The role of genetic and epigenetic GNAS alterations in the development of early-onset obesity

The role of genetic and epigenetic GNAS alterations in the development of early-onset obesity

BackgroundGNAS (guanine nucleotide-binding protein, alpha stimulating) is an imprinted gene that encodes Gsα, the α subunit of the heterotrimeric stimulatory G protein. This subunit mediates the signalling of a diverse array of G protein-coupled receptors (GPCRs), including the melanocortin 4 recept...

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Bibliographic Details
Main Author: Alaa, Abbas (author)
Other Authors: Hammad, Ayat S (author), Al-Shafai, Mashael (author)
Format: article
Published: 2023
Subjects:
Early-onset obesity
Stimulatory G protein alpha subunit
Molecular mechanisms
Mutations
Methylation defects
Online Access:http://dx.doi.org/10.1016/j.mrrev.2023.108487
https://www.sciencedirect.com/science/article/pii/S1383574223000352
http://hdl.handle.net/10576/53084
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http://dx.doi.org/10.1016/j.mrrev.2023.108487
https://www.sciencedirect.com/science/article/pii/S1383574223000352
http://hdl.handle.net/10576/53084

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