The role of soluble CD40L in autoimmune diseases
CD40−CD40L is essential for immune system modulation because it coordinates both adaptive and inflammatory responses.Systemic lupus erythematosus, multiple sclerosis, inflammatory bowel disease, thrombocytopenic purpura, and rheumatoid arthritis are among the autoimmune illnesses in which it is espe...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2025
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.jtauto.2025.100288 https://www.sciencedirect.com/science/article/pii/S2589909025000231 http://hdl.handle.net/10576/65521 |
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| _version_ | 1857415083686100992 |
|---|---|
| author | Meryem, Mabrouk |
| author2 | Wahnou, Hicham Merhi, Yahye Abou-Saleh, Haissam Guessous, Fadila Zaid, Younes |
| author2_role | author author author author author |
| author_facet | Meryem, Mabrouk Wahnou, Hicham Merhi, Yahye Abou-Saleh, Haissam Guessous, Fadila Zaid, Younes |
| author_role | author |
| dc.creator.none.fl_str_mv | Meryem, Mabrouk Wahnou, Hicham Merhi, Yahye Abou-Saleh, Haissam Guessous, Fadila Zaid, Younes |
| dc.date.none.fl_str_mv | 2025-06-13T09:22:25Z 2025-04-19 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.jtauto.2025.100288 Mabrouk, M., Wahnou, H., Merhi, Y., Abou-Saleh, H., Guessous, F., & Zaid, Y. (2025). The role of soluble CD40L in autoimmune diseases. Journal of Translational Autoimmunity, 100288. https://www.sciencedirect.com/science/article/pii/S2589909025000231 http://hdl.handle.net/10576/65521 10 2589-9090 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | CD40L CD40 T lymphocytes Platelets Autoimmune disease |
| dc.title.none.fl_str_mv | The role of soluble CD40L in autoimmune diseases |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | CD40−CD40L is essential for immune system modulation because it coordinates both adaptive and inflammatory responses.Systemic lupus erythematosus, multiple sclerosis, inflammatory bowel disease, thrombocytopenic purpura, and rheumatoid arthritis are among the autoimmune illnesses in which it is especially prominent. Thus, the CD40−CD40L axis is a significant therapeutic target, despite the fact that its inhibition was first constrained by thromboembolic adverse effects.New therapeutic approaches, such as nanotechnological methods and new-generation monoclonal antibodies, have been developed as a result of recent research with the goal of enhancing therapy efficacy and safety. This study opens up new avenues for the treatment of autoimmune illnesses by examining the pathophysiological consequences of CD40−CD40L and reviewing new treatments that target this pathway. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_b660f22fbd9f0716c896e4e2a582c356 |
| identifier_str_mv | Mabrouk, M., Wahnou, H., Merhi, Y., Abou-Saleh, H., Guessous, F., & Zaid, Y. (2025). The role of soluble CD40L in autoimmune diseases. Journal of Translational Autoimmunity, 100288. 10 2589-9090 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/65521 |
| publishDate | 2025 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | The role of soluble CD40L in autoimmune diseasesMeryem, MabroukWahnou, HichamMerhi, YahyeAbou-Saleh, HaissamGuessous, FadilaZaid, YounesCD40LCD40T lymphocytesPlateletsAutoimmune diseaseCD40−CD40L is essential for immune system modulation because it coordinates both adaptive and inflammatory responses.Systemic lupus erythematosus, multiple sclerosis, inflammatory bowel disease, thrombocytopenic purpura, and rheumatoid arthritis are among the autoimmune illnesses in which it is especially prominent. Thus, the CD40−CD40L axis is a significant therapeutic target, despite the fact that its inhibition was first constrained by thromboembolic adverse effects.New therapeutic approaches, such as nanotechnological methods and new-generation monoclonal antibodies, have been developed as a result of recent research with the goal of enhancing therapy efficacy and safety. This study opens up new avenues for the treatment of autoimmune illnesses by examining the pathophysiological consequences of CD40−CD40L and reviewing new treatments that target this pathway.This work was financially supported by the National Center for Scientific and Technical Research ( CNRST ) of Morocco.Elsevier2025-06-13T09:22:25Z2025-04-19Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.jtauto.2025.100288Mabrouk, M., Wahnou, H., Merhi, Y., Abou-Saleh, H., Guessous, F., & Zaid, Y. (2025). The role of soluble CD40L in autoimmune diseases. Journal of Translational Autoimmunity, 100288.https://www.sciencedirect.com/science/article/pii/S2589909025000231http://hdl.handle.net/10576/65521102589-9090enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/655212025-06-13T19:06:33Z |
| spellingShingle | The role of soluble CD40L in autoimmune diseases Meryem, Mabrouk CD40L CD40 T lymphocytes Platelets Autoimmune disease |
| status_str | publishedVersion |
| title | The role of soluble CD40L in autoimmune diseases |
| title_full | The role of soluble CD40L in autoimmune diseases |
| title_fullStr | The role of soluble CD40L in autoimmune diseases |
| title_full_unstemmed | The role of soluble CD40L in autoimmune diseases |
| title_short | The role of soluble CD40L in autoimmune diseases |
| title_sort | The role of soluble CD40L in autoimmune diseases |
| topic | CD40L CD40 T lymphocytes Platelets Autoimmune disease |
| url | http://dx.doi.org/10.1016/j.jtauto.2025.100288 https://www.sciencedirect.com/science/article/pii/S2589909025000231 http://hdl.handle.net/10576/65521 |