Life-threatening arrhythmogenic CaM mutations disrupt CaM binding to a distinct RyR2 CaM-binding pocket
Calmodulin (CaM) modulates the activity of several proteins that play a key role in excitation-contraction coupling (ECC). In cardiac muscle, the major binding partner of CaM is the type-2 ryanodine receptor (RyR2) and altered CaM binding contributes to defects in sarcoplasmic reticulum (SR) calcium...
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| Other Authors: | , , , , , , , , , |
| Format: | article |
| Published: |
2023
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| Online Access: | http://dx.doi.org/10.1016/j.bbagen.2023.130313 https://www.sciencedirect.com/science/article/pii/S0304416523000119 http://hdl.handle.net/10576/39329 |
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