Molecular profiling of the metaplastic spindle cell carcinoma of the breast reveals potentially targetable biomarkers

Molecular profiling of the metaplastic spindle cell carcinoma of the breast reveals potentially targetable biomarkers

IntroductionSpindle cell carcinoma is a rare subtype of metaplastic breast cancer (MBC), with triple-negative (TNBC: ER-/PR-/Her2-) phenotype. It is associated with a marked resistance to conventional chemotherapy and has overall poor outcome. Materials and MethodsTwenty-three pure spindle cell carc...

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Bibliographic Details
Main Author: Semir, Vranic (author)
Other Authors: Stafford, Phillip (author), Palazzo, Juan (author), Skenderi, Faruk (author), Swensen, Jeffrey (author), Xiu, Joanne (author), Spetzler, David (author), Gatalica, Zoran (author)
Format: article
Published: 2020
Subjects:
Breast cancer
metaplastic carcinoma
spindle cell carcinoma
molecular profiling
immune checkpoint inhibitors
targeted therapy
mutations
Online Access:http://dx.doi.org/10.1016/j.clbc.2020.02.008
https://www.sciencedirect.com/science/article/pii/S1526820920300434?v=s5
http://hdl.handle.net/10576/13273
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