microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review
Non-coding RNAs (ncRNAs) are a diverse group of functional RNA molecules that lack the ability to code for proteins. Despite missing this traditional role, ncRNAs have emerged as crucial regulators of various biological processes and have been implicated in the development and progression of many di...
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| مؤلفون آخرون: | , , , , , |
| التنسيق: | article |
| منشور في: |
2024
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.ncrna.2024.03.013 https://www.sciencedirect.com/science/article/pii/S2468054024000817 http://hdl.handle.net/10576/55187 |
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| _version_ | 1857415084376064000 |
|---|---|
| author | Roberta, Giordo |
| author2 | Ahmadi, Fatemeh Abdullah M. Husaini, Nedal Al Al-Nuaimi, Noora Rashid A.M. Ahmad, Salma M.S. Pintus, Gianfranco Zayed, Hatem |
| author2_role | author author author author author author |
| author_facet | Roberta, Giordo Ahmadi, Fatemeh Abdullah M. Husaini, Nedal Al Al-Nuaimi, Noora Rashid A.M. Ahmad, Salma M.S. Pintus, Gianfranco Zayed, Hatem |
| author_role | author |
| dc.creator.none.fl_str_mv | Roberta, Giordo Ahmadi, Fatemeh Abdullah M. Husaini, Nedal Al Al-Nuaimi, Noora Rashid A.M. Ahmad, Salma M.S. Pintus, Gianfranco Zayed, Hatem |
| dc.date.none.fl_str_mv | 2024-05-20T08:16:08Z 2024-03-31 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.ncrna.2024.03.013 Giordo, R., Ahmadi, F. A. M., Al Husaini, N., Al-Nuaimi, N. R. A., Ahmad, S. M., Pintus, G., & Zayed, H. (2024). microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review. Non-coding RNA Research. 2468-2160 https://www.sciencedirect.com/science/article/pii/S2468054024000817 http://hdl.handle.net/10576/55187 3 9 2468-0540 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | lncRNAs miRNAs Cancer ceRNAs Regulatory axis |
| dc.title.none.fl_str_mv | microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Non-coding RNAs (ncRNAs) are a diverse group of functional RNA molecules that lack the ability to code for proteins. Despite missing this traditional role, ncRNAs have emerged as crucial regulators of various biological processes and have been implicated in the development and progression of many diseases, including cancer. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two prominent classes of ncRNAs that have emerged as key players in cancer pathophysiology. In particular, miR-21 has been reported to exhibit oncogenic roles in various forms of human cancer, including prostate, breast, lung, and colorectal cancer. In this context, miR-21 overexpression is closely associated with tumor proliferation, growth, invasion, angiogenesis, and chemoresistance, whereas miR-21 inactivation is linked to the regression of most tumor-related processes. Accordingly, miR-21 is a crucial modulator of various canonical oncogenic pathways such as PTEN/PI3K/Akt, Wnt/β-catenin, STAT, p53, MMP2, and MMP9. Moreover, interplays between lncRNA and miRNA further complicate the regulatory mechanisms underlying tumor development and progression. In this regard, several lncRNAs have been found to interact with miR-21 and, by functioning as competitive endogenous RNAs (ceRNAs) or miRNA sponges, can modulate cancer tumorigenesis. This work presents and discusses recent findings highlighting the roles and pathophysiological implications of the miR-21-lncRNA regulatory axis in cancer occurrence, development, and progression. The data collected indicate that specific lncRNAs, such as MEG3, CASC2, and GAS5, are strongly associated with miR-21 in various types of cancer, including gastric, cervical, lung, and glioma. Indeed, these lncRNAs are well-known tumor suppressors and are commonly downregulated in different types of tumors. Conversely, by modulating various mechanisms and oncogenic signaling pathways, their overexpression has been linked with preventing tumor formation and development. This review highlights the significance of these regulatory pathways in cancer and their potential for use in cancer therapy as diagnostic and prognostic markers. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_7ff3a12c5d0189fe5591363f53e0236e |
| identifier_str_mv | Giordo, R., Ahmadi, F. A. M., Al Husaini, N., Al-Nuaimi, N. R. A., Ahmad, S. M., Pintus, G., & Zayed, H. (2024). microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review. Non-coding RNA Research. 2468-2160 3 9 2468-0540 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/55187 |
| publishDate | 2024 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| spelling | microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative reviewRoberta, GiordoAhmadi, Fatemeh Abdullah M.Husaini, Nedal AlAl-Nuaimi, Noora Rashid A.M.Ahmad, Salma M.S.Pintus, GianfrancoZayed, HatemlncRNAsmiRNAsCancerceRNAsRegulatory axisNon-coding RNAs (ncRNAs) are a diverse group of functional RNA molecules that lack the ability to code for proteins. Despite missing this traditional role, ncRNAs have emerged as crucial regulators of various biological processes and have been implicated in the development and progression of many diseases, including cancer. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two prominent classes of ncRNAs that have emerged as key players in cancer pathophysiology. In particular, miR-21 has been reported to exhibit oncogenic roles in various forms of human cancer, including prostate, breast, lung, and colorectal cancer. In this context, miR-21 overexpression is closely associated with tumor proliferation, growth, invasion, angiogenesis, and chemoresistance, whereas miR-21 inactivation is linked to the regression of most tumor-related processes. Accordingly, miR-21 is a crucial modulator of various canonical oncogenic pathways such as PTEN/PI3K/Akt, Wnt/β-catenin, STAT, p53, MMP2, and MMP9. Moreover, interplays between lncRNA and miRNA further complicate the regulatory mechanisms underlying tumor development and progression. In this regard, several lncRNAs have been found to interact with miR-21 and, by functioning as competitive endogenous RNAs (ceRNAs) or miRNA sponges, can modulate cancer tumorigenesis. This work presents and discusses recent findings highlighting the roles and pathophysiological implications of the miR-21-lncRNA regulatory axis in cancer occurrence, development, and progression. The data collected indicate that specific lncRNAs, such as MEG3, CASC2, and GAS5, are strongly associated with miR-21 in various types of cancer, including gastric, cervical, lung, and glioma. Indeed, these lncRNAs are well-known tumor suppressors and are commonly downregulated in different types of tumors. Conversely, by modulating various mechanisms and oncogenic signaling pathways, their overexpression has been linked with preventing tumor formation and development. This review highlights the significance of these regulatory pathways in cancer and their potential for use in cancer therapy as diagnostic and prognostic markers.This work was made possible by grants from \u201CProgetto Fondazione di Sardegna -Bando 2022\u20132023\u201D and \u201C, European Union\u2014 NextGenerationEU - DM 737/2021 resources 2021\u20132022\u201D.Elsevier2024-05-20T08:16:08Z2024-03-31Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.ncrna.2024.03.013Giordo, R., Ahmadi, F. A. M., Al Husaini, N., Al-Nuaimi, N. R. A., Ahmad, S. M., Pintus, G., & Zayed, H. (2024). microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review. Non-coding RNA Research.2468-2160https://www.sciencedirect.com/science/article/pii/S2468054024000817http://hdl.handle.net/10576/55187392468-0540enhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/551872024-07-23T15:53:46Z |
| spellingShingle | microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review Roberta, Giordo lncRNAs miRNAs Cancer ceRNAs Regulatory axis |
| status_str | publishedVersion |
| title | microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review |
| title_full | microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review |
| title_fullStr | microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review |
| title_full_unstemmed | microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review |
| title_short | microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review |
| title_sort | microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review |
| topic | lncRNAs miRNAs Cancer ceRNAs Regulatory axis |
| url | http://dx.doi.org/10.1016/j.ncrna.2024.03.013 https://www.sciencedirect.com/science/article/pii/S2468054024000817 http://hdl.handle.net/10576/55187 |