SARS-CoV-2 Infection and Smoking: What is the association? A brief review
Susceptibility to severe illness from COVID-19 is anticipated to be associated with cigarette smoking as it aggravates the risk of cardiovascular and respiratory illness, including infections. This is particularly important with the advent of a new strain of coronaviruses, the severe acute respirato...
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2021
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| Online Access: | http://dx.doi.org/10.1016/j.csbj.2021.03.023 https://www.sciencedirect.com/science/article/pii/S2001037021000957?v=s5 http://hdl.handle.net/10576/18031 |
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| _version_ | 1857415085261062144 |
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| author | Ishita, Gupta |
| author2 | Sohail, Muhammad Umar Elzawawi, Khaled E. Amarah, Ahmed H. Vranic, Semir Al-Asmakh, Maha Moustafa, Ala-Eddin Al |
| author2_role | author author author author author author |
| author_facet | Ishita, Gupta Sohail, Muhammad Umar Elzawawi, Khaled E. Amarah, Ahmed H. Vranic, Semir Al-Asmakh, Maha Moustafa, Ala-Eddin Al |
| author_role | author |
| dc.creator.none.fl_str_mv | Ishita, Gupta Sohail, Muhammad Umar Elzawawi, Khaled E. Amarah, Ahmed H. Vranic, Semir Al-Asmakh, Maha Moustafa, Ala-Eddin Al |
| dc.date.none.fl_str_mv | 2021-03-29T10:08:43Z 2021-03-23 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.csbj.2021.03.023 Gupta, I., Sohail, M. U., Elzawawi, K. E., Amarah, A. H., Vranic, S., Al-Asmakh, M., & Al Moustafa, A. E. (2021). SARS-CoV-2 Infection and Smoking: What is the association? A brief review. Computational and Structural Biotechnology Journal. 20010370 https://www.sciencedirect.com/science/article/pii/S2001037021000957?v=s5 http://hdl.handle.net/10576/18031 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | SARS-CoV-2 Coronavirus COVID-19 Smoking Lung Disease Oral Disease |
| dc.title.none.fl_str_mv | SARS-CoV-2 Infection and Smoking: What is the association? A brief review |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Susceptibility to severe illness from COVID-19 is anticipated to be associated with cigarette smoking as it aggravates the risk of cardiovascular and respiratory illness, including infections. This is particularly important with the advent of a new strain of coronaviruses, the severe acute respiratory syndrome coronavirus (SARS-CoV-2) that has led to the present pandemic, coronavirus disease 2019 (COVID-19). Although, the effects of smoking on COVID-19 are less described and controversial, we presume a link between smoking and COVID-19. Smoking has been shown to enhance the expression of the angiotensin-converting enzyme-2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) key entry genes utilized by SARS-CoV-2 to infect cells and induce a ‘cytokine storm’, which further increases the severity of COVID-19 clinical course. Nevertheless, the impact of smoking on ACE-2 and TMPRSS2 receptors expression remains paradoxical. Thus, further research is necessary to unravel the association between smoking and COVID-19 and to pursue the development of potential novel therapies that are able to constrain the morbidity and mortality provoked by this infectious disease. Herein we present a brief overview of the current knowledge on the correlation between smoking and the expression of SARS-CoV-2 key entry genes, clinical manifestations, and disease progression. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_8a959648c6004aa51baf7296656a95bb |
| identifier_str_mv | Gupta, I., Sohail, M. U., Elzawawi, K. E., Amarah, A. H., Vranic, S., Al-Asmakh, M., & Al Moustafa, A. E. (2021). SARS-CoV-2 Infection and Smoking: What is the association? A brief review. Computational and Structural Biotechnology Journal. 20010370 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/18031 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | SARS-CoV-2 Infection and Smoking: What is the association? A brief reviewIshita, GuptaSohail, Muhammad UmarElzawawi, Khaled E.Amarah, Ahmed H.Vranic, SemirAl-Asmakh, MahaMoustafa, Ala-Eddin AlSARS-CoV-2CoronavirusCOVID-19SmokingLung DiseaseOral DiseaseSusceptibility to severe illness from COVID-19 is anticipated to be associated with cigarette smoking as it aggravates the risk of cardiovascular and respiratory illness, including infections. This is particularly important with the advent of a new strain of coronaviruses, the severe acute respiratory syndrome coronavirus (SARS-CoV-2) that has led to the present pandemic, coronavirus disease 2019 (COVID-19). Although, the effects of smoking on COVID-19 are less described and controversial, we presume a link between smoking and COVID-19. Smoking has been shown to enhance the expression of the angiotensin-converting enzyme-2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) key entry genes utilized by SARS-CoV-2 to infect cells and induce a ‘cytokine storm’, which further increases the severity of COVID-19 clinical course. Nevertheless, the impact of smoking on ACE-2 and TMPRSS2 receptors expression remains paradoxical. Thus, further research is necessary to unravel the association between smoking and COVID-19 and to pursue the development of potential novel therapies that are able to constrain the morbidity and mortality provoked by this infectious disease. Herein we present a brief overview of the current knowledge on the correlation between smoking and the expression of SARS-CoV-2 key entry genes, clinical manifestations, and disease progression.Elsevier2021-03-29T10:08:43Z2021-03-23Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.csbj.2021.03.023Gupta, I., Sohail, M. U., Elzawawi, K. E., Amarah, A. H., Vranic, S., Al-Asmakh, M., & Al Moustafa, A. E. (2021). SARS-CoV-2 Infection and Smoking: What is the association? A brief review. Computational and Structural Biotechnology Journal.20010370https://www.sciencedirect.com/science/article/pii/S2001037021000957?v=s5http://hdl.handle.net/10576/18031enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/180312024-07-23T11:23:32Z |
| spellingShingle | SARS-CoV-2 Infection and Smoking: What is the association? A brief review Ishita, Gupta SARS-CoV-2 Coronavirus COVID-19 Smoking Lung Disease Oral Disease |
| status_str | publishedVersion |
| title | SARS-CoV-2 Infection and Smoking: What is the association? A brief review |
| title_full | SARS-CoV-2 Infection and Smoking: What is the association? A brief review |
| title_fullStr | SARS-CoV-2 Infection and Smoking: What is the association? A brief review |
| title_full_unstemmed | SARS-CoV-2 Infection and Smoking: What is the association? A brief review |
| title_short | SARS-CoV-2 Infection and Smoking: What is the association? A brief review |
| title_sort | SARS-CoV-2 Infection and Smoking: What is the association? A brief review |
| topic | SARS-CoV-2 Coronavirus COVID-19 Smoking Lung Disease Oral Disease |
| url | http://dx.doi.org/10.1016/j.csbj.2021.03.023 https://www.sciencedirect.com/science/article/pii/S2001037021000957?v=s5 http://hdl.handle.net/10576/18031 |