The potential role of vitamin C in empowering cancer immunotherapy
Vitamin C also known as L-ascorbic acid is a nutrient naturally occurring in many fruits and vegetables and widely known for its potent antioxidant activity. Several studies have highlighted the importance of using high dose vitamin C as an adjuvant anti-cancer therapy. Interestingly, it has been sh...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , , |
| التنسيق: | article |
| منشور في: |
2022
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.biopha.2021.112553 https://www.sciencedirect.com/science/article/pii/S0753332221013408 http://hdl.handle.net/10576/38842 |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1857415084470435840 |
|---|---|
| author | Takwa, Bedhiafi |
| author2 | Inchakalody, Varghese Philipose Fernandes, Queenie Mestiri, Sarra Billa, Nashiru Uddin, Shahab Merhi, Maysaloun Dermime, Said |
| author2_role | author author author author author author author |
| author_facet | Takwa, Bedhiafi Inchakalody, Varghese Philipose Fernandes, Queenie Mestiri, Sarra Billa, Nashiru Uddin, Shahab Merhi, Maysaloun Dermime, Said |
| author_role | author |
| dc.creator.none.fl_str_mv | Takwa, Bedhiafi Inchakalody, Varghese Philipose Fernandes, Queenie Mestiri, Sarra Billa, Nashiru Uddin, Shahab Merhi, Maysaloun Dermime, Said |
| dc.date.none.fl_str_mv | 2022-02-28 2023-01-25T06:30:07Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.biopha.2021.112553 Bedhiafi, T., Inchakalody, V. P., Fernandes, Q., Mestiri, S., Billa, N., Uddin, S., ... & Dermime, S. (2022). The potential role of vitamin C in empowering cancer immunotherapy. Biomedicine & Pharmacotherapy, 146, 112553. 07533322 https://www.sciencedirect.com/science/article/pii/S0753332221013408 http://hdl.handle.net/10576/38842 146 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Vitamin C Immune checkpoint blockade Immunotherapy Cancer therapy |
| dc.title.none.fl_str_mv | The potential role of vitamin C in empowering cancer immunotherapy |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Vitamin C also known as L-ascorbic acid is a nutrient naturally occurring in many fruits and vegetables and widely known for its potent antioxidant activity. Several studies have highlighted the importance of using high dose vitamin C as an adjuvant anti-cancer therapy. Interestingly, it has been shown that vitamin C is able to modulate the anti-cancer immune response and to help to overcome the resistance to immune checkpoints blockade (ICB) drugs such as cytotoxic T-lymphocyte antigen 4 (CLTA-4) and programmed cell death ligand 1 (PD-L1/PD-1) inhibitors. Indeed, it was reported that vitamin C regulates several mechanisms developed by cancer cells to escape T cells immune response and resist ICB. Understanding the role of vitamin C in the anti-tumor immune response will pave the way to the development of novel combination therapies that would enhance the response of cancer patients to ICB immunotherapy. In this review, we discuss the effect of vitamin C on the immune system and its potential role in empowering cancer immunotherapy through its pro-oxidant potential, its ability to modulate epigenetic factors and its capacity to regulate the expression of different cytokines involved in the immune response. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_82ca4680265cf978d756d42b135138f5 |
| identifier_str_mv | Bedhiafi, T., Inchakalody, V. P., Fernandes, Q., Mestiri, S., Billa, N., Uddin, S., ... & Dermime, S. (2022). The potential role of vitamin C in empowering cancer immunotherapy. Biomedicine & Pharmacotherapy, 146, 112553. 07533322 146 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/38842 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | The potential role of vitamin C in empowering cancer immunotherapyTakwa, BedhiafiInchakalody, Varghese PhiliposeFernandes, QueenieMestiri, SarraBilla, NashiruUddin, ShahabMerhi, MaysalounDermime, SaidVitamin CImmune checkpoint blockadeImmunotherapyCancer therapyVitamin C also known as L-ascorbic acid is a nutrient naturally occurring in many fruits and vegetables and widely known for its potent antioxidant activity. Several studies have highlighted the importance of using high dose vitamin C as an adjuvant anti-cancer therapy. Interestingly, it has been shown that vitamin C is able to modulate the anti-cancer immune response and to help to overcome the resistance to immune checkpoints blockade (ICB) drugs such as cytotoxic T-lymphocyte antigen 4 (CLTA-4) and programmed cell death ligand 1 (PD-L1/PD-1) inhibitors. Indeed, it was reported that vitamin C regulates several mechanisms developed by cancer cells to escape T cells immune response and resist ICB. Understanding the role of vitamin C in the anti-tumor immune response will pave the way to the development of novel combination therapies that would enhance the response of cancer patients to ICB immunotherapy. In this review, we discuss the effect of vitamin C on the immune system and its potential role in empowering cancer immunotherapy through its pro-oxidant potential, its ability to modulate epigenetic factors and its capacity to regulate the expression of different cytokines involved in the immune response.Open Access funding provided by the Qatar National Library.Elsevier2023-01-25T06:30:07Z2022-02-28Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.biopha.2021.112553Bedhiafi, T., Inchakalody, V. P., Fernandes, Q., Mestiri, S., Billa, N., Uddin, S., ... & Dermime, S. (2022). The potential role of vitamin C in empowering cancer immunotherapy. Biomedicine & Pharmacotherapy, 146, 112553.07533322https://www.sciencedirect.com/science/article/pii/S0753332221013408http://hdl.handle.net/10576/38842146enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/388422024-07-23T13:52:15Z |
| spellingShingle | The potential role of vitamin C in empowering cancer immunotherapy Takwa, Bedhiafi Vitamin C Immune checkpoint blockade Immunotherapy Cancer therapy |
| status_str | publishedVersion |
| title | The potential role of vitamin C in empowering cancer immunotherapy |
| title_full | The potential role of vitamin C in empowering cancer immunotherapy |
| title_fullStr | The potential role of vitamin C in empowering cancer immunotherapy |
| title_full_unstemmed | The potential role of vitamin C in empowering cancer immunotherapy |
| title_short | The potential role of vitamin C in empowering cancer immunotherapy |
| title_sort | The potential role of vitamin C in empowering cancer immunotherapy |
| topic | Vitamin C Immune checkpoint blockade Immunotherapy Cancer therapy |
| url | http://dx.doi.org/10.1016/j.biopha.2021.112553 https://www.sciencedirect.com/science/article/pii/S0753332221013408 http://hdl.handle.net/10576/38842 |