Toxicity assessment of di(2-ethylhexyl) phthalate using zebrafish embryos: Cardiotoxic potential
Plasticizers are considered as newly emerged contaminants. They are added to plastics to increase their flexibility and softness. Phthalate plasticizers including the Di-2-ethylhexyl phthalates (DEHP) are toxic and induce adverse effects on the different organization levels of the environment. In th...
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| مؤلفون آخرون: | , , , |
| التنسيق: | article |
| منشور في: |
2024
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.cbpc.2024.109956 https://www.sciencedirect.com/science/article/pii/S1532045624001248 http://hdl.handle.net/10576/55992 |
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| _version_ | 1857415084410667008 |
|---|---|
| author | Azza, Naïja |
| author2 | Horie, Yoshifumi Boughattas, Sonia Ismail, Sara Al-Mansouri, Nafja |
| author2_role | author author author author |
| author_facet | Azza, Naïja Horie, Yoshifumi Boughattas, Sonia Ismail, Sara Al-Mansouri, Nafja |
| author_role | author |
| dc.creator.none.fl_str_mv | Azza, Naïja Horie, Yoshifumi Boughattas, Sonia Ismail, Sara Al-Mansouri, Nafja |
| dc.date.none.fl_str_mv | 2024-06-11T04:16:53Z 2024-09-30 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.cbpc.2024.109956 15320456 https://www.sciencedirect.com/science/article/pii/S1532045624001248 http://hdl.handle.net/10576/55992 283 1878-1659 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | DEHP Cardiotoxicity Zebrafish embryos Heart function Gene expression |
| dc.title.none.fl_str_mv | Toxicity assessment of di(2-ethylhexyl) phthalate using zebrafish embryos: Cardiotoxic potential |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Plasticizers are considered as newly emerged contaminants. They are added to plastics to increase their flexibility and softness. Phthalate plasticizers including the Di-2-ethylhexyl phthalates (DEHP) are toxic and induce adverse effects on the different organization levels of the environment. In the current study, we investigated the potential toxicity of DEHP using Zebrafish as a biological model. Five ascending concentrations of DEHP were tested in embryos throughout 96 hpf: 0.0086, 0.086, 0.86, 8.6, and 86 mg/L. Embryotoxicity assessments revealed limited lethal effects on DEHP-exposed embryos, yet notable anticipation of the hatching process was observed at 48 hpf. Although DEHP showed negligible influence on the length and pericardial area of exposed embryos, it led to multiple bodily deformities. Gene expression analyses of key cardiogenic and inflammatory genes evidenced alterations in tbx20, bcl2, and il1b expression in Zebrafish embryos at 96 h post-fertilization. Results from the cardiac function analysis displayed that DEHP significantly affected the arterial pulse and linear velocity within the Posterior Cardinal Vein (PCV) of exposed fish. These findings strongly advance that even at low concentrations, DEHP can be considered as potential toxic agent, capable of inducing cardiotoxic effects. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_aa33cb1a9822e77b06b08e4a9877ba21 |
| identifier_str_mv | 15320456 283 1878-1659 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/55992 |
| publishDate | 2024 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Toxicity assessment of di(2-ethylhexyl) phthalate using zebrafish embryos: Cardiotoxic potentialAzza, NaïjaHorie, YoshifumiBoughattas, SoniaIsmail, SaraAl-Mansouri, NafjaDEHPCardiotoxicityZebrafish embryosHeart functionGene expressionPlasticizers are considered as newly emerged contaminants. They are added to plastics to increase their flexibility and softness. Phthalate plasticizers including the Di-2-ethylhexyl phthalates (DEHP) are toxic and induce adverse effects on the different organization levels of the environment. In the current study, we investigated the potential toxicity of DEHP using Zebrafish as a biological model. Five ascending concentrations of DEHP were tested in embryos throughout 96 hpf: 0.0086, 0.086, 0.86, 8.6, and 86 mg/L. Embryotoxicity assessments revealed limited lethal effects on DEHP-exposed embryos, yet notable anticipation of the hatching process was observed at 48 hpf. Although DEHP showed negligible influence on the length and pericardial area of exposed embryos, it led to multiple bodily deformities. Gene expression analyses of key cardiogenic and inflammatory genes evidenced alterations in tbx20, bcl2, and il1b expression in Zebrafish embryos at 96 h post-fertilization. Results from the cardiac function analysis displayed that DEHP significantly affected the arterial pulse and linear velocity within the Posterior Cardinal Vein (PCV) of exposed fish. These findings strongly advance that even at low concentrations, DEHP can be considered as potential toxic agent, capable of inducing cardiotoxic effects.The authors acknowledge the support and resources provided by Qatar University, particularly the Grant Office for their financial support. The Qatar National Library (QNL) (QATAR) provides the open-access fundings for the present work.Elsevier2024-06-11T04:16:53Z2024-09-30Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.cbpc.2024.10995615320456https://www.sciencedirect.com/science/article/pii/S1532045624001248http://hdl.handle.net/10576/559922831878-1659enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/559922024-07-23T10:58:47Z |
| spellingShingle | Toxicity assessment of di(2-ethylhexyl) phthalate using zebrafish embryos: Cardiotoxic potential Azza, Naïja DEHP Cardiotoxicity Zebrafish embryos Heart function Gene expression |
| status_str | publishedVersion |
| title | Toxicity assessment of di(2-ethylhexyl) phthalate using zebrafish embryos: Cardiotoxic potential |
| title_full | Toxicity assessment of di(2-ethylhexyl) phthalate using zebrafish embryos: Cardiotoxic potential |
| title_fullStr | Toxicity assessment of di(2-ethylhexyl) phthalate using zebrafish embryos: Cardiotoxic potential |
| title_full_unstemmed | Toxicity assessment of di(2-ethylhexyl) phthalate using zebrafish embryos: Cardiotoxic potential |
| title_short | Toxicity assessment of di(2-ethylhexyl) phthalate using zebrafish embryos: Cardiotoxic potential |
| title_sort | Toxicity assessment of di(2-ethylhexyl) phthalate using zebrafish embryos: Cardiotoxic potential |
| topic | DEHP Cardiotoxicity Zebrafish embryos Heart function Gene expression |
| url | http://dx.doi.org/10.1016/j.cbpc.2024.109956 https://www.sciencedirect.com/science/article/pii/S1532045624001248 http://hdl.handle.net/10576/55992 |