Effects of previous infection, vaccination, and hybrid immunity against symptomatic Alpha, Beta, and Delta SARS-CoV-2 infections: an observational study
BackgroundProtection against SARS-CoV-2 symptomatic infection and severe COVID-19 of previous infection, mRNA two-dose vaccination, mRNA three-dose vaccination, and hybrid immunity of previous infection and vaccination were investigated in Qatar for the Alpha, Beta, and Delta variants. MethodsSix na...
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2023
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| Online Access: | http://dx.doi.org/10.1016/j.ebiom.2023.104734 https://www.sciencedirect.com/science/article/pii/S2352396423002992 http://hdl.handle.net/10576/47966 |
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| _version_ | 1857415086763671552 |
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| author | Heba N., Altarawneh |
| author2 | Chemaitelly, Hiam Ayoub, Houssein H. Tang, Patrick Hasan, Mohammad R. Yassine, Hadi M. Al-Khatib, Hebah A. Al Thani, Asmaa A. Coyle, Peter Al-Kanaani, Zaina Al-Kuwari, Einas Jeremijenko, Andrew Kaleeckal, Anvar Hassan Latif, Ali Nizar Shaik, Riyazuddin Mohammad Abdul-Rahim, Hanan F. Nasrallah, Gheyath K. Al-Kuwari, Mohamed Ghaith Butt, Adeel A. Al-Romaihi, Hamad Eid Al-Thani, Mohamed H. Al-Khal, Abdullatif Bertollini, Roberto Abu-Raddad, Laith J. |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Heba N., Altarawneh Chemaitelly, Hiam Ayoub, Houssein H. Tang, Patrick Hasan, Mohammad R. Yassine, Hadi M. Al-Khatib, Hebah A. Al Thani, Asmaa A. Coyle, Peter Al-Kanaani, Zaina Al-Kuwari, Einas Jeremijenko, Andrew Kaleeckal, Anvar Hassan Latif, Ali Nizar Shaik, Riyazuddin Mohammad Abdul-Rahim, Hanan F. Nasrallah, Gheyath K. Al-Kuwari, Mohamed Ghaith Butt, Adeel A. Al-Romaihi, Hamad Eid Al-Thani, Mohamed H. Al-Khal, Abdullatif Bertollini, Roberto Abu-Raddad, Laith J. |
| author_role | author |
| dc.creator.none.fl_str_mv | Heba N., Altarawneh Chemaitelly, Hiam Ayoub, Houssein H. Tang, Patrick Hasan, Mohammad R. Yassine, Hadi M. Al-Khatib, Hebah A. Al Thani, Asmaa A. Coyle, Peter Al-Kanaani, Zaina Al-Kuwari, Einas Jeremijenko, Andrew Kaleeckal, Anvar Hassan Latif, Ali Nizar Shaik, Riyazuddin Mohammad Abdul-Rahim, Hanan F. Nasrallah, Gheyath K. Al-Kuwari, Mohamed Ghaith Butt, Adeel A. Al-Romaihi, Hamad Eid Al-Thani, Mohamed H. Al-Khal, Abdullatif Bertollini, Roberto Abu-Raddad, Laith J. |
| dc.date.none.fl_str_mv | 2023-09-26T06:51:13Z 2023-09-30 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.ebiom.2023.104734 23523964 https://www.sciencedirect.com/science/article/pii/S2352396423002992 http://hdl.handle.net/10576/47966 95 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | COVID-19 Booster Reinfection Variant Case-control Test-negative |
| dc.title.none.fl_str_mv | Effects of previous infection, vaccination, and hybrid immunity against symptomatic Alpha, Beta, and Delta SARS-CoV-2 infections: an observational study |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | BackgroundProtection against SARS-CoV-2 symptomatic infection and severe COVID-19 of previous infection, mRNA two-dose vaccination, mRNA three-dose vaccination, and hybrid immunity of previous infection and vaccination were investigated in Qatar for the Alpha, Beta, and Delta variants. MethodsSix national, matched, test-negative, case-control studies were conducted between January 18 and December 18, 2021 on a sample of 239,120 PCR-positive tests and 6,103,365 PCR-negative tests. FindingsEffectiveness of previous infection against Alpha, Beta, and Delta reinfection was 89.5% (95% CI: 85.5–92.3%), 87.9% (95% CI: 85.4–89.9%), and 90.0% (95% CI: 86.7–92.5%), respectively. Effectiveness of two-dose BNT162b2 vaccination against Alpha, Beta, and Delta infection was 90.5% (95% CI, 83.9–94.4%), 80.5% (95% CI: 79.0–82.0%), and 58.1% (95% CI: 54.6–61.3%), respectively. Effectiveness of three-dose BNT162b2 vaccination against Delta infection was 91.7% (95% CI: 87.1–94.7%). Effectiveness of hybrid immunity of previous infection and two-dose BNT162b2 vaccination was 97.4% (95% CI: 95.4–98.5%) against Beta infection and 94.5% (95% CI: 92.8–95.8%) against Delta infection. Effectiveness of previous infection and three-dose BNT162b2 vaccination was 98.1% (95% CI: 85.7–99.7%) against Delta infection. All five forms of immunity had >90% protection against severe, critical, or fatal COVID-19 regardless of variant. Similar effectiveness estimates were observed for mRNA-1273. A mathematical model accurately predicted hybrid immunity protection by assuming that the individual effects of previous infection and vaccination acted independently. InterpretationHybrid immunity, offering the strongest protection, was mathematically predicted by assuming that the immunities obtained from previous infection and vaccination act independently, without synergy or redundancy. FundingThe Biomedical Research Program and the Biostatistics, Epidemiology, and the Biomathematics Research Core, both at Weill Cornell Medicine-Qatar, Ministry of Public Health, Hamad Medical Corporation, Sidra Medicine, Qatar Genome Programme, Qatar University Biomedical Research Center, and Qatar University Internal Grant ID QUCG-CAS-23/24-114. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_54a38bd2fdeaddbac27edfad011a8ee5 |
| identifier_str_mv | 23523964 95 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/47966 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Effects of previous infection, vaccination, and hybrid immunity against symptomatic Alpha, Beta, and Delta SARS-CoV-2 infections: an observational studyHeba N., AltarawnehChemaitelly, HiamAyoub, Houssein H.Tang, PatrickHasan, Mohammad R.Yassine, Hadi M.Al-Khatib, Hebah A.Al Thani, Asmaa A.Coyle, PeterAl-Kanaani, ZainaAl-Kuwari, EinasJeremijenko, AndrewKaleeckal, Anvar HassanLatif, Ali NizarShaik, Riyazuddin MohammadAbdul-Rahim, Hanan F.Nasrallah, Gheyath K.Al-Kuwari, Mohamed GhaithButt, Adeel A.Al-Romaihi, Hamad EidAl-Thani, Mohamed H.Al-Khal, AbdullatifBertollini, RobertoAbu-Raddad, Laith J.COVID-19BoosterReinfectionVariantCase-controlTest-negativeBackgroundProtection against SARS-CoV-2 symptomatic infection and severe COVID-19 of previous infection, mRNA two-dose vaccination, mRNA three-dose vaccination, and hybrid immunity of previous infection and vaccination were investigated in Qatar for the Alpha, Beta, and Delta variants. MethodsSix national, matched, test-negative, case-control studies were conducted between January 18 and December 18, 2021 on a sample of 239,120 PCR-positive tests and 6,103,365 PCR-negative tests. FindingsEffectiveness of previous infection against Alpha, Beta, and Delta reinfection was 89.5% (95% CI: 85.5–92.3%), 87.9% (95% CI: 85.4–89.9%), and 90.0% (95% CI: 86.7–92.5%), respectively. Effectiveness of two-dose BNT162b2 vaccination against Alpha, Beta, and Delta infection was 90.5% (95% CI, 83.9–94.4%), 80.5% (95% CI: 79.0–82.0%), and 58.1% (95% CI: 54.6–61.3%), respectively. Effectiveness of three-dose BNT162b2 vaccination against Delta infection was 91.7% (95% CI: 87.1–94.7%). Effectiveness of hybrid immunity of previous infection and two-dose BNT162b2 vaccination was 97.4% (95% CI: 95.4–98.5%) against Beta infection and 94.5% (95% CI: 92.8–95.8%) against Delta infection. Effectiveness of previous infection and three-dose BNT162b2 vaccination was 98.1% (95% CI: 85.7–99.7%) against Delta infection. All five forms of immunity had >90% protection against severe, critical, or fatal COVID-19 regardless of variant. Similar effectiveness estimates were observed for mRNA-1273. A mathematical model accurately predicted hybrid immunity protection by assuming that the individual effects of previous infection and vaccination acted independently. InterpretationHybrid immunity, offering the strongest protection, was mathematically predicted by assuming that the immunities obtained from previous infection and vaccination act independently, without synergy or redundancy. FundingThe Biomedical Research Program and the Biostatistics, Epidemiology, and the Biomathematics Research Core, both at Weill Cornell Medicine-Qatar, Ministry of Public Health, Hamad Medical Corporation, Sidra Medicine, Qatar Genome Programme, Qatar University Biomedical Research Center, and Qatar University Internal Grant ID QUCG-CAS-23/24-114.The Biomedical Research Program and the Biostatistics, Epidemiology, and the Biomathematics Research Core, both at Weill Cornell Medicine-Qatar, Ministry of Public Health, Hamad Medical Corporation, Sidra Medicine, Qatar Genome Programme, Qatar University Biomedical Research Center, and Qatar University Internal Grant ID QUCG-CAS-23/24-114.Elsevier2023-09-26T06:51:13Z2023-09-30Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.ebiom.2023.10473423523964https://www.sciencedirect.com/science/article/pii/S2352396423002992http://hdl.handle.net/10576/4796695enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/479662024-07-23T15:51:34Z |
| spellingShingle | Effects of previous infection, vaccination, and hybrid immunity against symptomatic Alpha, Beta, and Delta SARS-CoV-2 infections: an observational study Heba N., Altarawneh COVID-19 Booster Reinfection Variant Case-control Test-negative |
| status_str | publishedVersion |
| title | Effects of previous infection, vaccination, and hybrid immunity against symptomatic Alpha, Beta, and Delta SARS-CoV-2 infections: an observational study |
| title_full | Effects of previous infection, vaccination, and hybrid immunity against symptomatic Alpha, Beta, and Delta SARS-CoV-2 infections: an observational study |
| title_fullStr | Effects of previous infection, vaccination, and hybrid immunity against symptomatic Alpha, Beta, and Delta SARS-CoV-2 infections: an observational study |
| title_full_unstemmed | Effects of previous infection, vaccination, and hybrid immunity against symptomatic Alpha, Beta, and Delta SARS-CoV-2 infections: an observational study |
| title_short | Effects of previous infection, vaccination, and hybrid immunity against symptomatic Alpha, Beta, and Delta SARS-CoV-2 infections: an observational study |
| title_sort | Effects of previous infection, vaccination, and hybrid immunity against symptomatic Alpha, Beta, and Delta SARS-CoV-2 infections: an observational study |
| topic | COVID-19 Booster Reinfection Variant Case-control Test-negative |
| url | http://dx.doi.org/10.1016/j.ebiom.2023.104734 https://www.sciencedirect.com/science/article/pii/S2352396423002992 http://hdl.handle.net/10576/47966 |