Etiology of exudative pleural effusion among adults: differentiating between tuberculous and other causes, a multicenter prospective cohort study
ObjectivesExudative pleural effusions have a broad etiology and usually necessitate further investigative workup, including invasive procedures. This study aimed to evaluate and compare the demographic, clinical, and biochemical characteristics of tuberculous, malignant, and chronic inflammatory ple...
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2024
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| Online Access: | http://dx.doi.org/10.1016/j.ijregi.2024.100425 https://www.sciencedirect.com/science/article/pii/S2772707624000961 http://hdl.handle.net/10576/61514 |
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| _version_ | 1857415086611628032 |
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| author | Mousa, Hussein |
| author2 | Thomas, Merlin Al-Tikrity, Mustafa Elarabi, Anam Hameed, Mansoor Al-Adab, Aisha Ibrahim, Wanis Chandra, Prem Ahmed, Shakeel Muslim, Muhammad Al-Qahoush, Osaid Raza, Tasleem |
| author2_role | author author author author author author author author author author author |
| author_facet | Mousa, Hussein Thomas, Merlin Al-Tikrity, Mustafa Elarabi, Anam Hameed, Mansoor Al-Adab, Aisha Ibrahim, Wanis Chandra, Prem Ahmed, Shakeel Muslim, Muhammad Al-Qahoush, Osaid Raza, Tasleem |
| author_role | author |
| dc.creator.none.fl_str_mv | Mousa, Hussein Thomas, Merlin Al-Tikrity, Mustafa Elarabi, Anam Hameed, Mansoor Al-Adab, Aisha Ibrahim, Wanis Chandra, Prem Ahmed, Shakeel Muslim, Muhammad Al-Qahoush, Osaid Raza, Tasleem |
| dc.date.none.fl_str_mv | 2024-11-26T11:23:33Z 2024-09 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.ijregi.2024.100425 Hussein, M., Thomas, M., Al-Tikrity, M., Elarabi, A., Hameed, M., Al-Adab, A., ... & Raza, T. (2024). Etiology of exudative pleural effusion among adults: differentiating between tuberculous and other causes, a multicenter prospective cohort study. IJID regions, 100425. 2772-7076 https://www.sciencedirect.com/science/article/pii/S2772707624000961 http://hdl.handle.net/10576/61514 12 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Pleural effusion Tuberculous Thoracentesis Thoracoscopy |
| dc.title.none.fl_str_mv | Etiology of exudative pleural effusion among adults: differentiating between tuberculous and other causes, a multicenter prospective cohort study |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | ObjectivesExudative pleural effusions have a broad etiology and usually necessitate further investigative workup, including invasive procedures. This study aimed to evaluate and compare the demographic, clinical, and biochemical characteristics of tuberculous, malignant, and chronic inflammatory pleural effusions. MethodsThis is a 2-year prospective cohort study of patients referred for medical thoracoscopy with an exudative pleural effusion. ResultsA total of 159 patients were enrolled in the study, with a mean age of 42.49 ± 13.8 years and the majority being males 121 (76.1%). As expected, patients with tuberculous effusions were significantly younger than those with non-tuberculous effusions (37.7 ± 10.9 vs 49.1 ± 14.9, P <0.001). Serum analysis showed significantly lower white blood cell count (7.5 × 109/L ± 2.7 vs 9.0 × 109/L ± 3.3, P = 0.004), higher total protein (76.2 g/dL ± 10.1 vs 70.2 g/dL ± 8.9, P <0.001), and higher median C-reactive protein (median 77.5, interquartile range 51-116 vs median 40.5, interquartile range 8-127, P <0.001) among tuberculous compared with non-tuberculosis effusions. ConclusionsOur study validates previous findings showing similar results in patients with tuberculous pleural effusions. A predictive model incorporating different demographic and clinical/laboratory characteristics may be useful in the early etiologic characterization of exudative pleural effusion. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_73fb9fd92f9ca832f131e81552060cc4 |
| identifier_str_mv | Hussein, M., Thomas, M., Al-Tikrity, M., Elarabi, A., Hameed, M., Al-Adab, A., ... & Raza, T. (2024). Etiology of exudative pleural effusion among adults: differentiating between tuberculous and other causes, a multicenter prospective cohort study. IJID regions, 100425. 2772-7076 12 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/61514 |
| publishDate | 2024 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| spelling | Etiology of exudative pleural effusion among adults: differentiating between tuberculous and other causes, a multicenter prospective cohort studyMousa, HusseinThomas, MerlinAl-Tikrity, MustafaElarabi, AnamHameed, MansoorAl-Adab, AishaIbrahim, WanisChandra, PremAhmed, ShakeelMuslim, MuhammadAl-Qahoush, OsaidRaza, TasleemPleural effusionTuberculousThoracentesisThoracoscopyObjectivesExudative pleural effusions have a broad etiology and usually necessitate further investigative workup, including invasive procedures. This study aimed to evaluate and compare the demographic, clinical, and biochemical characteristics of tuberculous, malignant, and chronic inflammatory pleural effusions. MethodsThis is a 2-year prospective cohort study of patients referred for medical thoracoscopy with an exudative pleural effusion. ResultsA total of 159 patients were enrolled in the study, with a mean age of 42.49 ± 13.8 years and the majority being males 121 (76.1%). As expected, patients with tuberculous effusions were significantly younger than those with non-tuberculous effusions (37.7 ± 10.9 vs 49.1 ± 14.9, P <0.001). Serum analysis showed significantly lower white blood cell count (7.5 × 109/L ± 2.7 vs 9.0 × 109/L ± 3.3, P = 0.004), higher total protein (76.2 g/dL ± 10.1 vs 70.2 g/dL ± 8.9, P <0.001), and higher median C-reactive protein (median 77.5, interquartile range 51-116 vs median 40.5, interquartile range 8-127, P <0.001) among tuberculous compared with non-tuberculosis effusions. ConclusionsOur study validates previous findings showing similar results in patients with tuberculous pleural effusions. A predictive model incorporating different demographic and clinical/laboratory characteristics may be useful in the early etiologic characterization of exudative pleural effusion.This work was supported and funded by Hamad Medical corporration - Medical research center.Elsevier2024-11-26T11:23:33Z2024-09Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.ijregi.2024.100425Hussein, M., Thomas, M., Al-Tikrity, M., Elarabi, A., Hameed, M., Al-Adab, A., ... & Raza, T. (2024). Etiology of exudative pleural effusion among adults: differentiating between tuberculous and other causes, a multicenter prospective cohort study. IJID regions, 100425.2772-7076https://www.sciencedirect.com/science/article/pii/S2772707624000961http://hdl.handle.net/10576/6151412enhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/615142024-11-26T19:06:17Z |
| spellingShingle | Etiology of exudative pleural effusion among adults: differentiating between tuberculous and other causes, a multicenter prospective cohort study Mousa, Hussein Pleural effusion Tuberculous Thoracentesis Thoracoscopy |
| status_str | publishedVersion |
| title | Etiology of exudative pleural effusion among adults: differentiating between tuberculous and other causes, a multicenter prospective cohort study |
| title_full | Etiology of exudative pleural effusion among adults: differentiating between tuberculous and other causes, a multicenter prospective cohort study |
| title_fullStr | Etiology of exudative pleural effusion among adults: differentiating between tuberculous and other causes, a multicenter prospective cohort study |
| title_full_unstemmed | Etiology of exudative pleural effusion among adults: differentiating between tuberculous and other causes, a multicenter prospective cohort study |
| title_short | Etiology of exudative pleural effusion among adults: differentiating between tuberculous and other causes, a multicenter prospective cohort study |
| title_sort | Etiology of exudative pleural effusion among adults: differentiating between tuberculous and other causes, a multicenter prospective cohort study |
| topic | Pleural effusion Tuberculous Thoracentesis Thoracoscopy |
| url | http://dx.doi.org/10.1016/j.ijregi.2024.100425 https://www.sciencedirect.com/science/article/pii/S2772707624000961 http://hdl.handle.net/10576/61514 |