The predictors of perforated appendicitis in the pediatric emergency department: A retrospective observational cohort study
Objective Appendiceal perforation has significant effects on perioperative morbidity and postoperative outcome. The present study aimed to identify possible predictive factors associated with perforated appendicitis (PA) in children at admission in the emergency department (ED). Methods In this retr...
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| مؤلفون آخرون: | , , , , , |
| التنسيق: | article |
| منشور في: |
2021
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.ajem.2021.06.028 https://www.sciencedirect.com/science/article/pii/S073567572100512X http://hdl.handle.net/10576/20824 |
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| _version_ | 1857415090280595456 |
|---|---|
| author | Zlatan, Zvizdic |
| author2 | Golos, Alisa Duric Milisic, Emir Jonuzi, Asmir Zvizdic, Denisa Glamoclija, Una Vranic, Semir |
| author2_role | author author author author author author |
| author_facet | Zlatan, Zvizdic Golos, Alisa Duric Milisic, Emir Jonuzi, Asmir Zvizdic, Denisa Glamoclija, Una Vranic, Semir |
| author_role | author |
| dc.creator.none.fl_str_mv | Zlatan, Zvizdic Golos, Alisa Duric Milisic, Emir Jonuzi, Asmir Zvizdic, Denisa Glamoclija, Una Vranic, Semir |
| dc.date.none.fl_str_mv | 2021-06-23T05:59:23Z 2021-11-30 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.ajem.2021.06.028 Zvizdic, Z., Golos, A. D., Milisic, E., Jonuzi, A., Zvizdic, D., Glamoclija, U., & Vranic, S. (2021). The predictors of perforated appendicitis in the pediatric emergency department: A retrospective observational cohort study. The American Journal of Emergency Medicine. 07356757 https://www.sciencedirect.com/science/article/pii/S073567572100512X http://hdl.handle.net/10576/20824 49 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Perforated appendicitis Predictive factors Children |
| dc.title.none.fl_str_mv | The predictors of perforated appendicitis in the pediatric emergency department: A retrospective observational cohort study |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Objective Appendiceal perforation has significant effects on perioperative morbidity and postoperative outcome. The present study aimed to identify possible predictive factors associated with perforated appendicitis (PA) in children at admission in the emergency department (ED). Methods In this retrospective observational cohort study, consecutive medical records of children <18 years old with surgically and histopathologically confirmed acute appendicitis (AA) over three years (2013–2015) were analyzed. Patients were divided into two groups: PA and non-perforated appendicitis (NPA). The differences between the two groups and potential predictors of PA were explored using univariate and multivariate analyses. Results During the study period, 295 patients underwent an appendectomy and had confirmatory AA diagnoses. Ninety-two patients had a PA (31.2%). In the univariate analysis, male gender, vomiting, diarrhea, fever, elevated white blood cell count (WBC) levels, and high C-reactive protein (CRP) were identified as predictors of PA. In the multivariate analysis, male gender (odds ratio [OR]: 3.133; 95% confidence interval [CI]: 1.610–6.096); vomiting (OR: 2.346; 95% CI: 1.141–4.822); diarrhea (OR: 4.549; 95% CI: 1.850–11.181); fever (OR: 3.429; 95% CI: 1.765–6.663); elevated WBC (OR: 2.962; 95% CI: 1.491–5.884) and elevated CRP (OR: 3.061; 95% CI: 1.267–7.396) were variables that predicted the PA in children. Conclusion Our data indicate that several clinical and biochemical parameters can reliably distinguish between pediatric PA and NPA at admission in the emergency department. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_9718527f0af285476c4c3eb2ed5d0a2e |
| identifier_str_mv | Zvizdic, Z., Golos, A. D., Milisic, E., Jonuzi, A., Zvizdic, D., Glamoclija, U., & Vranic, S. (2021). The predictors of perforated appendicitis in the pediatric emergency department: A retrospective observational cohort study. The American Journal of Emergency Medicine. 07356757 49 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/20824 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | The predictors of perforated appendicitis in the pediatric emergency department: A retrospective observational cohort studyZlatan, ZvizdicGolos, Alisa DuricMilisic, EmirJonuzi, AsmirZvizdic, DenisaGlamoclija, UnaVranic, SemirPerforated appendicitisPredictive factorsChildrenObjective Appendiceal perforation has significant effects on perioperative morbidity and postoperative outcome. The present study aimed to identify possible predictive factors associated with perforated appendicitis (PA) in children at admission in the emergency department (ED). Methods In this retrospective observational cohort study, consecutive medical records of children <18 years old with surgically and histopathologically confirmed acute appendicitis (AA) over three years (2013–2015) were analyzed. Patients were divided into two groups: PA and non-perforated appendicitis (NPA). The differences between the two groups and potential predictors of PA were explored using univariate and multivariate analyses. Results During the study period, 295 patients underwent an appendectomy and had confirmatory AA diagnoses. Ninety-two patients had a PA (31.2%). In the univariate analysis, male gender, vomiting, diarrhea, fever, elevated white blood cell count (WBC) levels, and high C-reactive protein (CRP) were identified as predictors of PA. In the multivariate analysis, male gender (odds ratio [OR]: 3.133; 95% confidence interval [CI]: 1.610–6.096); vomiting (OR: 2.346; 95% CI: 1.141–4.822); diarrhea (OR: 4.549; 95% CI: 1.850–11.181); fever (OR: 3.429; 95% CI: 1.765–6.663); elevated WBC (OR: 2.962; 95% CI: 1.491–5.884) and elevated CRP (OR: 3.061; 95% CI: 1.267–7.396) were variables that predicted the PA in children. Conclusion Our data indicate that several clinical and biochemical parameters can reliably distinguish between pediatric PA and NPA at admission in the emergency department.Qatar National Library funded the open access publication of this article.Elsevier2021-06-23T05:59:23Z2021-11-30Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.ajem.2021.06.028Zvizdic, Z., Golos, A. D., Milisic, E., Jonuzi, A., Zvizdic, D., Glamoclija, U., & Vranic, S. (2021). The predictors of perforated appendicitis in the pediatric emergency department: A retrospective observational cohort study. The American Journal of Emergency Medicine.07356757https://www.sciencedirect.com/science/article/pii/S073567572100512Xhttp://hdl.handle.net/10576/2082449enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/208242024-07-23T11:23:46Z |
| spellingShingle | The predictors of perforated appendicitis in the pediatric emergency department: A retrospective observational cohort study Zlatan, Zvizdic Perforated appendicitis Predictive factors Children |
| status_str | publishedVersion |
| title | The predictors of perforated appendicitis in the pediatric emergency department: A retrospective observational cohort study |
| title_full | The predictors of perforated appendicitis in the pediatric emergency department: A retrospective observational cohort study |
| title_fullStr | The predictors of perforated appendicitis in the pediatric emergency department: A retrospective observational cohort study |
| title_full_unstemmed | The predictors of perforated appendicitis in the pediatric emergency department: A retrospective observational cohort study |
| title_short | The predictors of perforated appendicitis in the pediatric emergency department: A retrospective observational cohort study |
| title_sort | The predictors of perforated appendicitis in the pediatric emergency department: A retrospective observational cohort study |
| topic | Perforated appendicitis Predictive factors Children |
| url | http://dx.doi.org/10.1016/j.ajem.2021.06.028 https://www.sciencedirect.com/science/article/pii/S073567572100512X http://hdl.handle.net/10576/20824 |