Anti-hypertrophic effect of Na+/H+ exchanger-1 inhibition is mediated by reduced cathepsin B

Anti-hypertrophic effect of Na+/H+ exchanger-1 inhibition is mediated by reduced cathepsin B

Previous studies have established the role of Na+/H+ exchanger isoform-1 (NHE1) and cathepsin B (Cat B) in the development of cardiomyocyte hypertrophy (CH). Both NHE1 and Cat B are activated under acidic conditions suggesting that their activities might be interrelated. The inhibition of NHE1 has b...

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Bibliographic Details
Main Author: Sadaf, Riaz (author)
Other Authors: Abdulrahman, Nabeel (author), Uddin, Shahab (author), Jabeen, Ayesha (author), Gadeau, Alain P. (author), Fliegel, Larry (author), Mraiche, Fatima (author)
Format: article
Published: 2020
Subjects:
Cardiomyocytes
Hypertrophy
Autophagy
Cathepsins
Angiotensin
Matrix metalloproteinases
Online Access:http://dx.doi.org/10.1016/j.ejphar.2020.173420
https://www.sciencedirect.com/science/article/pii/S0014299920305124
http://hdl.handle.net/10576/44612
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http://dx.doi.org/10.1016/j.ejphar.2020.173420
https://www.sciencedirect.com/science/article/pii/S0014299920305124
http://hdl.handle.net/10576/44612

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