Crosstalk between aryl hydrocarbon receptor (AhR) and BCL-2 pathways suggests the use of AhR antagonist to maintain normal differentiation state of mammary epithelial cells during BCL-2 inhibition therapy

Crosstalk between aryl hydrocarbon receptor (AhR) and BCL-2 pathways suggests the use of AhR antagonist to maintain normal differentiation state of mammary epithelial cells during BCL-2 inhibition therapy

IntroductionActivating the aryl hydrocarbon receptor upon exposure to environmental pollutants promotes development of breast cancer stem cell (CSCs). BCL-2 family proteins protect cancer cells from the apoptotic effects of chemotherapeutic drugs. However, the crosstalk between AhR and the BCL-2 fam...

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Bibliographic Details
Main Author: Abdullah, Al-Dhfyan (author)
Other Authors: Alaiya, Ayodele (author), Al-Mohanna, Falah (author), Attwa, Mohamed W (author), AlAsmari, Abdullah F (author), Bakheet, Saleh A (author), Korashy, Hesham M. (author)
Format: article
Published: 2022
Subjects:
AhR/CYP1A1
Breast cancer stem cells
In vivo mice
BCL-2
Proteomics
Venetoclax
Online Access:http://dx.doi.org/10.1016/j.jare.2022.10.006
https://www.sciencedirect.com/science/article/pii/S209012322200234X
http://hdl.handle.net/10576/41421
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http://dx.doi.org/10.1016/j.jare.2022.10.006
https://www.sciencedirect.com/science/article/pii/S209012322200234X
http://hdl.handle.net/10576/41421

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