Studies on anti-colon cancer potential of nanoformulations of curcumin and succinylated curcumin in mannosylated chitosan
Colon cancer (CRC) is the second leading cause of death and the third most diagnosed cancer worldwide. Although curcumin (CUR) has demonstrated a potent anticancer activity, it is characterized by its poor solubility, low bioavailability, and instability. This study is a projection from a previous i...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , |
| التنسيق: | article |
| منشور في: |
2023
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.ijbiomac.2023.123827 https://www.sciencedirect.com/science/article/pii/S0141813023007213 http://hdl.handle.net/10576/42260 |
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| _version_ | 1857415084488261632 |
|---|---|
| author | Sourour, Idoudi |
| author2 | Bedhiafi, Takwa Sahir, Fairooz Hijji, Yousef Uddin, Shahab Merhi, Maysaloun Dermime, Said Billa, Nashiru |
| author2_role | author author author author author author author |
| author_facet | Sourour, Idoudi Bedhiafi, Takwa Sahir, Fairooz Hijji, Yousef Uddin, Shahab Merhi, Maysaloun Dermime, Said Billa, Nashiru |
| author_role | author |
| dc.creator.none.fl_str_mv | Sourour, Idoudi Bedhiafi, Takwa Sahir, Fairooz Hijji, Yousef Uddin, Shahab Merhi, Maysaloun Dermime, Said Billa, Nashiru |
| dc.date.none.fl_str_mv | 2023-05-03T06:39:42Z 2023-02-27 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.ijbiomac.2023.123827 Idoudi, S., Bedhiafi, T., Sahir, F., Hijji, Y., Uddin, S., Merhi, M., ... & Billa, N. (2023). Studies on anti-colon cancer potential of nanoformulations of curcumin and succinylated curcumin in mannosylated chitosan. International Journal of Biological Macromolecules, 235, 123827. 0141-8130 https://www.sciencedirect.com/science/article/pii/S0141813023007213 http://hdl.handle.net/10576/42260 235 1879-0003 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Curcumin Mannose Chitosan nanoparticles Colorectal cancer Cytotoxicity |
| dc.title.none.fl_str_mv | Studies on anti-colon cancer potential of nanoformulations of curcumin and succinylated curcumin in mannosylated chitosan |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Colon cancer (CRC) is the second leading cause of death and the third most diagnosed cancer worldwide. Although curcumin (CUR) has demonstrated a potent anticancer activity, it is characterized by its poor solubility, low bioavailability, and instability. This study is a projection from a previous investigation where CUR and succinylated CUR (CUR.SA) were separately encapsulated in mannosylated-chitosan nanoparticles (CM-NPs) to form CUR-NPs and CUR.SA-NPs, respectively. Here, we aim to assess the anti-CRC activity of these two nanoformulations. Cytotoxicity studies using CCK-8 assay indicated that both CUR-NPs and CUR.SA-NPs have a dose and time-dependent toxicity towards CRC human cell-lines (HCT116 and SW480), and more cytotoxic compared to free CUR or CUR-SA in a time-dependent manner. A significant induction of early and late apoptosis in the CUR-NPs and CUR.SA-NPs treated CRC cell lines compared to untreated cells was observed. Western blotting analyses confirmed the induction of apoptosis through activation of Caspase signaling compared to untreated cells. Based on the physicochemical properties of CUR-NPs and CUR.SA-NPs along with the data from the in vitro studies, we may conclude these nanoparticle formulations hold very promising attributes, worthy of further investigations for its role in the management of CRC. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_6e6a573b9876d2eb0d2765c50f60f956 |
| identifier_str_mv | Idoudi, S., Bedhiafi, T., Sahir, F., Hijji, Y., Uddin, S., Merhi, M., ... & Billa, N. (2023). Studies on anti-colon cancer potential of nanoformulations of curcumin and succinylated curcumin in mannosylated chitosan. International Journal of Biological Macromolecules, 235, 123827. 0141-8130 235 1879-0003 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/42260 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Studies on anti-colon cancer potential of nanoformulations of curcumin and succinylated curcumin in mannosylated chitosanSourour, IdoudiBedhiafi, TakwaSahir, FairoozHijji, YousefUddin, ShahabMerhi, MaysalounDermime, SaidBilla, NashiruCurcuminMannoseChitosan nanoparticlesColorectal cancerCytotoxicityColon cancer (CRC) is the second leading cause of death and the third most diagnosed cancer worldwide. Although curcumin (CUR) has demonstrated a potent anticancer activity, it is characterized by its poor solubility, low bioavailability, and instability. This study is a projection from a previous investigation where CUR and succinylated CUR (CUR.SA) were separately encapsulated in mannosylated-chitosan nanoparticles (CM-NPs) to form CUR-NPs and CUR.SA-NPs, respectively. Here, we aim to assess the anti-CRC activity of these two nanoformulations. Cytotoxicity studies using CCK-8 assay indicated that both CUR-NPs and CUR.SA-NPs have a dose and time-dependent toxicity towards CRC human cell-lines (HCT116 and SW480), and more cytotoxic compared to free CUR or CUR-SA in a time-dependent manner. A significant induction of early and late apoptosis in the CUR-NPs and CUR.SA-NPs treated CRC cell lines compared to untreated cells was observed. Western blotting analyses confirmed the induction of apoptosis through activation of Caspase signaling compared to untreated cells. Based on the physicochemical properties of CUR-NPs and CUR.SA-NPs along with the data from the in vitro studies, we may conclude these nanoparticle formulations hold very promising attributes, worthy of further investigations for its role in the management of CRC.This work was funded by Qatar University Grant No IRCC-2021-006 .Elsevier2023-05-03T06:39:42Z2023-02-27Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.ijbiomac.2023.123827Idoudi, S., Bedhiafi, T., Sahir, F., Hijji, Y., Uddin, S., Merhi, M., ... & Billa, N. (2023). Studies on anti-colon cancer potential of nanoformulations of curcumin and succinylated curcumin in mannosylated chitosan. International Journal of Biological Macromolecules, 235, 123827.0141-8130https://www.sciencedirect.com/science/article/pii/S0141813023007213http://hdl.handle.net/10576/422602351879-0003enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/422602024-07-23T13:53:03Z |
| spellingShingle | Studies on anti-colon cancer potential of nanoformulations of curcumin and succinylated curcumin in mannosylated chitosan Sourour, Idoudi Curcumin Mannose Chitosan nanoparticles Colorectal cancer Cytotoxicity |
| status_str | publishedVersion |
| title | Studies on anti-colon cancer potential of nanoformulations of curcumin and succinylated curcumin in mannosylated chitosan |
| title_full | Studies on anti-colon cancer potential of nanoformulations of curcumin and succinylated curcumin in mannosylated chitosan |
| title_fullStr | Studies on anti-colon cancer potential of nanoformulations of curcumin and succinylated curcumin in mannosylated chitosan |
| title_full_unstemmed | Studies on anti-colon cancer potential of nanoformulations of curcumin and succinylated curcumin in mannosylated chitosan |
| title_short | Studies on anti-colon cancer potential of nanoformulations of curcumin and succinylated curcumin in mannosylated chitosan |
| title_sort | Studies on anti-colon cancer potential of nanoformulations of curcumin and succinylated curcumin in mannosylated chitosan |
| topic | Curcumin Mannose Chitosan nanoparticles Colorectal cancer Cytotoxicity |
| url | http://dx.doi.org/10.1016/j.ijbiomac.2023.123827 https://www.sciencedirect.com/science/article/pii/S0141813023007213 http://hdl.handle.net/10576/42260 |