Many meta-analyses of rare events in the Cochrane Database of Systematic Reviews were underpowered
Background and ObjectiveMeta-analysis is a statistical method with the ability to increase the power for statistical inference, while it may still face the problem of being underpowered. In this study, we investigated the power to detect certain true effects for published meta-analyses of rare event...
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2021
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.jclinepi.2020.11.017 https://www.sciencedirect.com/science/article/pii/S0895435620311884 http://hdl.handle.net/10576/17559 |
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| _version_ | 1857415087571075072 |
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| author | Pengli, Jia |
| author2 | Lin, Lifeng Kwong, Joey S W Xu, Chang |
| author2_role | author author author |
| author_facet | Pengli, Jia Lin, Lifeng Kwong, Joey S W Xu, Chang |
| author_role | author |
| dc.creator.none.fl_str_mv | Pengli, Jia Lin, Lifeng Kwong, Joey S W Xu, Chang |
| dc.date.none.fl_str_mv | 2021-02-07T09:27:29Z 2021-03-31 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.jclinepi.2020.11.017 08954356 https://www.sciencedirect.com/science/article/pii/S0895435620311884 http://hdl.handle.net/10576/17559 113-122 131 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Meta-analysis of rare events Power analysis Cochrane systematic reviews Statistical inference Decision-making Relative risk redcution |
| dc.title.none.fl_str_mv | Many meta-analyses of rare events in the Cochrane Database of Systematic Reviews were underpowered |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background and ObjectiveMeta-analysis is a statistical method with the ability to increase the power for statistical inference, while it may still face the problem of being underpowered. In this study, we investigated the power to detect certain true effects for published meta-analyses of rare events. MethodsWe extracted data from the Cochrane Database of Systematic Reviews for meta-analyses of rare events from January 2003 to May 2018. We retrospectively estimated the power to detect a 10–50% relative risk reduction (RRR) of eligible meta-analyses. The proportion of meta-analyses achieved a sufficient power (≥0.8) were estimated. ResultsWe identified 4,177 meta-analyses. The median power to detect 10%, 30%, and 50% RRR were 0.06 (interquartile range [IQR]: 0.05 to 0.06), 0.08 (IQR: 0.06 to 0.15), and 0.17 (IQR: 0.10 to 0.42), respectively); the corresponding proportion of meta-analyses that reached sufficient power were 0.32%, 3.68%, and 11.81%. Meta-analyses incorporating data from more studies had higher probability to achieve a sufficient power (rate ratio = 2.49, 95% CI: 1.76, 3.52, P < 0.001). ConclusionMost of the meta-analyses of rare events in Cochrane systematic reviews were underpowered. Future meta-analysis of rare events should report the power of the results to support informative conclusions. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_8f11787191dcdc0d98558bccd57a58c6 |
| identifier_str_mv | 08954356 113-122 131 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/17559 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Many meta-analyses of rare events in the Cochrane Database of Systematic Reviews were underpoweredPengli, JiaLin, LifengKwong, Joey S WXu, ChangMeta-analysis of rare eventsPower analysisCochrane systematic reviewsStatistical inferenceDecision-makingRelative risk redcutionBackground and ObjectiveMeta-analysis is a statistical method with the ability to increase the power for statistical inference, while it may still face the problem of being underpowered. In this study, we investigated the power to detect certain true effects for published meta-analyses of rare events. MethodsWe extracted data from the Cochrane Database of Systematic Reviews for meta-analyses of rare events from January 2003 to May 2018. We retrospectively estimated the power to detect a 10–50% relative risk reduction (RRR) of eligible meta-analyses. The proportion of meta-analyses achieved a sufficient power (≥0.8) were estimated. ResultsWe identified 4,177 meta-analyses. The median power to detect 10%, 30%, and 50% RRR were 0.06 (interquartile range [IQR]: 0.05 to 0.06), 0.08 (IQR: 0.06 to 0.15), and 0.17 (IQR: 0.10 to 0.42), respectively); the corresponding proportion of meta-analyses that reached sufficient power were 0.32%, 3.68%, and 11.81%. Meta-analyses incorporating data from more studies had higher probability to achieve a sufficient power (rate ratio = 2.49, 95% CI: 1.76, 3.52, P < 0.001). ConclusionMost of the meta-analyses of rare events in Cochrane systematic reviews were underpowered. Future meta-analysis of rare events should report the power of the results to support informative conclusions.We would like to thank Qatar National Library for funding the Open Access payment.Elsevier2021-02-07T09:27:29Z2021-03-31Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.jclinepi.2020.11.01708954356https://www.sciencedirect.com/science/article/pii/S0895435620311884http://hdl.handle.net/10576/17559113-122131enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/175592024-07-23T11:23:19Z |
| spellingShingle | Many meta-analyses of rare events in the Cochrane Database of Systematic Reviews were underpowered Pengli, Jia Meta-analysis of rare events Power analysis Cochrane systematic reviews Statistical inference Decision-making Relative risk redcution |
| status_str | publishedVersion |
| title | Many meta-analyses of rare events in the Cochrane Database of Systematic Reviews were underpowered |
| title_full | Many meta-analyses of rare events in the Cochrane Database of Systematic Reviews were underpowered |
| title_fullStr | Many meta-analyses of rare events in the Cochrane Database of Systematic Reviews were underpowered |
| title_full_unstemmed | Many meta-analyses of rare events in the Cochrane Database of Systematic Reviews were underpowered |
| title_short | Many meta-analyses of rare events in the Cochrane Database of Systematic Reviews were underpowered |
| title_sort | Many meta-analyses of rare events in the Cochrane Database of Systematic Reviews were underpowered |
| topic | Meta-analysis of rare events Power analysis Cochrane systematic reviews Statistical inference Decision-making Relative risk redcution |
| url | http://dx.doi.org/10.1016/j.jclinepi.2020.11.017 https://www.sciencedirect.com/science/article/pii/S0895435620311884 http://hdl.handle.net/10576/17559 |