SARS-CoV-2 and immune-microbiome interactions: Lessons from respiratory viral infections
By the beginning of 2020, infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had rapidly evolved into an emergent worldwide pandemic, an outbreak whose unprecedented consequences highlighted many existing flaws within public healthcare systems across the world. While co...
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| مؤلفون آخرون: | , , , , , |
| التنسيق: | article |
| منشور في: |
2021
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.ijid.2021.02.071 https://www.sciencedirect.com/science/article/pii/S1201971221001569 http://hdl.handle.net/10576/17970 |
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| _version_ | 1857415087445245952 |
|---|---|
| author | Farhan, Cyprian |
| author2 | Sohail, Muhammad Umar Abdelhafez, Ibrahim Salman, Salma Attique, Zakria Kamareddine, Layla Al-Asmakh, Maha |
| author2_role | author author author author author author |
| author_facet | Farhan, Cyprian Sohail, Muhammad Umar Abdelhafez, Ibrahim Salman, Salma Attique, Zakria Kamareddine, Layla Al-Asmakh, Maha |
| author_role | author |
| dc.creator.none.fl_str_mv | Farhan, Cyprian Sohail, Muhammad Umar Abdelhafez, Ibrahim Salman, Salma Attique, Zakria Kamareddine, Layla Al-Asmakh, Maha |
| dc.date.none.fl_str_mv | 2021-03-25T06:35:51Z 2021-04-30 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.ijid.2021.02.071 Cyprian F, Sohail MU, Abdelhafez I, Salman S, Attique Z, Kamareddine L, Al-Asmakh M. SARS-CoV-2-Immune-Microbiome Interaction: Lessons from Respiratory Viral Infections. Int J Infect Dis. 2021 Feb 18;105:540–50. doi: 10.1016/j.ijid.2021.02.071. 12019712 https://www.sciencedirect.com/science/article/pii/S1201971221001569 http://hdl.handle.net/10576/17970 540-550 105 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | SARS-CoV-2 COVID-19 Respiratory tract microbiome Gut microbiome Immunity |
| dc.title.none.fl_str_mv | SARS-CoV-2 and immune-microbiome interactions: Lessons from respiratory viral infections |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | By the beginning of 2020, infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had rapidly evolved into an emergent worldwide pandemic, an outbreak whose unprecedented consequences highlighted many existing flaws within public healthcare systems across the world. While coronavirus disease 2019 (COVID-19) is bestowed with a broad spectrum of clinical manifestations, involving the vital organs, the respiratory system transpires as the main route of entry for SARS-CoV-2, with the lungs being its primary target. Of those infected, up to 20% require hospitalization on account of severity, while the majority of patients are either asymptomatic or exhibit mild symptoms. Exacerbation in the disease severity and complications of COVID-19 infection have been associated with multiple comorbidities, including hypertension, diabetes mellitus, cardiovascular disorders, cancer, and chronic lung disease. Interestingly, a recent body of evidence indicated the pulmonary and gut microbiomes as potential modulators for altering the course of COVID-19, potentially via the microbiome-immune system axis. While the relative concordance between microbes and immunity has yet to be fully elucidated with regards to COVID-19, we present an overview of our current understanding of COVID-19-microbiome-immune cross talk and discuss the potential contributions of microbiome-related immunity to SARS-CoV-2 pathogenesis and COVID-19 disease progression. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_98afe97dc73e217f2f04363c8e3f9d28 |
| identifier_str_mv | Cyprian F, Sohail MU, Abdelhafez I, Salman S, Attique Z, Kamareddine L, Al-Asmakh M. SARS-CoV-2-Immune-Microbiome Interaction: Lessons from Respiratory Viral Infections. Int J Infect Dis. 2021 Feb 18;105:540–50. doi: 10.1016/j.ijid.2021.02.071. 12019712 540-550 105 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/17970 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| spelling | SARS-CoV-2 and immune-microbiome interactions: Lessons from respiratory viral infectionsFarhan, CyprianSohail, Muhammad UmarAbdelhafez, IbrahimSalman, SalmaAttique, ZakriaKamareddine, LaylaAl-Asmakh, MahaSARS-CoV-2COVID-19Respiratory tract microbiomeGut microbiomeImmunityBy the beginning of 2020, infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had rapidly evolved into an emergent worldwide pandemic, an outbreak whose unprecedented consequences highlighted many existing flaws within public healthcare systems across the world. While coronavirus disease 2019 (COVID-19) is bestowed with a broad spectrum of clinical manifestations, involving the vital organs, the respiratory system transpires as the main route of entry for SARS-CoV-2, with the lungs being its primary target. Of those infected, up to 20% require hospitalization on account of severity, while the majority of patients are either asymptomatic or exhibit mild symptoms. Exacerbation in the disease severity and complications of COVID-19 infection have been associated with multiple comorbidities, including hypertension, diabetes mellitus, cardiovascular disorders, cancer, and chronic lung disease. Interestingly, a recent body of evidence indicated the pulmonary and gut microbiomes as potential modulators for altering the course of COVID-19, potentially via the microbiome-immune system axis. While the relative concordance between microbes and immunity has yet to be fully elucidated with regards to COVID-19, we present an overview of our current understanding of COVID-19-microbiome-immune cross talk and discuss the potential contributions of microbiome-related immunity to SARS-CoV-2 pathogenesis and COVID-19 disease progression.Elsevier2021-03-25T06:35:51Z2021-04-30Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.ijid.2021.02.071Cyprian F, Sohail MU, Abdelhafez I, Salman S, Attique Z, Kamareddine L, Al-Asmakh M. SARS-CoV-2-Immune-Microbiome Interaction: Lessons from Respiratory Viral Infections. Int J Infect Dis. 2021 Feb 18;105:540–50. doi: 10.1016/j.ijid.2021.02.071.12019712https://www.sciencedirect.com/science/article/pii/S1201971221001569http://hdl.handle.net/10576/17970540-550105enhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/179702024-07-23T11:23:31Z |
| spellingShingle | SARS-CoV-2 and immune-microbiome interactions: Lessons from respiratory viral infections Farhan, Cyprian SARS-CoV-2 COVID-19 Respiratory tract microbiome Gut microbiome Immunity |
| status_str | publishedVersion |
| title | SARS-CoV-2 and immune-microbiome interactions: Lessons from respiratory viral infections |
| title_full | SARS-CoV-2 and immune-microbiome interactions: Lessons from respiratory viral infections |
| title_fullStr | SARS-CoV-2 and immune-microbiome interactions: Lessons from respiratory viral infections |
| title_full_unstemmed | SARS-CoV-2 and immune-microbiome interactions: Lessons from respiratory viral infections |
| title_short | SARS-CoV-2 and immune-microbiome interactions: Lessons from respiratory viral infections |
| title_sort | SARS-CoV-2 and immune-microbiome interactions: Lessons from respiratory viral infections |
| topic | SARS-CoV-2 COVID-19 Respiratory tract microbiome Gut microbiome Immunity |
| url | http://dx.doi.org/10.1016/j.ijid.2021.02.071 https://www.sciencedirect.com/science/article/pii/S1201971221001569 http://hdl.handle.net/10576/17970 |