TERT gene fusions characterize a subset of metastatic Leydig cell tumors

TERT gene fusions characterize a subset of metastatic Leydig cell tumors

Objective: Metastatic Leydig cell tumors (LCT) are rare, difficult to treat malignancies without known underlying molecular-genetic events. An index case of metastatic LCT showed an LDLR-TERT gene fusion upon routine genetic profiling for detection of therapeutic targets, which was then followed by...

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Bibliographic Details
Main Author: Bozo, Kruslin (author)
Other Authors: Gatalica, Zoran (author), Hes, Ondrej (author), Skenderi, Faruk (author), Miettinen, Markku (author), Contreras, Elma (author), Xiu, Joanne (author), Elis, Michelle (author), Florento, Elena (author), Vranic, Semir (author), Swensen, Jeffrey (author)
Format: article
Published: 2021
Subjects:
Sex cord–stromal tumors
Leydig cell tumor
molecular profiling
sequencing
targeted therapy
Online Access:http://dx.doi.org/10.1016/j.clgc.2021.02.002
https://www.sciencedirect.com/science/article/pii/S155876732100046X?v=s5
http://hdl.handle.net/10576/17834
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