Regioselective domino C–C/C–O arylation of 1,2,3-triiodobenzenes and 1,3-diketones: Synthesis and in silico evaluation of 7-iodobenzo[b]furan as potential ALK inhibitors

Regioselective domino C–C/C–O arylation of 1,2,3-triiodobenzenes and 1,3-diketones: Synthesis and in silico evaluation of 7-iodobenzo[b]furan as potential ALK inhibitors

We report a simple, direct, and regioselective protocol for the synthesis of 2,3-disubstituted 7-iodobenzo[b]furans via domino double CC/CO arylations of 1,2,3-triiodobenzene and 1,3-dicarbonyl compounds. Remarkably, the C-arylation occurred exclusively at the terminal positions, which are the most...

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Bibliographic Details
Main Author: Raed M., Al-Zoubi (author)
Other Authors: Al-Jammal, Walid K. (author), Shkoor, Mohanad (author), Bani-Yaseen, Abdulilah D. (author), Khan, Abbas (author), Agouni, Abdelali (author), McDonald, Robert (author)
Format: article
Published: 2025
Subjects:
Benzofuran
Iodination
Arylation
C-C coupling
C-O coupling
Substituent effect
Regioselectivity
Online Access:http://dx.doi.org/10.1016/j.jorganchem.2025.123526
https://www.sciencedirect.com/science/article/pii/S0022328X25000208
http://hdl.handle.net/10576/64075
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