Role of HMGB1 and its associated signaling pathways in human malignancies
The High-Mobility Group Box-1 (HMGB1), a non-histone chromatin-associated protein, plays a crucial role in cancer growth and response to therapy as it retains a pivotal role in promoting both cell death and survival. HMGB1 has been reported to regulate several signaling pathways engaged in inflammat...
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| مؤلفون آخرون: | , , , , , , , |
| التنسيق: | article |
| منشور في: |
2023
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.cellsig.2023.110904 https://www.sciencedirect.com/science/article/pii/S0898656823003194 http://hdl.handle.net/10576/51325 |
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| _version_ | 1857415086751088640 |
|---|---|
| author | Sourour, Idoudi |
| author2 | Bedhiafi, Takwa Pedersen, Shona Elahtem, Mohamed Alremawi, Izzaldin Akhtar, Sabah Dermime, Said Merhi, Maysaloun Uddin, Shahab |
| author2_role | author author author author author author author author |
| author_facet | Sourour, Idoudi Bedhiafi, Takwa Pedersen, Shona Elahtem, Mohamed Alremawi, Izzaldin Akhtar, Sabah Dermime, Said Merhi, Maysaloun Uddin, Shahab |
| author_role | author |
| dc.creator.none.fl_str_mv | Sourour, Idoudi Bedhiafi, Takwa Pedersen, Shona Elahtem, Mohamed Alremawi, Izzaldin Akhtar, Sabah Dermime, Said Merhi, Maysaloun Uddin, Shahab |
| dc.date.none.fl_str_mv | 2023-09-25 2024-01-29T10:52:38Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.cellsig.2023.110904 Idoudi, S., Bedhiafi, T., Pedersen, S., Elahtem, M., Alremawi, I., Akhtar, S., ... & Uddin, S. (2023). Role of HMGB1 and its associated signaling pathways in human malignancies. Cellular Signalling, 110904. 0898-6568 https://www.sciencedirect.com/science/article/pii/S0898656823003194 http://hdl.handle.net/10576/51325 112 1873-3913 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | HMGB1 Signaling pathways cancer therapy Immune checkpoint blockade Clinical applications |
| dc.title.none.fl_str_mv | Role of HMGB1 and its associated signaling pathways in human malignancies |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The High-Mobility Group Box-1 (HMGB1), a non-histone chromatin-associated protein, plays a crucial role in cancer growth and response to therapy as it retains a pivotal role in promoting both cell death and survival. HMGB1 has been reported to regulate several signaling pathways engaged in inflammation, genome stability, immune function, cell proliferation, cell autophagy, metabolism, and apoptosis. However, the association between HMGB1 and cancer is complex and its mechanism in tumorigenesis needs to be further elucidated. This review aims to understand the role of HMGB1 in human malignancies and discuss the signaling pathways linked to this process to provide a comprehensive understanding on the association of HMGB1 with carcinogenesis. Further, we will review the role of HMGB1 as a target/biomarker for cancer therapy, the therapeutic strategies used to target this protein, and its potential role in preventing or treating cancers. In light of the recent growing evidence linking HMGB1 to cancer progression, we think that it may be suggested as a novel and emergent therapeutic target for cancer therapy. Hence, HMGB1 warrants paramount investigation to comprehensively map its role in tumorigenesis. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_ac43e4374b44baf861a927a8500d7eeb |
| identifier_str_mv | Idoudi, S., Bedhiafi, T., Pedersen, S., Elahtem, M., Alremawi, I., Akhtar, S., ... & Uddin, S. (2023). Role of HMGB1 and its associated signaling pathways in human malignancies. Cellular Signalling, 110904. 0898-6568 112 1873-3913 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/51325 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Role of HMGB1 and its associated signaling pathways in human malignanciesSourour, IdoudiBedhiafi, TakwaPedersen, ShonaElahtem, MohamedAlremawi, IzzaldinAkhtar, SabahDermime, SaidMerhi, MaysalounUddin, ShahabHMGB1Signaling pathwayscancer therapyImmune checkpoint blockadeClinical applicationsThe High-Mobility Group Box-1 (HMGB1), a non-histone chromatin-associated protein, plays a crucial role in cancer growth and response to therapy as it retains a pivotal role in promoting both cell death and survival. HMGB1 has been reported to regulate several signaling pathways engaged in inflammation, genome stability, immune function, cell proliferation, cell autophagy, metabolism, and apoptosis. However, the association between HMGB1 and cancer is complex and its mechanism in tumorigenesis needs to be further elucidated. This review aims to understand the role of HMGB1 in human malignancies and discuss the signaling pathways linked to this process to provide a comprehensive understanding on the association of HMGB1 with carcinogenesis. Further, we will review the role of HMGB1 as a target/biomarker for cancer therapy, the therapeutic strategies used to target this protein, and its potential role in preventing or treating cancers. In light of the recent growing evidence linking HMGB1 to cancer progression, we think that it may be suggested as a novel and emergent therapeutic target for cancer therapy. Hence, HMGB1 warrants paramount investigation to comprehensively map its role in tumorigenesis.The Open Access funding is provided by Qatar National Library, Doha, Qatar.Elsevier2024-01-29T10:52:38Z2023-09-25Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.cellsig.2023.110904Idoudi, S., Bedhiafi, T., Pedersen, S., Elahtem, M., Alremawi, I., Akhtar, S., ... & Uddin, S. (2023). Role of HMGB1 and its associated signaling pathways in human malignancies. Cellular Signalling, 110904.0898-6568https://www.sciencedirect.com/science/article/pii/S0898656823003194http://hdl.handle.net/10576/513251121873-3913enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/513252024-10-06T06:05:53Z |
| spellingShingle | Role of HMGB1 and its associated signaling pathways in human malignancies Sourour, Idoudi HMGB1 Signaling pathways cancer therapy Immune checkpoint blockade Clinical applications |
| status_str | publishedVersion |
| title | Role of HMGB1 and its associated signaling pathways in human malignancies |
| title_full | Role of HMGB1 and its associated signaling pathways in human malignancies |
| title_fullStr | Role of HMGB1 and its associated signaling pathways in human malignancies |
| title_full_unstemmed | Role of HMGB1 and its associated signaling pathways in human malignancies |
| title_short | Role of HMGB1 and its associated signaling pathways in human malignancies |
| title_sort | Role of HMGB1 and its associated signaling pathways in human malignancies |
| topic | HMGB1 Signaling pathways cancer therapy Immune checkpoint blockade Clinical applications |
| url | http://dx.doi.org/10.1016/j.cellsig.2023.110904 https://www.sciencedirect.com/science/article/pii/S0898656823003194 http://hdl.handle.net/10576/51325 |