Beyond nutrition: The emerging therapeutic potential landscape of breast milk-derived extracellular vesicles
Breastfeeding is widely recognized for its essential nutritional benefits and broader biological impacts. Beyond providing infants with a balanced mix of vitamins, proteins, and fats critical for growth and development, breast milk contains bioactive extracellular vesicles (BMEVs). These membrane-bo...
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2025
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| Online Access: | http://dx.doi.org/10.1016/j.nutres.2025.01.006 https://www.sciencedirect.com/science/article/pii/S0271531725000144 http://hdl.handle.net/10576/64177 |
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| _version_ | 1857415083634720768 |
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| author | Hend, Al-Jaber |
| author2 | Bacha, Rim Al-Mannai, Wafaa A. Al-Mansoori, Layla |
| author2_role | author author author |
| author_facet | Hend, Al-Jaber Bacha, Rim Al-Mannai, Wafaa A. Al-Mansoori, Layla |
| author_role | author |
| dc.creator.none.fl_str_mv | Hend, Al-Jaber Bacha, Rim Al-Mannai, Wafaa A. Al-Mansoori, Layla |
| dc.date.none.fl_str_mv | 2025-04-13T10:16:42Z 2025-03 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.nutres.2025.01.006 Al-Jaber, H., Bacha, R., Al-Mannai, W. A., & Al-Mansoori, L. (2025). Beyond Nutrition: The Emerging Therapeutic Potential Landscape of Breast Milk-Derived Extracellular Vesicles. Nutrition Research. 0271-5317 https://www.sciencedirect.com/science/article/pii/S0271531725000144 http://hdl.handle.net/10576/64177 135 1879-0739 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Breast milk Therapy Exosomes Extracellular vesicles Infant health |
| dc.title.none.fl_str_mv | Beyond nutrition: The emerging therapeutic potential landscape of breast milk-derived extracellular vesicles |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Breastfeeding is widely recognized for its essential nutritional benefits and broader biological impacts. Beyond providing infants with a balanced mix of vitamins, proteins, and fats critical for growth and development, breast milk contains bioactive extracellular vesicles (BMEVs). These membrane-bound particles, rich in proteins, lipids, and nucleic acids, play a pivotal role in immune modulation, intercellular communication, and the overall development of the infant's immune system. This review explores the emerging therapeutic potential of BMEVs, highlighting their capacity to modulate recipient cell functions, influence immune responses, and contribute to overall infant health. Preclinical evidence suggests that these vesicles can prevent and manage conditions such as necrotizing enterocolitis, allergies, and viral infections, which are common in early childhood. Furthermore, BMEVs offer promise as vehicles for targeted drug delivery, enhancing the efficacy of therapeutic interventions. Despite the growing body of evidence, challenges such as the need for standardized isolation methods, characterization techniques, and larger-scale clinical studies persist, hindering the translation of this research into clinical practice. This review addresses these challenges and discusses future directions, emphasizing the need for comprehensive mechanistic studies to fully realize the potential of BMEVs as novel therapeutic agents and biomarkers of health. Ultimately, these vesicles represent a promising frontier in maternal and child health, with potential applications extending far beyond traditional nutrition. By harnessing their unique properties, BMEVs could revolutionize infant care, offering new strategies for disease prevention and innovative therapeutic interventions that enhance infant health outcomes. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_52e997dea70bbe78179d083ddf8e45c2 |
| identifier_str_mv | Al-Jaber, H., Bacha, R., Al-Mannai, W. A., & Al-Mansoori, L. (2025). Beyond Nutrition: The Emerging Therapeutic Potential Landscape of Breast Milk-Derived Extracellular Vesicles. Nutrition Research. 0271-5317 135 1879-0739 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/64177 |
| publishDate | 2025 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Beyond nutrition: The emerging therapeutic potential landscape of breast milk-derived extracellular vesiclesHend, Al-JaberBacha, RimAl-Mannai, Wafaa A.Al-Mansoori, LaylaBreast milkTherapyExosomesExtracellular vesiclesInfant healthBreastfeeding is widely recognized for its essential nutritional benefits and broader biological impacts. Beyond providing infants with a balanced mix of vitamins, proteins, and fats critical for growth and development, breast milk contains bioactive extracellular vesicles (BMEVs). These membrane-bound particles, rich in proteins, lipids, and nucleic acids, play a pivotal role in immune modulation, intercellular communication, and the overall development of the infant's immune system. This review explores the emerging therapeutic potential of BMEVs, highlighting their capacity to modulate recipient cell functions, influence immune responses, and contribute to overall infant health. Preclinical evidence suggests that these vesicles can prevent and manage conditions such as necrotizing enterocolitis, allergies, and viral infections, which are common in early childhood. Furthermore, BMEVs offer promise as vehicles for targeted drug delivery, enhancing the efficacy of therapeutic interventions. Despite the growing body of evidence, challenges such as the need for standardized isolation methods, characterization techniques, and larger-scale clinical studies persist, hindering the translation of this research into clinical practice. This review addresses these challenges and discusses future directions, emphasizing the need for comprehensive mechanistic studies to fully realize the potential of BMEVs as novel therapeutic agents and biomarkers of health. Ultimately, these vesicles represent a promising frontier in maternal and child health, with potential applications extending far beyond traditional nutrition. By harnessing their unique properties, BMEVs could revolutionize infant care, offering new strategies for disease prevention and innovative therapeutic interventions that enhance infant health outcomes.Elsevier2025-04-13T10:16:42Z2025-03Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.nutres.2025.01.006Al-Jaber, H., Bacha, R., Al-Mannai, W. A., & Al-Mansoori, L. (2025). Beyond Nutrition: The Emerging Therapeutic Potential Landscape of Breast Milk-Derived Extracellular Vesicles. Nutrition Research.0271-5317https://www.sciencedirect.com/science/article/pii/S0271531725000144http://hdl.handle.net/10576/641771351879-0739enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/641772025-07-15T19:08:16Z |
| spellingShingle | Beyond nutrition: The emerging therapeutic potential landscape of breast milk-derived extracellular vesicles Hend, Al-Jaber Breast milk Therapy Exosomes Extracellular vesicles Infant health |
| status_str | publishedVersion |
| title | Beyond nutrition: The emerging therapeutic potential landscape of breast milk-derived extracellular vesicles |
| title_full | Beyond nutrition: The emerging therapeutic potential landscape of breast milk-derived extracellular vesicles |
| title_fullStr | Beyond nutrition: The emerging therapeutic potential landscape of breast milk-derived extracellular vesicles |
| title_full_unstemmed | Beyond nutrition: The emerging therapeutic potential landscape of breast milk-derived extracellular vesicles |
| title_short | Beyond nutrition: The emerging therapeutic potential landscape of breast milk-derived extracellular vesicles |
| title_sort | Beyond nutrition: The emerging therapeutic potential landscape of breast milk-derived extracellular vesicles |
| topic | Breast milk Therapy Exosomes Extracellular vesicles Infant health |
| url | http://dx.doi.org/10.1016/j.nutres.2025.01.006 https://www.sciencedirect.com/science/article/pii/S0271531725000144 http://hdl.handle.net/10576/64177 |