Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells
Cancer remains one of the leading causes of mortality worldwide, presenting a significant healthcare challenge owing to the limited efficacy of current treatments. The application of nanotechnology in cancer treatment leverages the unique optical, magnetic, and electrical attributes of nanomaterials...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , |
| التنسيق: | article |
| منشور في: |
2023
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.ejps.2023.106586 https://www.sciencedirect.com/science/article/pii/S0928098723002166 http://hdl.handle.net/10576/51326 |
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| _version_ | 1857415084992626688 |
|---|---|
| author | Queenie, Fernandes |
| author2 | Therachiyil, Lubna Khan, Abdul Q. Bedhiafi, Takwa Korashy, Hesham M Bhat, Ajaz A. Uddin, Shahab |
| author2_role | author author author author author author |
| author_facet | Queenie, Fernandes Therachiyil, Lubna Khan, Abdul Q. Bedhiafi, Takwa Korashy, Hesham M Bhat, Ajaz A. Uddin, Shahab |
| author_role | author |
| dc.creator.none.fl_str_mv | Queenie, Fernandes Therachiyil, Lubna Khan, Abdul Q. Bedhiafi, Takwa Korashy, Hesham M Bhat, Ajaz A. Uddin, Shahab |
| dc.date.none.fl_str_mv | 2023-09-19 2024-01-29T11:01:03Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.ejps.2023.106586 Fernandes, Q., Therachiyil, L., Khan, A. Q., Bedhiafi, T., Korashy, H. M., Bhat, A. A., & Uddin, S. (2023). Shrinking the Battlefield in Cancer Therapy: Nanotechnology Against Cancer Stem Cells. European Journal of Pharmaceutical Sciences, 106586. 0928-0987 https://www.sciencedirect.com/science/article/pii/S0928098723002166 http://hdl.handle.net/10576/51326 191 1879-0720 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Nanotherapy Cancer stem cells Signaling pathways Pharmacokinetics Drug resistance |
| dc.title.none.fl_str_mv | Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Cancer remains one of the leading causes of mortality worldwide, presenting a significant healthcare challenge owing to the limited efficacy of current treatments. The application of nanotechnology in cancer treatment leverages the unique optical, magnetic, and electrical attributes of nanomaterials to engineer innovative, targeted therapies. Specifically, manipulating nanomaterials allows for enhanced drug loading efficiency, improved bioavailability, and targeted delivery systems, reducing the non-specific cytotoxic effects characteristic of conventional chemotherapies. Furthermore, recent advances in nanotechnology have demonstrated encouraging results in specifically targeting CSCs, a key development considering the role of these cells in disease recurrence and resistance to treatment. Despite these breakthroughs, the clinical approval rates of nano-drugs have not kept pace with research advances, pointing to existing obstacles that must be addressed. In conclusion, nanotechnology presents a novel, powerful tool in the fight against cancer, particularly in targeting the elusive and treatment-resistant CSCs. This comprehensive review delves into the intricacies of nanotherapy, explicitly targeting cancer stem cells, their markers, and associated signaling pathways. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_6c78bb4b56eaea566843cd38b05a45ee |
| identifier_str_mv | Fernandes, Q., Therachiyil, L., Khan, A. Q., Bedhiafi, T., Korashy, H. M., Bhat, A. A., & Uddin, S. (2023). Shrinking the Battlefield in Cancer Therapy: Nanotechnology Against Cancer Stem Cells. European Journal of Pharmaceutical Sciences, 106586. 0928-0987 191 1879-0720 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/51326 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cellsQueenie, FernandesTherachiyil, LubnaKhan, Abdul Q.Bedhiafi, TakwaKorashy, Hesham MBhat, Ajaz A.Uddin, ShahabNanotherapyCancer stem cellsSignaling pathwaysPharmacokineticsDrug resistanceCancer remains one of the leading causes of mortality worldwide, presenting a significant healthcare challenge owing to the limited efficacy of current treatments. The application of nanotechnology in cancer treatment leverages the unique optical, magnetic, and electrical attributes of nanomaterials to engineer innovative, targeted therapies. Specifically, manipulating nanomaterials allows for enhanced drug loading efficiency, improved bioavailability, and targeted delivery systems, reducing the non-specific cytotoxic effects characteristic of conventional chemotherapies. Furthermore, recent advances in nanotechnology have demonstrated encouraging results in specifically targeting CSCs, a key development considering the role of these cells in disease recurrence and resistance to treatment. Despite these breakthroughs, the clinical approval rates of nano-drugs have not kept pace with research advances, pointing to existing obstacles that must be addressed. In conclusion, nanotechnology presents a novel, powerful tool in the fight against cancer, particularly in targeting the elusive and treatment-resistant CSCs. This comprehensive review delves into the intricacies of nanotherapy, explicitly targeting cancer stem cells, their markers, and associated signaling pathways.Open access is provided by Qatar National Library.Elsevier2024-01-29T11:01:03Z2023-09-19Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.ejps.2023.106586Fernandes, Q., Therachiyil, L., Khan, A. Q., Bedhiafi, T., Korashy, H. M., Bhat, A. A., & Uddin, S. (2023). Shrinking the Battlefield in Cancer Therapy: Nanotechnology Against Cancer Stem Cells. European Journal of Pharmaceutical Sciences, 106586.0928-0987https://www.sciencedirect.com/science/article/pii/S0928098723002166http://hdl.handle.net/10576/513261911879-0720enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/513262024-07-23T15:52:37Z |
| spellingShingle | Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells Queenie, Fernandes Nanotherapy Cancer stem cells Signaling pathways Pharmacokinetics Drug resistance |
| status_str | publishedVersion |
| title | Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells |
| title_full | Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells |
| title_fullStr | Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells |
| title_full_unstemmed | Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells |
| title_short | Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells |
| title_sort | Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells |
| topic | Nanotherapy Cancer stem cells Signaling pathways Pharmacokinetics Drug resistance |
| url | http://dx.doi.org/10.1016/j.ejps.2023.106586 https://www.sciencedirect.com/science/article/pii/S0928098723002166 http://hdl.handle.net/10576/51326 |