Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity
Obesity is a global burden and a chronic ailment with damaging overall health effects. Ghrelin, an octanoylated 28 amino acid peptide hormone, is secreted from the oxyntic mucosa of the stomach. Ghrelin acts on regions of the hypothalamus to regulate feeding behavior and glucose homeostasis through...
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2021
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| Online Access: | http://dx.doi.org/10.1016/j.cellsig.2021.109976 https://www.sciencedirect.com/science/article/pii/S0898656821000644 http://hdl.handle.net/10576/17969 |
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| _version_ | 1857415085808418816 |
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| author | Karim, Nagi |
| author2 | Habib, Abdella M. |
| author2_role | author |
| author_facet | Karim, Nagi Habib, Abdella M. |
| author_role | author |
| dc.creator.none.fl_str_mv | Karim, Nagi Habib, Abdella M. |
| dc.date.none.fl_str_mv | 2021-03-25T06:31:16Z 2021-07-31 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.cellsig.2021.109976 Nagi K, Habib AM. Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity. Cell Signal. 2021 Mar 10;83:109976. doi: 10.1016/j.cellsig.2021.109976. 08986568 https://www.sciencedirect.com/science/article/pii/S0898656821000644 http://hdl.handle.net/10576/17969 83 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Bias Ghrelin Biased agonism Obesity Dimer Functional selectivity |
| dc.title.none.fl_str_mv | Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Obesity is a global burden and a chronic ailment with damaging overall health effects. Ghrelin, an octanoylated 28 amino acid peptide hormone, is secreted from the oxyntic mucosa of the stomach. Ghrelin acts on regions of the hypothalamus to regulate feeding behavior and glucose homeostasis through its G protein-coupled receptor. Recently, several central pathways modulating the metabolic actions of ghrelin have been reported. While these signaling pathways can be inhibited or activated by antagonists or agonists, they can also be discriminatingly activated in a “biased” response to impart different degrees of activation in distinct pathways downstream of the receptor. Here, we review recent ghrelin biased signaling findings as well as characteristics of ghrelin hormone and its receptors pertinent for biased signaling. We then evaluate the feasibility for ghrelin receptor biased signaling as a strategy for the development of effective pharmacotherapy in obesity treatment. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_93a5751d4cd7f78d0837f690c7e1c8cc |
| identifier_str_mv | Nagi K, Habib AM. Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity. Cell Signal. 2021 Mar 10;83:109976. doi: 10.1016/j.cellsig.2021.109976. 08986568 83 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/17969 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesityKarim, NagiHabib, Abdella M.BiasGhrelinBiased agonismObesityDimerFunctional selectivityObesity is a global burden and a chronic ailment with damaging overall health effects. Ghrelin, an octanoylated 28 amino acid peptide hormone, is secreted from the oxyntic mucosa of the stomach. Ghrelin acts on regions of the hypothalamus to regulate feeding behavior and glucose homeostasis through its G protein-coupled receptor. Recently, several central pathways modulating the metabolic actions of ghrelin have been reported. While these signaling pathways can be inhibited or activated by antagonists or agonists, they can also be discriminatingly activated in a “biased” response to impart different degrees of activation in distinct pathways downstream of the receptor. Here, we review recent ghrelin biased signaling findings as well as characteristics of ghrelin hormone and its receptors pertinent for biased signaling. We then evaluate the feasibility for ghrelin receptor biased signaling as a strategy for the development of effective pharmacotherapy in obesity treatment.Elsevier2021-03-25T06:31:16Z2021-07-31Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.cellsig.2021.109976Nagi K, Habib AM. Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity. Cell Signal. 2021 Mar 10;83:109976. doi: 10.1016/j.cellsig.2021.109976.08986568https://www.sciencedirect.com/science/article/pii/S0898656821000644http://hdl.handle.net/10576/1796983enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/179692024-07-23T11:23:31Z |
| spellingShingle | Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity Karim, Nagi Bias Ghrelin Biased agonism Obesity Dimer Functional selectivity |
| status_str | publishedVersion |
| title | Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity |
| title_full | Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity |
| title_fullStr | Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity |
| title_full_unstemmed | Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity |
| title_short | Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity |
| title_sort | Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity |
| topic | Bias Ghrelin Biased agonism Obesity Dimer Functional selectivity |
| url | http://dx.doi.org/10.1016/j.cellsig.2021.109976 https://www.sciencedirect.com/science/article/pii/S0898656821000644 http://hdl.handle.net/10576/17969 |