine retraction of young adults: A split-mouth randomized controlled clinical trial
IntroductionThis study primarily aimed to evaluate the combined impacts of micro-osteoperforations (MOPs) and injectable platelet-rich fibrin (I-PRF) on the rate of maxillary canine retraction. Additionally, it explored the side effects of the related rotation, tipping, and vertical movements. Mater...
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| التنسيق: | article |
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2025
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| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.ortho.2025.101006 https://www.sciencedirect.com/science/article/pii/S1761722725000415 http://hdl.handle.net/10576/65153 |
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| _version_ | 1857415087321513984 |
|---|---|
| author | Al-Haifi, Hend Abul karem Abdullah |
| author2 | Ishaq, Ramy Abdulrahman Ali Al-Jawfi, Khaled Ahmed Mohammed Al-Ashtal, Amin Mohsen Saleh Alhammadi, Maged S. Almashraqi, Abeer A. |
| author2_role | author author author author author |
| author_facet | Al-Haifi, Hend Abul karem Abdullah Ishaq, Ramy Abdulrahman Ali Al-Jawfi, Khaled Ahmed Mohammed Al-Ashtal, Amin Mohsen Saleh Alhammadi, Maged S. Almashraqi, Abeer A. |
| author_role | author |
| dc.creator.none.fl_str_mv | Al-Haifi, Hend Abul karem Abdullah Ishaq, Ramy Abdulrahman Ali Al-Jawfi, Khaled Ahmed Mohammed Al-Ashtal, Amin Mohsen Saleh Alhammadi, Maged S. Almashraqi, Abeer A. |
| dc.date.none.fl_str_mv | 2025-05-26T06:20:31Z 2025-09-30 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.ortho.2025.101006 17617227 https://www.sciencedirect.com/science/article/pii/S1761722725000415 http://hdl.handle.net/10576/65153 3 23 1879-680X |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Accelerated orthodontics Micro-osteoperforations Platelet-rich fibrin Canine retraction Split-mouth |
| dc.title.none.fl_str_mv | Assessment of the possible synergetic effect of micro-osteoperforations and injectable platelet-rich fibrin on the rate of maxillary canine retraction of young adults: A split-mouth randomized controlled clinical trial |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | IntroductionThis study primarily aimed to evaluate the combined impacts of micro-osteoperforations (MOPs) and injectable platelet-rich fibrin (I-PRF) on the rate of maxillary canine retraction. Additionally, it explored the side effects of the related rotation, tipping, and vertical movements. Material and methodsAll patients who met the eligibility criteria (Class II Division 1 malocclusion, mild to moderate crowding, bilateral Class II canines, good oral hygiene, and requiring therapeutic extraction of the maxillary first premolars) between April and December 2021 were recruited. This included 25 young adult orthodontic patients (19 females and 6 males). One side of the maxillary arch was randomly chosen to receive MOPs combined with I-PRF, forming the experimental group. In contrast, the other side received only MOPs, serving as the control group. The maxillary canine retraction rate was measured every 4 weeks over a 24-week follow-up period (T0 [before canine retraction] – T6 [after 24-week]). Additionally, canine rotation, intrusion/extrusion, and tipping were evaluated using cone-beam computed tomography (CBCT) before and after retraction at two-time points (T0 and T6). The independent t-test was used to compare the experimental and control groups. Comparisons between stages from T0 to T6 were completed using the t-test for paired samples and repeated measure analysis of variance (ANOVA). The P-values were adjusted using Bonferroni correction. ResultsThis study analysed 25 young adult patients (19 females and 6 males; average age 20.47±4.1 years). The rate of maxillary canine retraction was significantly different between the experimental and control sides, with an overall rate of 1.25±0.28 and 0.75±0.1mm/month (P=0.04, q=0.006), respectively. This significantly faster rate occurred at T1–T2 and T4–T5 time points on the experimental compared to the control side. Canine tipping was also greater in the experimental side, at 3.89±0.19° than in the control side, at 1.80±0.12° (P=0.03, q=0.005). No significant differences were found in maxillary canine rotation, extrusion, or intrusion between the two sides. ConclusionThe combination of MOPs and I-PRF demonstrated a synergistic effect, significantly accelerating orthodontic tooth movement during maxillary canine retraction within 6 months of a clinical evaluation, but also with a significant tipping movement. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_469e8bd8b95d58a72340f0e484363b41 |
| identifier_str_mv | 17617227 3 23 1879-680X |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/65153 |
| publishDate | 2025 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Assessment of the possible synergetic effect of micro-osteoperforations and injectable platelet-rich fibrin on the rate of maxillary canine retraction of young adults: A split-mouth randomized controlled clinical trialAl-Haifi, Hend Abul karem AbdullahIshaq, Ramy Abdulrahman AliAl-Jawfi, Khaled Ahmed MohammedAl-Ashtal, Amin Mohsen SalehAlhammadi, Maged S.Almashraqi, Abeer A.Accelerated orthodonticsMicro-osteoperforationsPlatelet-rich fibrinCanine retractionSplit-mouthIntroductionThis study primarily aimed to evaluate the combined impacts of micro-osteoperforations (MOPs) and injectable platelet-rich fibrin (I-PRF) on the rate of maxillary canine retraction. Additionally, it explored the side effects of the related rotation, tipping, and vertical movements. Material and methodsAll patients who met the eligibility criteria (Class II Division 1 malocclusion, mild to moderate crowding, bilateral Class II canines, good oral hygiene, and requiring therapeutic extraction of the maxillary first premolars) between April and December 2021 were recruited. This included 25 young adult orthodontic patients (19 females and 6 males). One side of the maxillary arch was randomly chosen to receive MOPs combined with I-PRF, forming the experimental group. In contrast, the other side received only MOPs, serving as the control group. The maxillary canine retraction rate was measured every 4 weeks over a 24-week follow-up period (T0 [before canine retraction] – T6 [after 24-week]). Additionally, canine rotation, intrusion/extrusion, and tipping were evaluated using cone-beam computed tomography (CBCT) before and after retraction at two-time points (T0 and T6). The independent t-test was used to compare the experimental and control groups. Comparisons between stages from T0 to T6 were completed using the t-test for paired samples and repeated measure analysis of variance (ANOVA). The P-values were adjusted using Bonferroni correction. ResultsThis study analysed 25 young adult patients (19 females and 6 males; average age 20.47±4.1 years). The rate of maxillary canine retraction was significantly different between the experimental and control sides, with an overall rate of 1.25±0.28 and 0.75±0.1mm/month (P=0.04, q=0.006), respectively. This significantly faster rate occurred at T1–T2 and T4–T5 time points on the experimental compared to the control side. Canine tipping was also greater in the experimental side, at 3.89±0.19° than in the control side, at 1.80±0.12° (P=0.03, q=0.005). No significant differences were found in maxillary canine rotation, extrusion, or intrusion between the two sides. ConclusionThe combination of MOPs and I-PRF demonstrated a synergistic effect, significantly accelerating orthodontic tooth movement during maxillary canine retraction within 6 months of a clinical evaluation, but also with a significant tipping movement.This project was partially funded by the University of Science and Technology, Sanaá, Yemen.Elsevier2025-05-26T06:20:31Z2025-09-30Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.ortho.2025.10100617617227https://www.sciencedirect.com/science/article/pii/S1761722725000415http://hdl.handle.net/10576/651533231879-680Xenhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/651532025-05-26T19:05:53Z |
| spellingShingle | Assessment of the possible synergetic effect of micro-osteoperforations and injectable platelet-rich fibrin on the rate of maxillary canine retraction of young adults: A split-mouth randomized controlled clinical trial Al-Haifi, Hend Abul karem Abdullah Accelerated orthodontics Micro-osteoperforations Platelet-rich fibrin Canine retraction Split-mouth |
| status_str | publishedVersion |
| title | Assessment of the possible synergetic effect of micro-osteoperforations and injectable platelet-rich fibrin on the rate of maxillary canine retraction of young adults: A split-mouth randomized controlled clinical trial |
| title_full | Assessment of the possible synergetic effect of micro-osteoperforations and injectable platelet-rich fibrin on the rate of maxillary canine retraction of young adults: A split-mouth randomized controlled clinical trial |
| title_fullStr | Assessment of the possible synergetic effect of micro-osteoperforations and injectable platelet-rich fibrin on the rate of maxillary canine retraction of young adults: A split-mouth randomized controlled clinical trial |
| title_full_unstemmed | Assessment of the possible synergetic effect of micro-osteoperforations and injectable platelet-rich fibrin on the rate of maxillary canine retraction of young adults: A split-mouth randomized controlled clinical trial |
| title_short | Assessment of the possible synergetic effect of micro-osteoperforations and injectable platelet-rich fibrin on the rate of maxillary canine retraction of young adults: A split-mouth randomized controlled clinical trial |
| title_sort | Assessment of the possible synergetic effect of micro-osteoperforations and injectable platelet-rich fibrin on the rate of maxillary canine retraction of young adults: A split-mouth randomized controlled clinical trial |
| topic | Accelerated orthodontics Micro-osteoperforations Platelet-rich fibrin Canine retraction Split-mouth |
| url | http://dx.doi.org/10.1016/j.ortho.2025.101006 https://www.sciencedirect.com/science/article/pii/S1761722725000415 http://hdl.handle.net/10576/65153 |