The effect of novel nitrogen-based chalcone analogs on colorectal cancer cells: Insight into the molecular pathways

The effect of novel nitrogen-based chalcone analogs on colorectal cancer cells: Insight into the molecular pathways

In colorectal cancer (CRC), aberrations in KRAS are associated with aggressive tumorigenesis and an overall low survival rate because of chemoresistance and adverse effects. Ergo, complementary, and integrative medicines are being considered for CRC treatment. Among which is the use of natural chalc...

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Bibliographic Details
Main Author: Arij Fouzat, Hassan (author)
Other Authors: Hussein, Ola (author), Al-Barazenji, Tara (author), Allouch, Asma (author), Kamareddine, Layla (author), Malki, Ahmed (author), Moustafa, Ala‐Eddin Al (author), Khalil, Ashraf (author)
Format: article
Published: 2024
Subjects:
Colorectal cancer (CRC)
Chalcone
Nitrogen mustard
Methoxy
Analogs
Epithelial-mesenchymal transition (EMT)
Online Access:http://dx.doi.org/10.1016/j.heliyon.2024.e27002
https://www.sciencedirect.com/science/article/pii/S2405844024030330
http://hdl.handle.net/10576/53719
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