50,000 years of evolutionary history of India: Impact on health and disease variation

50,000 years of evolutionary history of India: Impact on health and disease variation

India has been underrepresented in genomic surveys. We generated whole-genome sequences from 2,762 individuals in India, capturing the genetic diversity across most geographic regions, linguistic groups, and historically underrepresented communities. We find most Indians harbor ancestry primarily fr...

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Main Author: Skov, Laurits (author)
Other Authors: Patterson, Nick (author), Banerjee, Joyita (author), Khobragade, Pranali (author), Chakrabarti, Sankha S. (author), Chakrawarty, Avinash (author), Chatterjee, Prasun (author), Dhar, Minakshi (author), Gupta, Monica (author), John, John P. (author), Koul, Parvaiz A. (author), Lehl, Sarabmeet S. (author), Mohanty, Rashmi R. (author), Padmaja, Mekala (author), Perianayagam, Arokiasamy (author), Rajguru, Chhaya (author), Sankhe, Lalit (author), Talukdar, Arunansu (author), Varghese, Mathew (author), Yadati, Sathyanarayana Raju (author), Zhao, Wei (author), Leung, Yuk Yee (author), Schellenberg, Gerard D. (author), Wang, Yi Zhe (author), Smith, Jennifer A. (author), Dey, Sharmistha (author), Ganna, Andrea (author), Dey, Aparajit Ballav (author), Kardia, Sharon L.R. (author), Lee, Jinkook (author), Moorjani, Priya (author), Kerdoncuff, Elise (author)
Format: article
Published: 2025
Subjects:
genomic diversity in India
South Asian evolutionary history
ancient gene flow
founder events
Neanderthal ancestry
Denisovan ancestry
functional variation
adaptation
disease susceptibility
peopling of India
Online Access:http://dx.doi.org/10.1016/j.cell.2025.04.027
https://www.sciencedirect.com/science/article/pii/S0092867425004623
http://hdl.handle.net/10576/66664
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