Anti-hypertrophic effect of Na+/H+ exchanger-1 inhibition is mediated by reduced cathepsin B

Previous studies have established the role of Na+/H+ exchanger isoform-1 (NHE1) and cathepsin B (Cat B) in the development of cardiomyocyte hypertrophy (CH). Both NHE1 and Cat B are activated under acidic conditions suggesting that their activities might be interrelated. The inhibition of NHE1 has b...

وصف كامل

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Sadaf, Riaz (author)
مؤلفون آخرون:	Abdulrahman, Nabeel (author), Uddin, Shahab (author), Jabeen, Ayesha (author), Gadeau, Alain P. (author), Fliegel, Larry (author), Mraiche, Fatima (author)
التنسيق:	article
منشور في:	2020
الموضوعات:	Cardiomyocytes Hypertrophy Autophagy Cathepsins Angiotensin Matrix metalloproteinases
الوصول للمادة أونلاين:	http://dx.doi.org/10.1016/j.ejphar.2020.173420 https://www.sciencedirect.com/science/article/pii/S0014299920305124 http://hdl.handle.net/10576/44612
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Anti-hypertrophic effect of Na+/H+ exchanger-1 inhibition is mediated by reduced cathepsin B

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