Natural resorcylic acid lactones: A chemical biology approach for anticancer activity
Resorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid residue (2,4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a broad range of biological activities, including anticancer activities. Following discovery of the selective Hsp90 inhibition...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , |
| التنسيق: | article |
| منشور في: |
2022
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.drudis.2021.10.001 https://www.sciencedirect.com/science/article/pii/S1359644621004323 http://hdl.handle.net/10576/41837 |
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| _version_ | 1857415085752844288 |
|---|---|
| author | Shilpa, Kuttikrishnan |
| author2 | Prabhu, Kirti S. Al Sharie, Ahmed H. Al Zu'bi, Yazan O. Alali, Feras Q. Oberlies, Nicholas H. Ahmad, Aamir El-Elimat, Tamam Uddin, Shahab |
| author2_role | author author author author author author author author |
| author_facet | Shilpa, Kuttikrishnan Prabhu, Kirti S. Al Sharie, Ahmed H. Al Zu'bi, Yazan O. Alali, Feras Q. Oberlies, Nicholas H. Ahmad, Aamir El-Elimat, Tamam Uddin, Shahab |
| author_role | author |
| dc.creator.none.fl_str_mv | Shilpa, Kuttikrishnan Prabhu, Kirti S. Al Sharie, Ahmed H. Al Zu'bi, Yazan O. Alali, Feras Q. Oberlies, Nicholas H. Ahmad, Aamir El-Elimat, Tamam Uddin, Shahab |
| dc.date.none.fl_str_mv | 2022-02-28 2023-04-12T05:34:39Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.drudis.2021.10.001 Kuttikrishnan, Shilpa, Kirti S. Prabhu, Ahmed H. Al Sharie, Yazan O. Al Zu'bi, Feras Q. Alali, Nicholas H. Oberlies, Aamir Ahmad, Tamam El-Elimat, and Shahab Uddin. "Natural resorcylic acid lactones: A chemical biology approach for anticancer activity." Drug Discovery Today 27, no. 2 (2022): 547-557. 13596446 https://www.sciencedirect.com/science/article/pii/S1359644621004323 http://hdl.handle.net/10576/41837 547-557 2 27 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Resorcylic acid lactones Heat shock protein 90 inhibitors Protein kinase inhibitors Radicicol Hypothemycin 5Z-7-oxo-zeaenol |
| dc.title.none.fl_str_mv | Natural resorcylic acid lactones: A chemical biology approach for anticancer activity |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Resorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid residue (2,4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a broad range of biological activities, including anticancer activities. Following discovery of the selective Hsp90 inhibition activity of radicicol, the kinase inhibition activity of hypothemycin, monocillin II, 5Z-7-oxo-zeaenol, and L-783,277 RALs, and the nuclear factor kappa B (NF-κB) inhibition activity of the RAL zearalenone, have attracted great attention as potential therapeutics for cancer treatment. In this minireview, we focus on natural RALs that possess cytotoxic activities [IC50 values < 10 μM (or 4–5 μg/ml)], discussing their structures, isolation, occurrence, biological activities, and anticancer molecular mechanisms. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_69481247cbdbc58a52639b605930d260 |
| identifier_str_mv | Kuttikrishnan, Shilpa, Kirti S. Prabhu, Ahmed H. Al Sharie, Yazan O. Al Zu'bi, Feras Q. Alali, Nicholas H. Oberlies, Aamir Ahmad, Tamam El-Elimat, and Shahab Uddin. "Natural resorcylic acid lactones: A chemical biology approach for anticancer activity." Drug Discovery Today 27, no. 2 (2022): 547-557. 13596446 547-557 2 27 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/41837 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Natural resorcylic acid lactones: A chemical biology approach for anticancer activityShilpa, KuttikrishnanPrabhu, Kirti S.Al Sharie, Ahmed H.Al Zu'bi, Yazan O.Alali, Feras Q.Oberlies, Nicholas H.Ahmad, AamirEl-Elimat, TamamUddin, ShahabResorcylic acid lactonesHeat shock protein 90 inhibitorsProtein kinase inhibitorsRadicicolHypothemycin5Z-7-oxo-zeaenolResorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid residue (2,4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a broad range of biological activities, including anticancer activities. Following discovery of the selective Hsp90 inhibition activity of radicicol, the kinase inhibition activity of hypothemycin, monocillin II, 5Z-7-oxo-zeaenol, and L-783,277 RALs, and the nuclear factor kappa B (NF-κB) inhibition activity of the RAL zearalenone, have attracted great attention as potential therapeutics for cancer treatment. In this minireview, we focus on natural RALs that possess cytotoxic activities [IC50 values < 10 μM (or 4–5 μg/ml)], discussing their structures, isolation, occurrence, biological activities, and anticancer molecular mechanisms.This work is supported by funding from the Medical Research Center (grant no. MRC-01-21-301 (SU)), Hamad Medical Corporation, Doha, Qatar. The authors acknowledge Qatar National Library, Doha, Qatar for supporting Open Access funding for this article.Elsevier2023-04-12T05:34:39Z2022-02-28Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.drudis.2021.10.001Kuttikrishnan, Shilpa, Kirti S. Prabhu, Ahmed H. Al Sharie, Yazan O. Al Zu'bi, Feras Q. Alali, Nicholas H. Oberlies, Aamir Ahmad, Tamam El-Elimat, and Shahab Uddin. "Natural resorcylic acid lactones: A chemical biology approach for anticancer activity." Drug Discovery Today 27, no. 2 (2022): 547-557.13596446https://www.sciencedirect.com/science/article/pii/S1359644621004323http://hdl.handle.net/10576/41837547-557227enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/418372024-07-23T10:58:21Z |
| spellingShingle | Natural resorcylic acid lactones: A chemical biology approach for anticancer activity Shilpa, Kuttikrishnan Resorcylic acid lactones Heat shock protein 90 inhibitors Protein kinase inhibitors Radicicol Hypothemycin 5Z-7-oxo-zeaenol |
| status_str | publishedVersion |
| title | Natural resorcylic acid lactones: A chemical biology approach for anticancer activity |
| title_full | Natural resorcylic acid lactones: A chemical biology approach for anticancer activity |
| title_fullStr | Natural resorcylic acid lactones: A chemical biology approach for anticancer activity |
| title_full_unstemmed | Natural resorcylic acid lactones: A chemical biology approach for anticancer activity |
| title_short | Natural resorcylic acid lactones: A chemical biology approach for anticancer activity |
| title_sort | Natural resorcylic acid lactones: A chemical biology approach for anticancer activity |
| topic | Resorcylic acid lactones Heat shock protein 90 inhibitors Protein kinase inhibitors Radicicol Hypothemycin 5Z-7-oxo-zeaenol |
| url | http://dx.doi.org/10.1016/j.drudis.2021.10.001 https://www.sciencedirect.com/science/article/pii/S1359644621004323 http://hdl.handle.net/10576/41837 |