Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac
The solvent effects on the photochemical conversion rate of the photosensitizing drug diclofenac (DCF) were investigated using steady-state fluorescence spectroscopy. The spectral information obtained for the photochemical reaction of DCF in a set of neat solvents demonstrates that the photoconversi...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
2023
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.heliyon.2023.e20767 https://www.sciencedirect.com/science/article/pii/S2405844023079756 http://hdl.handle.net/10576/51013 |
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| _version_ | 1857415084961169408 |
|---|---|
| author | Abdulilah Dawoud, Bani-Yaseen |
| author2 | Al-Zoubi, Raed M. Shkoor, Mohanad |
| author2_role | author author |
| author_facet | Abdulilah Dawoud, Bani-Yaseen Al-Zoubi, Raed M. Shkoor, Mohanad |
| author_role | author |
| dc.creator.none.fl_str_mv | Abdulilah Dawoud, Bani-Yaseen Al-Zoubi, Raed M. Shkoor, Mohanad |
| dc.date.none.fl_str_mv | 2023-11-30 2024-01-22T06:15:05Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.heliyon.2023.e20767 Bani-Yaseen, A. D., Al-Zoubi, R. M., & Shkoor, M. (2023). Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac. Heliyon, 9(11). 24058440 https://www.sciencedirect.com/science/article/pii/S2405844023079756 http://hdl.handle.net/10576/51013 11 9 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Diclofenac Photoconversion Fluorescence Solvent effects Solvatochromic models |
| dc.title.none.fl_str_mv | Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The solvent effects on the photochemical conversion rate of the photosensitizing drug diclofenac (DCF) were investigated using steady-state fluorescence spectroscopy. The spectral information obtained for the photochemical reaction of DCF in a set of neat solvents demonstrates that the photoconversion reaction rate of DCF is not only medium polarity dependent but also hydrogen-bonding dependent. The solvent effects were qualitatively and quantitatively assessed employing various solvatochromic models, including multi-parameter linear regression analysis (MLRA). Interestingly, the MLRA results (R = 0.99) revealed that the photoconversion rate increases with increasing solvent polarizability (π*) and H-bond donor capability (α), whereas the rate decreases with increasing hydrogen-bond acceptor capability (β). However, predominant effect of the solvent acidity compared to basicity and polarizability was observed. A hypothesis rationalizing the effects of H-bonding and medium polarity on DCF photoconversion reaction is presented and discussed. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_529e1d24e4da8569ad3afb2b5b9294fc |
| identifier_str_mv | Bani-Yaseen, A. D., Al-Zoubi, R. M., & Shkoor, M. (2023). Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac. Heliyon, 9(11). 24058440 11 9 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/51013 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenacAbdulilah Dawoud, Bani-YaseenAl-Zoubi, Raed M.Shkoor, MohanadDiclofenacPhotoconversionFluorescenceSolvent effectsSolvatochromic modelsThe solvent effects on the photochemical conversion rate of the photosensitizing drug diclofenac (DCF) were investigated using steady-state fluorescence spectroscopy. The spectral information obtained for the photochemical reaction of DCF in a set of neat solvents demonstrates that the photoconversion reaction rate of DCF is not only medium polarity dependent but also hydrogen-bonding dependent. The solvent effects were qualitatively and quantitatively assessed employing various solvatochromic models, including multi-parameter linear regression analysis (MLRA). Interestingly, the MLRA results (R = 0.99) revealed that the photoconversion rate increases with increasing solvent polarizability (π*) and H-bond donor capability (α), whereas the rate decreases with increasing hydrogen-bond acceptor capability (β). However, predominant effect of the solvent acidity compared to basicity and polarizability was observed. A hypothesis rationalizing the effects of H-bonding and medium polarity on DCF photoconversion reaction is presented and discussed.Partial support from Qatar University is acknowledged. Open Access funding provided by the Qatar National Library.Elsevier2024-01-22T06:15:05Z2023-11-30Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.heliyon.2023.e20767Bani-Yaseen, A. D., Al-Zoubi, R. M., & Shkoor, M. (2023). Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac. Heliyon, 9(11).24058440https://www.sciencedirect.com/science/article/pii/S2405844023079756http://hdl.handle.net/10576/51013119enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/510132024-07-23T15:52:31Z |
| spellingShingle | Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac Abdulilah Dawoud, Bani-Yaseen Diclofenac Photoconversion Fluorescence Solvent effects Solvatochromic models |
| status_str | publishedVersion |
| title | Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac |
| title_full | Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac |
| title_fullStr | Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac |
| title_full_unstemmed | Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac |
| title_short | Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac |
| title_sort | Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac |
| topic | Diclofenac Photoconversion Fluorescence Solvent effects Solvatochromic models |
| url | http://dx.doi.org/10.1016/j.heliyon.2023.e20767 https://www.sciencedirect.com/science/article/pii/S2405844023079756 http://hdl.handle.net/10576/51013 |