Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice
Chronic use of synthetic cannabinoids (SCs) has been associated with cognitive and behavioural deficits and an increased risk of neuropsychiatric disorders. The underlying molecular and cellular mechanisms of the neurotoxic effects of long-term use of SCs have not been well investigated in the liter...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , , , , , |
| التنسيق: | article |
| منشور في: |
2024
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.neuro.2024.05.009 https://www.sciencedirect.com/science/article/pii/S0161813X24000548 http://hdl.handle.net/10576/59323 |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1857415085165641728 |
|---|---|
| author | Ayman, Alzu'bi |
| author2 | Abu-El-Rub, Ejlal Almahasneh, Fatimah Tahat, Lena Athamneh, Rabaa Y. Khasawneh, Ramada Alzoubi, Hiba Ghorab, Doaa S. Almazari, Rawan Zoubi, Mazhar Salim Al Al-Zoubi, Raed M. |
| author2_role | author author author author author author author author author author |
| author_facet | Ayman, Alzu'bi Abu-El-Rub, Ejlal Almahasneh, Fatimah Tahat, Lena Athamneh, Rabaa Y. Khasawneh, Ramada Alzoubi, Hiba Ghorab, Doaa S. Almazari, Rawan Zoubi, Mazhar Salim Al Al-Zoubi, Raed M. |
| author_role | author |
| dc.creator.none.fl_str_mv | Ayman, Alzu'bi Abu-El-Rub, Ejlal Almahasneh, Fatimah Tahat, Lena Athamneh, Rabaa Y. Khasawneh, Ramada Alzoubi, Hiba Ghorab, Doaa S. Almazari, Rawan Zoubi, Mazhar Salim Al Al-Zoubi, Raed M. |
| dc.date.none.fl_str_mv | 2024-09-26T07:36:11Z 2024-05-31 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.neuro.2024.05.009 Alzu'bi, A., Abu-El-Rub, E., Almahasneh, F., Tahat, L., Athamneh, R. Y., Khasawneh, R., ... & Al-Zoubi, R. M. (2024). Delineating the Molecular Mechanisms of Hippocampal Neurotoxicity Induced by Chronic Administration of Synthetic Cannabinoid AB-FUBINACA in Mice. Neurotoxicology. 0161-813X https://www.sciencedirect.com/science/article/pii/S0161813X24000548 http://hdl.handle.net/10576/59323 103 1872-9711 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Synthetic cannabinoids AB-FUBINACA Neurotoxicity Recognition memory Psychosis Oxidative stress |
| dc.title.none.fl_str_mv | Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Chronic use of synthetic cannabinoids (SCs) has been associated with cognitive and behavioural deficits and an increased risk of neuropsychiatric disorders. The underlying molecular and cellular mechanisms of the neurotoxic effects of long-term use of SCs have not been well investigated in the literature. Herein, we evaluated the in vivo effects of chronic administration of AB-FUBINACA on the hippocampus in mice. Our results revealed that the administration of AB-FUBINACA induced a significant impairment in recognition memory associated with histopathological changes in the hippocampus. These findings were found to be correlated with increased level of oxidative stress, neuroinflammation, and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (BDNF), which plays an essential role in modulating synaptic plasticity integral for promoting learning and memory in the hippocampus. Additionally, we showed that AB-FUBINACA significantly decreased the expression of NR1, an important functional subunit of glutamate/NMDA receptors and closely implicated in the development of toxic psychosis. These findings shed light on the long-term neurotoxic effects of SCs on hippocampus and the underlying mechanisms of these effects. This study provided new targets for possible medical interventions to improve the treatment guidelines for SCs addiction. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_a26b565923592b8f0c9ccb3eb98051be |
| identifier_str_mv | Alzu'bi, A., Abu-El-Rub, E., Almahasneh, F., Tahat, L., Athamneh, R. Y., Khasawneh, R., ... & Al-Zoubi, R. M. (2024). Delineating the Molecular Mechanisms of Hippocampal Neurotoxicity Induced by Chronic Administration of Synthetic Cannabinoid AB-FUBINACA in Mice. Neurotoxicology. 0161-813X 103 1872-9711 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/59323 |
| publishDate | 2024 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in miceAyman, Alzu'biAbu-El-Rub, EjlalAlmahasneh, FatimahTahat, LenaAthamneh, Rabaa Y.Khasawneh, RamadaAlzoubi, HibaGhorab, Doaa S.Almazari, RawanZoubi, Mazhar Salim AlAl-Zoubi, Raed M.Synthetic cannabinoidsAB-FUBINACANeurotoxicityRecognition memoryPsychosisOxidative stressChronic use of synthetic cannabinoids (SCs) has been associated with cognitive and behavioural deficits and an increased risk of neuropsychiatric disorders. The underlying molecular and cellular mechanisms of the neurotoxic effects of long-term use of SCs have not been well investigated in the literature. Herein, we evaluated the in vivo effects of chronic administration of AB-FUBINACA on the hippocampus in mice. Our results revealed that the administration of AB-FUBINACA induced a significant impairment in recognition memory associated with histopathological changes in the hippocampus. These findings were found to be correlated with increased level of oxidative stress, neuroinflammation, and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (BDNF), which plays an essential role in modulating synaptic plasticity integral for promoting learning and memory in the hippocampus. Additionally, we showed that AB-FUBINACA significantly decreased the expression of NR1, an important functional subunit of glutamate/NMDA receptors and closely implicated in the development of toxic psychosis. These findings shed light on the long-term neurotoxic effects of SCs on hippocampus and the underlying mechanisms of these effects. This study provided new targets for possible medical interventions to improve the treatment guidelines for SCs addiction.This study was supported by a grant from the Deanship of Scientific Research, Yarmouk University, Jordan (Grant # 29/2021). The publication of this article is funded by Qatar National Library.Elsevier2024-09-26T07:36:11Z2024-05-31Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.neuro.2024.05.009Alzu'bi, A., Abu-El-Rub, E., Almahasneh, F., Tahat, L., Athamneh, R. Y., Khasawneh, R., ... & Al-Zoubi, R. M. (2024). Delineating the Molecular Mechanisms of Hippocampal Neurotoxicity Induced by Chronic Administration of Synthetic Cannabinoid AB-FUBINACA in Mice. Neurotoxicology.0161-813Xhttps://www.sciencedirect.com/science/article/pii/S0161813X24000548http://hdl.handle.net/10576/593231031872-9711enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/593232024-09-26T19:05:39Z |
| spellingShingle | Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice Ayman, Alzu'bi Synthetic cannabinoids AB-FUBINACA Neurotoxicity Recognition memory Psychosis Oxidative stress |
| status_str | publishedVersion |
| title | Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice |
| title_full | Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice |
| title_fullStr | Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice |
| title_full_unstemmed | Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice |
| title_short | Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice |
| title_sort | Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice |
| topic | Synthetic cannabinoids AB-FUBINACA Neurotoxicity Recognition memory Psychosis Oxidative stress |
| url | http://dx.doi.org/10.1016/j.neuro.2024.05.009 https://www.sciencedirect.com/science/article/pii/S0161813X24000548 http://hdl.handle.net/10576/59323 |